Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling

Insulin prevents pulmonary vascular leakage by inhibiting transglutaminase 2 in diabetic mice

(2019) Hye-Yoon Jeon et al.   LIFE SCIENCES

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload

(2018) Arti V. Shinde et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

(2018) Zhuo Wang et al.   Cell Death & Disease

Role of Extracellular Matrix in the Pathogenesis of Pulmonary Arterial Hypertension

(2018) Thenappan Thenappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Insights into the Pulmonary Vascular complications of heart failure with Preserved Ejection Fraction

(2018) Yen‐Chun Lai et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pulmonary vascular collagen content, not cross-linking, contributes to right ventricular pulsatile afterload and overload in early pulmonary hypertension

(2017) Zhijie Wang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Role of tissue transglutaminase in age-associated ventricular stiffness

(2016) Young Jun Oh et al.   AMINO ACIDS

Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment

(2016) Michal Schäfer et al.   CURRENT HYPERTENSION REPORTS

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression

(2015) J. Lee et al.   CLINICAL CANCER RESEARCH

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

(2015) Kurt R. Stenmark et al.   JOURNAL OF APPLIED PHYSIOLOGY

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation

(2015) Sara Altuntas et al.   Oncotarget

Pulmonary Arterial Capacitance Is an Important Predictor of Mortality in Heart Failure With a Preserved Ejection Fraction

(2015) Nadine Al-Naamani et al.   JACC-Heart Failure

Cardiac Energy Metabolic Alterations in Pressure Overload–Induced Left and Right Heart Failure (2013 Grover Conference Series)

(2015) Sowndramalingam Sankaralingam et al.   Pulmonary Circulation

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation

(2014) Krishna C. Penumatsa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lysyl Oxidases Play a Causal Role in Vascular Remodeling in Clinical and Experimental Pulmonary Arterial Hypertension

(2014) A. H. Nave et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis

(2014) F Rossin et al.   CELL DEATH AND DIFFERENTIATION

The Metabolic Theory of Pulmonary Arterial Hypertension

(2014) Roxane Paulin et al.   CIRCULATION RESEARCH

Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice

(2014) Yali Zhang et al.   DIABETES

A Novel Mechanism by Which Tissue Transglutaminase Activates Signaling Events That Promote Cell Survival

(2014) Lindsey K. Boroughs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exercise, Vascular Stiffness, and Tissue Transglutaminase

(2014) Jochen Steppan et al.   Journal of the American Heart Association

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Metabolism and Bioenergetics in the Right Ventricle and Pulmonary Vasculature in Pulmonary Hypertension

(2014) Stephen L. Archer et al.   Pulmonary Circulation

Elevated Transglutaminase 2 Activity Is Associated with Hypoxia-Induced Experimental Pulmonary Hypertension in Mice

(2013) Thomas R. DiRaimondo et al.   ACS Chemical Biology

Transglutaminase 2-mediated serotonylation in pulmonary hypertension

(2013) K. C. Penumatsa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension

(2013) Silvia Rain et al.   CIRCULATION

Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity

(2013) Robert M. Weisbrod et al.   HYPERTENSION

Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways

(2013) Santosh Kumar et al.   INTERNATIONAL JOURNAL OF CANCER

HIF and pulmonary vascular responses to hypoxia

(2013) Larissa A. Shimoda et al.   JOURNAL OF APPLIED PHYSIOLOGY

Biventricular Remodeling in Murine Models of Right Ventricular Pressure Overload

(2013) Navin K. Kapur et al.   PLoS One

Serotonylated fibronectin is elevated in pulmonary hypertension

(2012) Lin Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Left Ventricular Failure Produces Profound Lung Remodeling and Pulmonary Hypertension in Mice

(2012) Yingjie Chen et al.   HYPERTENSION

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Glucose metabolism and cardiac hypertrophy

(2011) S. C. Kolwicz et al.   CARDIOVASCULAR RESEARCH

Pressure Load: The Main Factor for Altered Gene Expression in Right Ventricular Hypertrophy in Chronic Hypoxic Rats

(2011) Jonas D. Baandrup et al.   PLoS One

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

(2010) Tsubasa Isoe et al.   KIDNEY INTERNATIONAL

Human pyruvate kinase M2: A multifunctional protein

(2010) Vibhor Gupta et al.   PROTEIN SCIENCE

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY