Basic Science of Pulmonary Arterial Hypertension for Clinicians

Addition of Sildenafil to Long-Term Intravenous Epoprostenol Therapy in Patients with Pulmonary Arterial Hypertension

(2013) Gérald Simonneau   ANNALS OF INTERNAL MEDICINE

Spotlight on Sapropterin in Primary Hyperphenylalaninemia†

(2009) Mark Sanford et al.   BIODRUGS

Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension

(2009) Joachim Mittendorf et al.   ChemMedChem

Association of the Metabolic Syndrome With Pulmonary Venous Hypertension

(2009) Ivan M. Robbins et al.   CHEST

A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

(2009) Ying Yu et al.   CIRCULATION

Circulating Endothelial Cells

(2009) David M. Smadja et al.   CIRCULATION

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension

(2009) Lu Long et al.   CIRCULATION

Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway

(2009) Matthias Brock et al.   CIRCULATION RESEARCH

A Dosing/Cross-Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension

(2009) M Gomberg-Maitland et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells

(2009) Yinglin Liu et al.   FASEB JOURNAL

Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22α-targeted overexpression of the serotonin transporter

(2009) Christophe Guignabert et al.   FASEB JOURNAL

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

(2009) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Updated Clinical Classification of Pulmonary Hypertension

(2009) Gérald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Circulating Angiogenic Precursors in Idiopathic Pulmonary Arterial Hypertension

(2008) Kewal Asosingh et al.   AMERICAN JOURNAL OF PATHOLOGY

Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline

(2008) Matthew Thomas et al.   AMERICAN JOURNAL OF PATHOLOGY

Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

(2008) Reshma S. Baliga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Connective Tissue Disease–associated Pulmonary Arterial Hypertension in the Modern Treatment Era

(2008) Robin Condliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

(2008) K M Mair et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pulmonary Vascular Disease in the Developing World

(2008) Ghazwan Butrous et al.   CIRCULATION

Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice

(2008) Yvonne Dempsie et al.   CIRCULATION

Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension

(2008) Gerhard-Paul Diller et al.   CIRCULATION

Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension

(2008) Kwon-Ho Hong et al.   CIRCULATION

Mutations in Bone Morphogenetic Protein Type II Receptor Cause Dysregulation of Id Gene Expression in Pulmonary Artery Smooth Muscle Cells

(2008) Jun Yang et al.   CIRCULATION RESEARCH

Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion

(2008) S. A. Hamidi et al.   EUROPEAN RESPIRATORY JOURNAL

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

(2008) R. T. Schermuly et al.   EUROPEAN RESPIRATORY JOURNAL

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

(2008) A. Sobolewski et al.   HUMAN MOLECULAR GENETICS

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

(2008) Georg Hansmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term Inhaled Nitric Oxide Plus Phosphodiesterase 5 Inhibitors for Severe Pulmonary Hypertension

(2008) Gregorio Miguel Pérez-Peñate et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling

(2008) P. Wohlfart et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: Open-label pilot study

(2008) Jun Hui Zhu et al.   PEDIATRIC TRANSPLANTATION

Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

(2008) Liliana Moreno-Vinasco et al.   PHYSIOLOGICAL GENOMICS

Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension

(2008) Zhu JunHui et al.   RESPIRATORY MEDICINE

Underlying aetiology of pulmonary hypertension in 191 patients: A single centre experience

(2008) Oren FRUCHTER et al.   RESPIROLOGY

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

(2007) Stephen L. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reactivation of γHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin

(2007) Edda Spiekerkoetter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effects of erythropoietin on advanced pulmonary vascular remodelling

(2007) M. E. van Albada et al.   EUROPEAN RESPIRATORY JOURNAL

Increased Regulatory and Decreased CD8+ Cytotoxic T Cells in the Blood of Patients with Idiopathic Pulmonary Arterial Hypertension

(2007) Silvia Ulrich et al.   RESPIRATION