BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice

Intrinsic Mechanisms Regulating Neuronal Migration in the Postnatal Brain

(2021) Cedric Bressan et al.   Frontiers in Cellular Neuroscience

Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice

(2021) Felix Locker et al.   MOLECULES

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression

(2020) Abiola Abdulrahman Ayanlaja et al.   Cell Communication and Signaling

JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons

(2020) Abigail K. Myers et al.   DEVELOPMENT

Impact of JNK and Its Substrates on Dendritic Spine Morphology

(2020) Emilia Komulainen et al.   Cells

Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress

(2020) Nelly Maritza Vega-Rivera et al.   NEUROSCIENCE

Repulsive Guidance Molecule A Suppresses Adult Neurogenesis

(2020) Toke Jost Isaksen et al.   Stem Cell Reports

Critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in BDNF, adult hippocampal neurogenesis, and anti-anxiety-like behaviors

(2020) Dong Sun et al.   BIOLOGICAL PSYCHIATRY

Mouse–human co-clinical trials demonstrate superior anti-tumour effects of buparlisib (BKM120) and cetuximab combination in squamous cell carcinoma of head and neck

(2020) Hye Ryun Kim et al.   BRITISH JOURNAL OF CANCER

Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation

(2020) Felipe Fredes et al.   CURRENT BIOLOGY

Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments

(2020) Kisha Greer et al.   Scientific Reports

Non-Cell-Autonomous Mechanisms in Radial Projection Neuron Migration in the Developing Cerebral Cortex

(2020) Andi H. Hansen et al.   Frontiers in Cell and Developmental Biology

Mossy Cells in the Dorsal and Ventral Dentate Gyrus Differ in their Patterns of Axonal Projections

(2020) Carolyn R. Houser et al.   JOURNAL OF NEUROSCIENCE

Enhanced neurogenesis is involved in neuroprotection provided by rottlerin against trimethyltin-induced delayed apoptotic neuronal damage

(2020) Yeonggwang Hwang et al.   LIFE SCIENCES

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2019) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial

(2019) Patrick Y. Wen et al.   JOURNAL OF CLINICAL ONCOLOGY

Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments

(2019) Maryam Moslehi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Benefits versus risk profile of buparlisib for the treatment of breast cancer

(2019) Anne Patsouris et al.   Expert Opinion On Drug Safety

Lateral dispersion is required for circuit integration of newly generated dentate granule cells

(2019) Jia Wang et al.   Nature Communications

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus

(2018) Philipp Abe et al.   GLIA

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory

(2018) Anh D. Bui et al.   SCIENCE

Buparlisib is a brain penetrable pan-PI3K inhibitor

(2018) Mark C. de Gooijer et al.   Scientific Reports

The Free Radical Scavenger N-Tert-Butyl-α-Phenylnitrone (PBN) Administered to Immature Rats During Status Epilepticus Alters Neurogenesis and Has Variable Effects, Both Beneficial and Detrimental, on Long-Term Outcomes

(2018) Hana Kubová et al.   Frontiers in Cellular Neuroscience

Long-Term Stress and Concomitant Marijuana Smoke Exposure Affect Physiology, Behavior and Adult Hippocampal Neurogenesis

(2018) Kitti Rusznák et al.   Frontiers in Pharmacology

PI3K: A master regulator of brain metastasis-promoting macrophages/microglia

(2018) Raquel Blazquez et al.   GLIA

Phase II trial of the PI3 kinase inhibitor buparlisib (BKM-120) with or without enzalutamide in men with metastatic castration resistant prostate cancer

(2017) Andrew J. Armstrong et al.   EUROPEAN JOURNAL OF CANCER

Mechanisms of neuronal migration in the adult brain

(2017) Naoko Kaneko et al.   JOURNAL OF NEUROCHEMISTRY

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

(2017) Kavita Shah et al.   MOLECULAR NEUROBIOLOGY

Abnormal Development of Dendrites in Adult-Born Rat Hippocampal Granule Cells Induced by Cyclophosphamide

(2017) Lin Wu et al.   Frontiers in Cellular Neuroscience

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility

(2017) Abiola A. Ayanlaja et al.   Frontiers in Molecular Neuroscience

Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy

(2017) Wennan Zhao et al.   Acta Pharmaceutica Sinica B

Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development

(2017) Yuka Mimura-Yamamoto et al.   Scientific Reports

PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo

(2016) H. Niessner et al.   CLINICAL CANCER RESEARCH

Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats

(2016) I. A. Netland et al.   JOURNAL OF NEURO-ONCOLOGY

Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice

(2016) E. Siopi et al.   JOURNAL OF NEUROSCIENCE

Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice

(2016) The-Vinh Tran et al.   MOLECULAR NEUROBIOLOGY

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

(2016) Jing Ni et al.   NATURE MEDICINE

Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior

(2016) Dalinda Isabel Sánchez-Vidaña et al.   NEUROSCIENCE

PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex

(2016) Yasuhiro Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma

(2016) Maria-Carmela Speranza et al.   Scientific Reports

Traumatic Brain Injury Causes Aberrant Migration of Adult-Born Neurons in the Hippocampus

(2016) Sara Ibrahim et al.   Scientific Reports

Depression: from psychopathology to pathophysiology

(2015) Catherine Belzung et al.   CURRENT OPINION IN NEUROBIOLOGY

Buparlisib in breast cancer

(2015) Bhawna Sirohi et al.   Future Oncology

Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease

(2015) Janina Deusser et al.   JOURNAL OF NEUROCHEMISTRY

Downregulation of Sphingosine 1-Phosphate Receptor 1 Promotes the Switch from Tangential to Radial Migration in the OB

(2015) Julieta Alfonso et al.   JOURNAL OF NEUROSCIENCE

N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change

(2015) Eun-Joo Shin et al.   MOLECULAR NEUROBIOLOGY

An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development

(2015) Seung Tae Baek et al.   NATURE MEDICINE

Resolving the neural circuits of anxiety

(2015) Gwendolyn G Calhoon et al.   NATURE NEUROSCIENCE

Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

(2015) Alexis S Hill et al.   NEUROPSYCHOPHARMACOLOGY

Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain

(2015) Gerald J. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence

(2015) Sabrina F. Lisboa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation

(2015) Erin Y. Fenton et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline

(2015) Kyung-Ok Cho et al.   Nature Communications

Increased doublecortin (DCX) expression and incidence of DCX-immunoreactive multipolar cells in the subventricular zone-olfactory bulb system of suicides

(2015) Marissa E. Maheu et al.   Frontiers in Neuroanatomy

Functional dissociation of adult-born neurons along the dorsoventral axis of the dentate gyrus

(2014) Melody V. Wu et al.   HIPPOCAMPUS

Stand Up to Cancer Phase Ib Study of Pan-Phosphoinositide-3-Kinase Inhibitor Buparlisib With Letrozole in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer

(2014) Ingrid A. Mayer et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemotactic Responses of Neural Stem Cells to SDF-1α Correlate Closely with Their Differentiation Status

(2014) Yebing Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cyclin-Dependent Kinase 5 in the Ventral Tegmental Area Regulates Depression-Related Behaviors

(2014) P. Zhong et al.   JOURNAL OF NEUROSCIENCE

Neuronal morphometry directly from bitmap images

(2014) Tiago A Ferreira et al.   NATURE METHODS

ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis

(2014) Yingbo He et al.   NATURE NEUROSCIENCE

CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus

(2013) Clara Schultheiß et al.   HIPPOCAMPUS

Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis

(2013) Arnaud Tanti et al.   HIPPOCAMPUS

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus

(2013) April L. Lussier et al.   NEUROPHARMACOLOGY

Juvenile stress enhances anxiety and alters corticosteroid receptor expression in adulthood

(2013) Nichola M. Brydges et al.   Brain and Behavior

Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows

(2012) Tursun Alkam et al.   BEHAVIOURAL BRAIN RESEARCH

Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations

(2012) S. M. Brachmann et al.   MOLECULAR CANCER THERAPEUTICS

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

(2011) Johanna C. Bendell et al.   JOURNAL OF CLINICAL ONCOLOGY

Abnormal Neuronal Migration Changes the Fate of Developing Neurons in the Postnatal Olfactory Bulb

(2011) R. Belvindrah et al.   JOURNAL OF NEUROSCIENCE

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate

(2011) Nina Westerlund et al.   NATURE NEUROSCIENCE

JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration

(2010) Junghee Jin et al.   Developmental Neurobiology

The role of Rho GTPase proteins in CNS neuronal migration

(2010) Eve-Ellen Govek et al.   Developmental Neurobiology

Novel Embryonic Neuronal Migration and Proliferation Defects in Dcx Mutant Mice Are Exacerbated by Lis1 Reduction

(2010) T. Pramparo et al.   JOURNAL OF NEUROSCIENCE

Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients

(2010) Paul J. Lucassen et al.   NEUROPHARMACOLOGY

Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats

(2010) S. Brummelte et al.   NEUROSCIENCE

Upregulation of CXCR4 favoring neural-like cells migration via AKT activation

(2010) Shiyong Li et al.   NEUROSCIENCE RESEARCH

The Function of Notch1 Signaling Was Increased in Parallel with Neurogenesis in Rat Hippocampus after Chronic Fluoxetine Administration

(2009) Yuxiu Sui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Adult hippocampal neurogenesis is involved in anxiety-related behaviors

(2009) J-M Revest et al.   MOLECULAR PSYCHIATRY

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Antidepressants increase neural progenitor cells in the human hippocampus

(2009) Maura Boldrini et al.   NEUROPSYCHOPHARMACOLOGY

Cell migration in the normal and pathological postnatal mammalian brain

(2009) Myriam Cayre et al.   PROGRESS IN NEUROBIOLOGY

Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

(2008) J.-W. Wang et al.   JOURNAL OF NEUROSCIENCE

Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus

(2008) Sebastian Jessberger et al.   PLOS BIOLOGY