Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

Regulatory peptides and systems biology: A new era of translational and reverse‐translational neuroendocrinology

(2020) Lee E. Eiden et al.   JOURNAL OF NEUROENDOCRINOLOGY

Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood–Brain Barrier is Partially Mediated Through the HIF-1 Pathway

(2019) Shyanne Page et al.   NEUROMOLECULAR MEDICINE

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice

(2019) Srinidhi Jayaraman et al.   JOURNAL OF NEUROCHEMISTRY

NK1-r Antagonist Treatment Comparable to Decompressive Craniectomy in Reducing Intracranial Pressure Following Stroke

(2019) Annabel J. Sorby-Adams et al.   Frontiers in Neuroscience

Brain Delivery of a Potent Opioid Receptor Agonist, Biphalin during Ischemic Stroke: Role of Organic Anion Transporting Polypeptide (OATP)

(2019) Thamer H Albekairi et al.   Pharmaceutics

Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders

(2019) Vardan T. Karamyan   MEDICAL HYPOTHESES

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Hyaluronan impairs the barrier integrity of brain microvascular endothelial cells through a CD44-dependent pathway

(2018) Abraham J Al-Ahmad et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms

(2018) Amaly Nokkari et al.   PROGRESS IN NEUROBIOLOGY

Neurolysin: From Initial Detection to Latest Advances

(2018) Frédéric Checler et al.   NEUROCHEMICAL RESEARCH

The Role of Neurogenic Inflammation in Blood-Brain Barrier Disruption and Development of Cerebral Oedema Following Acute Central Nervous System (CNS) Injury

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isogenic blood-brain barrier models based on patient-derived stem cells display inter-individual differences in cell maturation and functionality

(2017) Ronak Patel et al.   JOURNAL OF NEUROCHEMISTRY

PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats

(2017) Teng-Fei Xue et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cells

(2017) Arti B. Patel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats

(2017) Hongfei Sang et al.   Translational Stroke Research

Preparation and preliminary characterization of recombinant neurolysin for in vivo studies

(2016) Naomi J. Wangler et al.   JOURNAL OF BIOTECHNOLOGY

Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke

(2016) Jill Roberts et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

VEGF Production by Ly6C+high Monocytes Contributes to Ventilator-Induced Lung Injury

(2016) Chung-Sheng Shi et al.   PLoS One

Ketamine alleviates bradykinin-induced disruption of the mouse cerebrovascular endothelial cell-constructed tight junction barrier via a calcium-mediated redistribution of occludin polymerization

(2016) Jui-Tai Chen et al.   TOXICOLOGY

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Analysis of Spatial and Temporal Protein Expression in the Cerebral Cortex after Ischemia-Reperfusion Injury

(2014) Yuan-Hao Chen et al.   Journal of Clinical Neurology

Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells

(2014) Aude Jacob et al.   JOURNAL OF NEUROCHEMISTRY

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

(2014) Ethan S. Lippmann et al.   Scientific Reports

Bradykinin promotes vascular endothelial growth factor expression and increases angiogenesis in human prostate cancer cells

(2013) Hsin-Shan Yu et al.   BIOCHEMICAL PHARMACOLOGY

The proinflammatory peptide substance P promotes blood-brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions

(2013) Pedro L. Rodriguez et al.   INTERNATIONAL JOURNAL OF CANCER

The Wnt/Planar Cell Polarity Signaling Pathway Contributes to the Integrity of Tight Junctions in Brain Endothelial Cells

(2013) Cédric Artus et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain

(2013) Mamoon Rashid et al.   JOURNAL OF NEUROCHEMISTRY

Bradykinin in Blood and Cerebrospinal Fluid after Acute Cerebral Lesions: Correlations with Cerebral Edema and Intracranial Pressure

(2013) Mathias Kunz et al.   JOURNAL OF NEUROTRAUMA

Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells

(2012) M. Vasiadi et al.   BRITISH JOURNAL OF DERMATOLOGY

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

(2012) Eduard Urich et al.   PLoS One

Neurotensin and CRH Interactions Augment Human Mast Cell Activation

(2012) Konstantinos–Dionysios Alysandratos et al.   PLoS One

Ischemic stroke and traumatic brain injury: The role of the kallikrein–kinin system

(2012) Christiane Albert-Weißenberger et al.   PROGRESS IN NEUROBIOLOGY

A substance P antagonist improves outcome when administered 4h after onset of ischaemic stroke

(2011) Renée J. Turner et al.   BRAIN RESEARCH

Identification of Membrane-bound Variant of Metalloendopeptidase Neurolysin (EC 3.4.24.16) as the Non-angiotensin Type 1 (Non-AT1), Non-AT2Angiotensin Binding Site

(2011) Naomi J. Wangler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells

(2011) Shahrzad Asadi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Acute Effects of a Selective Cannabinoid-2 Receptor Agonist on Neuroinflammation in a Model of Traumatic Brain Injury

(2011) Melanie B. Elliott et al.   JOURNAL OF NEUROTRAUMA

Endopeptidases 24.16 and 24.15 Are Responsible for the Degradation of Somatostatin, Neurotensin, and Other Neuropeptides by Cultivated Rat Cortical Astrocytes

(2010) Rolf Mentlein et al.   JOURNAL OF NEUROCHEMISTRY

Association of the Novel Non-AT1, Non-AT2 Angiotensin Binding Site with Neuronal Cell Death

(2010) M. Rashid et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

(2010) T. C. Theoharides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123

(2009) Leon M. Tai et al.   BRAIN RESEARCH

The Role of Bradykinin B1 and B2 Receptors for Secondary Brain Damage after Traumatic Brain Injury in Mice

(2009) Raimund Trabold et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Substance P is Associated with the Development of Brain Edema and Functional Deficits after Traumatic Brain Injury

(2009) James J Donkin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells

(2008) Sandrine Dauchy et al.   BIOCHEMICAL PHARMACOLOGY

The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

(2008) Birk Poller et al.   JOURNAL OF NEUROCHEMISTRY