Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs

Title
Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro–In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs
Authors
Keywords
hepatobiliary disposition, hepatic transport, efflux pumps, hepatic clearance, preclinical pharmacokinetics
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 106, Issue 9, Pages 2795-2804
Publisher
Elsevier BV
Online
2017-04-27
DOI
10.1016/j.xphs.2017.04.043

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