Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists

Published 2009 View Full Article

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Title
Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists
Authors
Keywords
-
Journal
DRUG METABOLISM AND DISPOSITION
Volume 37, Issue 9, Pages 1864-1870
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Online
2009-06-23
DOI
10.1124/dmd.109.027888

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