Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization

β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight

(2021) Xin Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioconvergent Substitution Reactions of Racemic Electrophiles by Organocatalysis

(2021) Jun Kikuchi et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Case Study in Catalyst Generality: Simultaneous, Highly-Enantioselective Brønsted- and Lewis-Acid Mechanisms in Hydrogen-Bond-Donor Catalyzed Oxetane Openings

(2021) Daniel A. Strassfeld et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Desymmetrization of 3-Substituted Oxetanes: An Efficient Access to Chiral 3,4-Dihydro-2H-1,4-benzoxazines

(2021) Viraj A. Bhosale et al.   ORGANIC LETTERS

Highly Enantioselective, Hydrogen-Bond-Donor Catalyzed Additions to Oxetanes

(2020) Daniel A. Strassfeld et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mild C–C Bond Formation via Lewis Acid Catalyzed Oxetane Ring Opening with Soft Carbon Nucleophiles

(2020) Hai Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes

(2020) Alexander Sandvoß et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Desymmetrization of Oxetanes for the Synthesis of Chiral Tetrahydrothiophenes and Tetrahydroselenophenes

(2019) Renwei Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mesembrine: The archetypal psycho-active Sceletium alkaloid

(2019) Felix Makolo et al.   PHYTOCHEMISTRY

Pd-Catalyzed Enantioselective [6+4] Cycloaddition of Vinyl Oxetanes with Azadienes to Access Ten-Membered Heterocycles

(2018) Ya-Nong Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Radical Cyclization for Construction of 5-Membered Ring Structures by Metalloradical C–H Alkylation

(2018) Yong Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

(2018) Xin Fang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

(2018) Jundong Li et al.   Organic Chemistry Frontiers

Enantioselective Oxetane Ring Opening with Chloride: Unusual Use of Wet Molecular Sieves for the Controlled Release of HCl

(2016) Wen Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

(2016) James A. Bull et al.   CHEMICAL REVIEWS

Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides

(2016) Pankaj Jain et al.   Nature Chemistry

Organocatalytic Enantioselective Synthesis of 1,4-Dioxanes and Other Oxa-Heterocycles by Oxetane Desymmetrization

(2015) Wen Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and Applications of Disulfonimides in Enantioselective Organocatalysis

(2015) Thomas James et al.   CHEMICAL REVIEWS

Stronger Brønsted Acids: Recent Progress

(2015) Takahiko Akiyama et al.   CHEMICAL REVIEWS

Recent Applications of Oxetanes in the Synthesis of Heterocyclic Compounds

(2015) Christian A. Malapit et al.   JOURNAL OF ORGANIC CHEMISTRY

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Rings in Drugs

(2014) Richard D. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic asymmetric nucleophilic openings of 3-substituted oxetanes

(2014) Zhaobin Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Complex Bioactive Alkaloid-Type Polycycles through Efficient Catalytic Asymmetric Multicomponent Aza-Diels-Alder Reaction of Indoles with Oxetane as Directing Group

(2013) Zhilong Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Intermolecular Desymmetrization of 3-Substituted Oxetanes

(2013) Zhaobin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Synthesis of Tetrahydroisoquinolines and Their Analogues Bearing a C4 Stereocenter: Formal Synthesis of (+)-(8S,13R)-Cyclocelabenzine

(2013) Zhilong Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioconvergent Cross-Couplings of Racemic Alkylmetal Reagents with Unactivated Secondary Alkyl Electrophiles: Catalytic Asymmetric Negishi α-Alkylations of N-Boc-pyrrolidine

(2013) Christopher J. Cordier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Thiourea-Catalyzed Intramolecular Cope-Type Hydroamination

(2013) Adam R. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in organocatalytic asymmetric synthesis of polysubstituted pyrrolidines

(2013) Man-Yi Han et al.   TETRAHEDRON LETTERS

Recent Advances in the Metal-Catalyzed Ring Expansions of Three- and Four-Membered Rings

(2013) Daniel J. Mack et al.   ACS Catalysis

Catalytic Ring Expansion of Vinyl Oxetanes: Asymmetric Synthesis of Dihydropyrans Using Chiral Counterion Catalysis

(2012) Boying Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Eight-Membered Lactones: Intermolecular [6+2] Cyclization of Amphoteric Molecules with Siloxy Alkynes

(2012) Wanxiang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct α-Functionalization of Saturated Cyclic Amines

(2012) Emily A. Mitchell et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dynamic One-Pot Three-Component Catalytic Asymmetric Transformation by Combination of Hydrogen-Bond-Donating and Amine Catalysts

(2011) Shuangzheng Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Pentanidium-Catalyzed Enantioselective Phase-Transfer Conjugate Addition Reactions

(2011) Ting Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Arylation ofN-Tosylalkylaldimines Catalyzed by Rhodium-Diene Complexes

(2011) Zhe Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Binaphthol-Derived Bisphosphoric Acids Serve as Efficient Organocatalysts for Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides to Electron-Deficient Olefins

(2011) Long He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Michael Addition of Aldehydes to Protected 2-Amino-1-Nitroethenes: The Practical Syntheses of Oseltamivir (Tamiflu) and Substituted 3-Aminopyrrolidines

(2010) Shaolin Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxetanes as Versatile Elements in Drug Discovery and Synthesis

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Applications oftert-Butanesulfinamide

(2010) MaryAnn T. Robak et al.   CHEMICAL REVIEWS

Enantioselective Intramolecular Openings of Oxetanes Catalyzed by (salen)Co(III) Complexes: Access to Enantioenriched Tetrahydrofurans

(2009) Rebecca N. Loy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Alkaloid Conessine and Analogues as Potent Histamine H3Receptor Antagonists

(2008) Chen Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides Catalyzed by Copper(I)/TF-BiphamPhos Complexes

(2008) Chun-Jiang Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY