β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight

Catalytic Asymmetric Reactions with N-Metallated Azomethine Ylides

(2020) Liang Wei et al.   ACCOUNTS OF CHEMICAL RESEARCH

Unusual KIE and dynamics effects in the Fe-catalyzed hetero-Diels-Alder reaction of unactivated aldehydes and dienes

(2020) Yuhong Yang et al.   Nature Communications

Chiral Trifluoromethylated Pyrrolidines via Cu–Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition

(2020) Xiang Cheng et al.   Asian Journal of Organic Chemistry

A Missing Piece of the Mechanism in Metal-Catalyzed Hydrogenation: Co(−I)/Co(0)/Co(+I) Catalytic Cycle for Co(−I)-Catalyzed Hydrogenation

(2019) Song-Bai Wu et al.   ORGANIC LETTERS

Copper(I)-Catalyzed Kinetic Resolution of exo-3-Oxodicyclopentadienes and endo-3-Oxodicyclopentadiene

(2019) Xin Chang et al.   ORGANIC LETTERS

Ag(I)-Fesulphos-Catalyzed Enantioselective Synthesis of 3-Silylproline Derivatives

(2019) Raghunath Chowdhury et al.   JOURNAL OF ORGANIC CHEMISTRY

P-Stereogenic Phosphines Directed Copper(I)-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions

(2019) Zhenjie Gan et al.   ORGANIC LETTERS

Copper-Catalyzed Regio- and Diastereoselective 1,3-Dipolar Cycloaddition Reactions of Glycine Imino Esters with 1-Propene-1,3-sultone

(2019) Shohei Furuya et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

1,3-Dipolar Cycloadditions of Stabilized Azomethine Ylides and Electrophilic Alkenes Mediated by a Recyclable TSIL·AgOAc Catalyst

(2019) David Lledó et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Switching Diastereoselectivity in Catalytic Enantioselective (3 + 2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos Derived Ligands

(2019) Guilherme S. Caleffi et al.   JOURNAL OF ORGANIC CHEMISTRY

Towards the online computer-aided design of catalytic pockets

(2019) Laura Falivene et al.   Nature Chemistry

Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale

(2019) John Hartung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Diastereodivergent Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides and β-Fluoroalkyl Vinylsulfones: Low Copper(II) Catalyst Loading and Theoretical Studies

(2019) Feng Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis

(2019) Marc J. C. Scanio et al.   ACS Medicinal Chemistry Letters

Enantioselective Synthesis of Fused Polycyclic Tropanes via Dearomative [3 + 2] Cycloaddition Reactions of 2-Nitrobenzofurans

(2019) Zhen Wang et al.   ORGANIC LETTERS

Catalytic asymmetric construction of spiropyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides

(2018) Xin Fang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Molecular Electron Density Theory Study of the Role of the Copper Metalation of Azomethine Ylides in [3 + 2] Cycloaddition Reactions

(2018) Luis R. Domingo et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction

(2018) Xiang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Well-Designed Phosphine–Urea Ligand for Highly Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Methacrylonitrile: A Combined Experimental and Theoretical Study

(2018) Yang Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction Mechanism of Cu(I)-Mediated Reductive CO2 Coupling for the Selective Formation of Oxalate: Cooperative CO2 Reduction To Give Mixed-Valence Cu2(CO2•–) and Nucleophilic-Like Attack

(2017) Jialing Lan et al.   INORGANIC CHEMISTRY

Nickel-catalyzed asymmetric hydrogenation of β-acylamino nitroolefins: an efficient approach to chiral amines

(2017) Wenchao Gao et al.   Chemical Science

Highly enantioselective catalytic synthesis of chiral pyridines

(2017) Ravindra P. Jumde et al.   Nature Communications

Catalytic Control in Cyclizations: From Computational Mechanistic Understanding to Selectivity Prediction

(2016) Qian Peng et al.   ACCOUNTS OF CHEMICAL RESEARCH

New Mechanistic Insights on the Selectivity of Transition-Metal-Catalyzed Organic Reactions: The Role of Computational Chemistry

(2016) Xinhao Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Alkenyl Arenes as Dipolarophiles in Catalytic Asymmetric 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides

(2016) Ana Pascual-Escudero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-controlled stereodivergent 1,3-dipolar cycloaddition of azomethine ylides with 3-methyl-4-nitro-5-styrylisoxazoles

(2016) Kang Liu et al.   CHEMICAL COMMUNICATIONS

Alternative Mechanistic Strategy for Enzyme Catalysis in a Ni-Dependent Lactate Racemase (LarA): Intermediate Destabilization by the Cofactor

(2016) Xiaoyong Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Practical Synthesis of MDM2 Antagonist RG7388. Part 1: A Cu(II)-Catalyzed Asymmetric [3 + 2] Cycloaddition

(2016) Lianhe Shu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Catalytic asymmetric addition of Grignard reagents to alkenyl-substituted aromatic N-heterocycles

(2016) R. P. Jumde et al.   SCIENCE

Chiral Monophosphorus Ligands for Asymmetric Catalytic Reactions

(2016) Wenzhen Fu et al.   ACS Catalysis

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

(2015) Rangappa S. Keri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Remote Substituent Effects on the Stereoselectivity and Organocatalytic Activity of Densely Substituted Unnatural Proline Esters in Aldol Reactions

(2015) María de Gracia Retamosa et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors

(2015) Maren Kuhnert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational Organic Chemistry: Bridging Theory and Experiment in Establishing the Mechanisms of Chemical Reactions

(2015) Gui-Juan Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Controlled Diastereoselective 1,3-Dipolar Cycloadditions of Azomethine Ylides with Methacrylonitrile

(2015) Mary C. Walton et al.   ORGANIC LETTERS

Mechanism of Ni-NHC Catalyzed Hydrogenolysis of Aryl Ethers: Roles of the Excess Base

(2015) Liping Xu et al.   ACS Catalysis

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

(2014) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

(2014) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

The benzazole scaffold: a SWAT to combat Alzheimer's disease

(2013) Sabrina Noël et al.   CHEMICAL SOCIETY REVIEWS

C═N-Containing Azaarenes as Activating Groups in Enantioselective Catalysis

(2013) Daniel Best et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

(2013) Yujun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

(2012) Masaki Setoguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cu(I)/TF-BiphamPhos Catalyzed Reactions of Alkylidene Bisphosphates and Alkylidene Malonates with Azomethine Ylides: Michael Addition versus 1,3-Dipolar Cycloaddition

(2012) Meiyan Wang et al.   ORGANOMETALLICS

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Aminosulfonamide-Catalyzed Direct Asymmetric Aldol Reaction in Brine

(2011) Tsuyoshi Miura et al.   SYNLETT

Amino Acid Catalysed Aldol Reactions in Cyclic Carbonate Solvents

(2011) Michael North et al.   SYNTHESIS-STUTTGART

Phosphoramidites: Privileged Ligands in Asymmetric Catalysis

(2010) Johannes F. Teichert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles

(2010) Dalip Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Direct Asymmetric Aldol Reaction with Recyclable Fluorous Organocatalyst

(2010) Tsuyoshi Miura et al.   ORGANIC LETTERS

Reversal of Enantioselectivity between the Copper(I)- and Silver(I)-Catalyzed 1,3-Dipolar Cycloaddition Reactions Using a Brucine-Derived Amino Alcohol Ligand

(2009) Hun Young Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

(2008) Thomas D. Penning et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Theory of 1,3-Dipolar Cycloadditions: Distortion/Interaction and Frontier Molecular Orbital Models

(2008) Daniel H. Ess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Indolizidine and quinolizidine alkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS