Blockade of corticotropin-releasing factor-1 receptors in the infralimbic cortex prevents stress-induced reinstatement of alcohol seeking in male Wistar rats: Evidence of interaction between CRF1 and orexin receptor signaling

Prefrontal Cortex Corticotropin-Releasing Factor Neurons Control Behavioral Style Selection under Challenging Situations

(2020) Peng Chen et al.   NEURON

VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks

(2019) Anthony T. Lee et al.   NEURON

Choice for Drug or Natural Reward Engages Largely Overlapping Neuronal Ensembles in the Infralimbic Prefrontal Cortex

(2018) Simone Pfarr et al.   JOURNAL OF NEUROSCIENCE

Orexin 2 receptor regulation of the hypothalamic–pituitary–adrenal (HPA) response to acute and repeated stress

(2017) Laura A. Grafe et al.   NEUROSCIENCE

The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking

(2017) Shaun Yon-Seng Khoo et al.   PLoS One

Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks

(2016) J. Antonio González et al.   Nature Communications

An Update on CRF Mechanisms Underlying Alcohol Use Disorders and Dependence

(2016) Isabel Marian Hartmann Quadros et al.   Frontiers in Endocrinology

Differential roles of medial prefrontal subregions in the regulation of drug seeking

(2015) David E. Moorman et al.   BRAIN RESEARCH

Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex

(2015) S. Pfarr et al.   JOURNAL OF NEUROSCIENCE

Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala

(2015) Kristen E. Pleil et al.   NEUROPHARMACOLOGY

Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction

(2015) David E. Moorman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats

(2015) Xinwen Dong et al.   Frontiers in Behavioral Neuroscience

Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement

(2014) Jason M. Uslaner et al.   BEHAVIOURAL BRAIN RESEARCH

Hypocretin (orexin) neuromodulation of stress and reward pathways

(2014) William J Giardino et al.   CURRENT OPINION IN NEUROBIOLOGY

Female Rats Display Enhanced Rewarding Effects of Ethanol That Are Hormone Dependent

(2013) Oscar V. Torres et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks

(2013) Xiaoyu Chen et al.   Brain Structure & Function

A Role for Hypocretin/Orexin Receptor-1 in Cue-Induced Reinstatement of Nicotine-Seeking Behavior

(2013) Ainhoa Plaza-Zabala et al.   NEUROPSYCHOPHARMACOLOGY

Activation of GABAergic pathway by hypocretin in the median raphe nucleus (MRN) mediates stress-induced theta rhythm in rats

(2012) Yi-Tse Hsiao et al.   BEHAVIOURAL BRAIN RESEARCH

The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat

(2012) Michel Alexander Steiner et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration

(2012) Subhashini Srinivasan et al.   PLoS One

Alcohol in excess: CRF1 receptors in the rat and mouse VTA and DRN

(2012) Lara S. Hwa et al.   PSYCHOPHARMACOLOGY

Hypocretin/Orexin Signaling in the Hypothalamic Paraventricular Nucleus is Essential for the Expression of Nicotine Withdrawal

(2011) Ainhoa Plaza-Zabala et al.   BIOLOGICAL PSYCHIATRY

Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats

(2011) Toshimichi Hata et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study

(2011) Anne E. Panhelainen et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429

(2011) Jesse R. Schank et al.   PSYCHOPHARMACOLOGY

A role for hypocretin/orexin in motivation

(2010) Jennifer L. Thompson et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of the mGlu2/3 Agonist LY379268 and the mGlu5 Antagonist MTEP on Ethanol Seeking and Reinforcement Are Differentially Altered in Rats with a History of Ethanol Dependence

(2010) Nimish Sidhpura et al.   BIOLOGICAL PSYCHIATRY

Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats

(2010) Andrea Cippitelli et al.   PSYCHOPHARMACOLOGY

Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking

(2009) Uri Shalev et al.   BRAIN RESEARCH

A Discrete GABAergic Relay Mediates Medial Prefrontal Cortical Inhibition of the Neuroendocrine Stress Response

(2009) J. J. Radley et al.   JOURNAL OF NEUROSCIENCE

Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats

(2009) R.F. Tavares et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

(2009) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Prefrontal cortex plasticity mechanisms in drug seeking and relapse

(2009) Michel C. Van den Oever et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry

(2009) Peter W. Kalivas   NEUROTOXICITY RESEARCH

A Role for Brain Stress Systems in Addiction

(2008) George F. Koob   NEURON

Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system

(2008) Antonello Bonci et al.   NEUROPHARMACOLOGY

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats

(2008) Jemma K. Richards et al.   PSYCHOPHARMACOLOGY