Article
Pharmacology & Pharmacy
Francisco J. Flores-Ramirez, Florence P. Varodayan, Reesha R. Patel, Jessica M. Illenberger, Francesca Di Ottavio, Marisa Roberto, Remi Martin-Fardon
Summary: Chronic alcohol use dysregulates stress responsivity, making individuals vulnerable to relapse. This study found that the OX1/2 receptor in the infralimbic cortex plays a significant role in stress-induced reinstatement of alcohol-seeking behavior. Using the OX1/2 antagonist TCS 1102 can prevent reinstatement in alcohol-dependent animals.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Francisco J. Flores-Ramirez, Jessica M. Illenberger, Glenn E. Pascasio, Alessandra Matzeu, Barbara J. Mason, Remi Martin-Fardon
Summary: Alcohol use disorder (AUD), a treatment-resistant medical condition, was studied using a dual orexin receptor antagonist, suvorexant, which was found to decrease alcohol intake and prevent stress-induced alcohol-seeking behavior in male rats with a history of alcohol dependence. Targeting the orexin system shows promise for the treatment of substance use disorders, including AUD.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jessica M. M. Illenberger, Francisco J. J. Flores-Ramirez, Alessandra Matzeu, Barbara J. J. Mason, Remi Martin-Fardon
Summary: This study showed that suvorexant can reduce self-administration and relapse of prescription opioids, especially in females.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Jessica M. Illenberger, Francisco J. Flores-Ramirez, Glenn Pascasio, Alessandra Matzeu, Remi Martin-Fardon
Summary: Chronic opioid use disrupts circadian rhythm and sleep, which can lead to increased opioid use and relapse. Dual orexin receptor antagonists (DORAs), developed for insomnia treatment, are found to alleviate withdrawal-associated sleep disturbances. This study aimed to investigate the effect of DORA-12, a newly developed DORA, on physiological activity disturbances during oxycodone abstinence and its potential role in preventing oxycodone-seeking behavior.
Article
Pharmacology & Pharmacy
Anthony Markham
Summary: Daridorexant, an orally administered dual orexin receptor antagonist, has been approved in the USA for the treatment of insomnia based on the results of pivotal phase III trials.
Article
Multidisciplinary Sciences
Bolanle Fatimat Olabiyi, Anne-Caroline Schmoele, Eva Carolina Beins, Andreas Zimmer
Summary: CB2 signaling plays a role in regulating microglial responses to inflammation. However, acute pharmacological inhibition of CB2 does not have the same effect on microglial activation as genetic deletion of CB2.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Erin E. Maher, Paula F. Overby, Amanda H. Bull, Joshua S. Beckmann, Jonna M. Leyrer-Jackson, Stephanie Koebele, Heather A. Bimonte-Nelson, Cassandra D. Gipson
Summary: This study found that women have more difficulty quitting smoking and currently available treatments are less effective for women. Fluctuations in ovarian hormones across the menstrual cycle can affect craving and smoking relapse propensity. Natural and synthetic estrogens play a critical role in mediating the neurobehavioral effects of nicotine.
Article
Medicine, Research & Experimental
Farzaneh Nazari-Serenjeh, Ronak Azizbeigi, Mina Rashvand, Somaye Mesgar, Haleh Amirteymori, Abbas Haghparast
Summary: Due to the relapsing properties of psychostimulants like methamphetamine, there is currently no established pharmacotherapy for methamphetamine addiction. The orexinergic system shows promise as a target for treating psychostimulant use disorders and relapse. However, no previous research has investigated the role of orexin receptors in the dentate gyrus region of the hippocampus in the extinction and reinstatement of methamphetamine-seeking behavior. This study implanted guide cannulae into the brains of rats and conducted conditioned place preference procedures. The results indicated distinct roles for the OX1 and OX2 receptors in the dentate gyrus region, suggesting that the orexinergic system in this region could be a potential therapeutic target for psychostimulant use disorders.
Article
Immunology
Solenne Vigne, Donovan Duc, Benjamin Peter, Jessica Rebeaud, Yannick Yersin, Florian Ruiz, Valentine Bressoud, Tinh-Hai Collet, Caroline Pot
Summary: This study investigated the effect of circulating cholesterol levels on multiple sclerosis (MS) using a mouse model. The results showed that blood cholesterol level does not have a direct role in neuro-inflammatory diseases, and the protective effects of statins in MS are not related to circulating cholesterol.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Maria E. Hammarlund, C. Joakim Ek, Sukaina Akar, Alma Karlsson, Bagmi Pattanaik, Filip Mjornstedt, Pernilla Svedin, Maryam Ardalan, Eridan Rocha-Ferreira, Carina Mallard, Maria E. Johansson
Summary: Inflammation plays an important role in the development of neonatal brain injury. Activation of alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR) has shown to decrease acute inflammatory responses in male pups, but does not affect overall injury outcome.
Article
Clinical Neurology
Marie-Laure Boof, Mike Ufer, Ingo Fietze, Jean-Louis Pepin, Anne-Sophie Guern, Vincent Lemoine, Jasper Dingemanse
Summary: The study found that daridorexant can be safely used in patients with mild to moderate obstructive sleep apnea, with similar effects on respiration and sleep as placebo, but with an increase in some respiratory events.
Review
Psychiatry
Habibolah Khazaie, Masoud Sadeghi, Sepideh Khazaie, Max Hirshkowitz, Amir Sharafkhaneh
Summary: The study conducted a systematic review and meta-analysis on the treatment of insomnia with suvorexant and lemborexant, showing that both drugs are effective and safe for patients with insomnia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Hiroshi Tsuneki, Masanori Sugiyama, Kiyofumi Sato, Hisakatsu Ito, Sanaka Nagai, Kanta Kon, Tsutomu Wada, Nao Kobayashi, Takuya Okada, Naoki Toyooka, Masashi Kawasaki, Toshihiro Ito, Ryota Otsubo, Daisuke Okuzaki, Teruhito Yasui, Toshiyasu Sasaoka
Summary: The drug lemborexant, used to treat insomnia, has been found to have a positive effect on sleep and glucose metabolism in individuals with type 2 diabetes. In experiments, lemborexant increased sleep duration and improved glucose tolerance in db/db mice. This improvement did not affect body weight or insulin secretion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yihui Dong, Nir Kampf, Yaelle Schilt, Wei Cao, Uri Raviv, Jacob Klein
Summary: Phosphatidylcholine (PC) lipid bilayers with high hydration can significantly reduce sliding friction on surfaces. This study found that dehydration does not greatly affect the friction, as the higher areal head-group density and rigidity enhancement of the lipid bilayers offset the removal of hydration water from the lipid head-groups. This highlights the robustness of lipid-based hydration lubrication in biological systems.
Article
Pharmacology & Pharmacy
Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Recent research indicates that BCP, through its action on CB2 receptors and other mechanisms, can effectively reduce METH reward and intake, as well as motivation to seek and take METH. Additionally, BCP also inhibits METH-enhanced electrical BSR, and blocks METH-primed and cue-induced reinstatement of drug-seeking behavior.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Yu Liu, Philip Jean-Richard-dit-Bressel, Joanna Oi-Yue Yau, Alexandra Willing, Asheeta A. Prasad, John M. Power, Simon Killcross, Colin W. G. Clifford, Gavan P. McNally
JOURNAL OF NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Yu Liu, Gavan P. McNally
Summary: Dopamine plays a crucial role in relapse to drug seeking, with different forms of relapse being driven by distinct dopamine mechanisms. Understanding the diverse dopamine pathways involved in relapse behaviors is essential for developing effective strategies to prevent relapse.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Behavioral Sciences
Constance Y. Peng, Philip Jean-Richard-dit-Bressel, Sophia Gilchrist, John M. Power, Gavan P. McNally
Summary: The study shows that optogenetic inhibition of VTA dopamine neurons leads to a response-specific, contingency-sensitive suppression of instrumental responding, similar to the effects of aversive events in instrumental preparations.
BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Shaun Yon-Seng Khoo, Alexandra Uhrig, Anne-Noel Samaha, Nadia Chaudhri
Summary: The study investigated the effects of dopamine D1-like and D2-like receptor antagonism on sign-tracking and goal-tracking conditioned responses, finding that D2 receptor activity is crucial for goal-tracking but not for sign-tracking. Additionally, psychomotor sensitization induced by amphetamine did not impact incentive salience attribution.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Philip Jean-Richard-dit-Bressel, Jenny Tran, Angelos Didachos, Gavan P. McNally
Summary: Punishment learning relies on aversion-coding of instrumental responses in the basolateral amygdala (BLA), with benzodiazepines mitigating punishment effects by reversing the aversion coding in BLA.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Caroline Garceau, Anne-Noel Samaha, Thomas Cordahi, Alice Servonnet, Shaun Yon-Seng Khoo
Summary: Reward-associated cues can trigger incentive motivation for reward via Pavlovian-to-instrumental transfer, with glutamate signaling in the basolateral amygdala playing a role in modulating cue-triggered increases in motivation. The study showed that metabotropic group II glutamate receptors in the BLA mediate cue-triggered potentiation of incentive motivation for reward, suppressing both instrumental pursuit of the reward and anticipatory approach behavior.
PSYCHOPHARMACOLOGY
(2021)
Article
Biology
Philip Jean-Richard-Dit-Bressel, Jessica C. Lee, Shi Xian Liew, Gabrielle Weidemann, Peter F. Lovibond, Gavan P. McNally
Summary: Research has shown that differences in sensitivity to punishment can impact decision-making abilities and psychopathologies. In humans, individuals who are sensitive and insensitive to punishment show similar preferences for rewards and aversion to punishments, but differ significantly in their ability to detect and learn how to control aversive outcomes.
Article
Neurosciences
Joanna Oi-Yue Yau, Chanchanok Chaichim, John M. Power, Gavan P. McNally
Summary: The study used transgenic PV-Cre rats to reveal that BLA PV neurons regulate fear learning about aversive events. The research also showed the sensitivity of BLA PV neurons to aversive prediction error and their selectivity for specific sensory features.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Philip Jean Richard Dit Bressel, Gavan P. McNally
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Joanna Oi-Yue Yau, Gavan P. McNally
Summary: This study investigated the role of dopamine neurons in safety learning in the rat ventral tegmental area (VTA). The findings suggest that shock omission during safety learning is selectively associated with calcium transients in dopamine neurons in the medial VTA, and the magnitude of these calcium transients accurately predicts the amount of safety that is learned.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Eun A. Choi, Medina Husic, E. Zayra Millan, Sophia Gilchrist, John M. Power, Philip Jean-Richard Dit Bressel, Gavan P. McNally
Summary: This study investigates the decision-making process of mice in the presence of danger and demonstrates how mice balance decision speed and safety. The researchers identify the involvement of the corticothalamic pathway in cognitive control during decision-making under conflict, showing that increased activity in the paraventricular thalamus leads to increased decision caution and longer decision times in the presence of danger.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Stephanie Murphy, Metika Collis Glynn, Tiarani N. Dixon, Harvey J. Grill, Gavan P. McNally, Zhi Yi Ong
Summary: The NTS A2 neurons play a significant role in controlling food intake, suppressing consumption without affecting food approach, anxiety-like behaviors, or locomotor activity. Their projections to the PVH, rather than the BNST, mediate this control.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gavan P. McNally, Philip Jean-Richard-dit-Bressel, E. Zayra Millan, Andrew J. Lawrence
Summary: The persistence of drug taking despite its adverse consequences has a significant impact on addiction. There are at least three pathways involved in persistent drug use: cognitive recognition of adverse consequences, motivational valuation of these consequences, and behavioral responses to adverse consequences. These pathways are dynamic and can lead to different trajectories of behavior change. Understanding and targeting these pathways are important for effective treatment.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Philip Jean-Richard-dit-Bressel, Jessica C. Lee, Shi Xian Liew, Gabrielle Weidemann, Peter F. Lovibond, Gavan P. McNally
Summary: Individuals differ in their sensitivity to the consequences of their actions. Three pathways, including motivational, behavioral, and cognitive pathways, contribute to this sensitivity. Punishment sensitivity is influenced by the individuals' beliefs about the causes of their actions. Incorrect causal beliefs can lead to maladaptive behaviors, especially when punishment is infrequent, causing resistance to updating behavior based on experience and information.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Information Science & Library Science
Shaun Yon-Seng Khoo
Summary: The Plan S Rights Retention Strategy requires authors to inform publishers that their manuscripts will be published under a CC BY license, potentially increasing administrative and legal burdens for authors and readers. The complexity of copyright law and CC licensing raises doubts about the legal validity of RRS licenses, creating legal risks. Publishers are already taking actions to protect their revenue streams, leaving authors to decide between publication fees and funding agreements.
INSIGHTS-THE UKSG JOURNAL
(2021)