The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward

(2011) Daniel M. Hutcheson et al.   BEHAVIOURAL PHARMACOLOGY

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

(2011) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Functional Magnetic Resonance Imaging Reveals Different Neural Substrates for the Effects of Orexin-1 and Orexin-2 Receptor Antagonists

(2011) Alessandro Gozzi et al.   PLoS One

Orexin/hypocretin plays a role in the response to physiological disequilibrium

(2011) Christopher M. Sinton   SLEEP MEDICINE REVIEWS

The orexin system: roles in sleep/wake regulation

(2010) Takeshi Sakurai et al.   Annals of the New York Academy of Sciences

Glucocorticoid Receptors in Dopaminoceptive Neurons, Key for Cocaine, Are Dispensable for Molecular and Behavioral Morphine Responses

(2010) Jacques Barik et al.   BIOLOGICAL PSYCHIATRY

Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin1 receptors

(2010) B Jupp et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin Receptor Antagonism, a New Sleep-Promoting Paradigm: An Ascending Single-Dose Study With Almorexant

(2010) P Hoever et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Differential Effects of the Dual Orexin Receptor Antagonist Almorexant and the GABAA-α1 Receptor Modulator Zolpidem, Alone or Combined with Ethanol, on Motor Performance in the Rat

(2010) Michel A Steiner et al.   NEUROPSYCHOPHARMACOLOGY

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA

(2010) Mark G. LeSage et al.   PSYCHOPHARMACOLOGY

Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine

(2010) M. M. J. Veeneman et al.   PSYCHOPHARMACOLOGY

Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement

(2010) James R. Shoblock et al.   PSYCHOPHARMACOLOGY

Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

(2010) Hendrik Dietrich et al.   PSYCHOPHARMACOLOGY

Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization

(2009) Ruth Sharf et al.   BRAIN RESEARCH

The brain hypocretins and their receptors: mediators of allostatic arousal

(2009) Matthew E Carter et al.   CURRENT OPINION IN PHARMACOLOGY

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking

(2009) Rachel J. Smith et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area

(2009) Jill Watson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

(2009) S. L. Borgland et al.   JOURNAL OF NEUROSCIENCE

Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat

(2009) C. Dugovic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization

(2009) Davide Quarta et al.   NEUROCHEMISTRY INTERNATIONAL

Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

(2009) Christopher J. Winrow et al.   NEUROPHARMACOLOGY

Orexin/hypocretin is necessary for context-driven cocaine-seeking

(2009) Rachel J. Smith et al.   NEUROPHARMACOLOGY

Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System

(2009) N. Tsujino et al.   PHARMACOLOGICAL REVIEWS

Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice

(2009) Erik R. Hill et al.   PLoS One

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

(2008) S. L. Borgland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY

Effects of cocaine place conditioning, chronic escalating-dose “binge” pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague–Dawley rats

(2008) Y. Zhou et al.   NEUROSCIENCE

Abuse and dependence liability of benzodiazepine-type drugs: GABAA receptor modulation and beyond

(2008) Stephanie C. Licata et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Insular hypocretin transmission regulates nicotine reward

(2008) J. A. Hollander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA