Mapping the human kidney using single-cell genomics

Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney

(2021) Isao Matsui et al.   Scientific Reports

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

(2021) Nicholas Borcherding et al.   Communications Biology

Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney

(2021) Amin Abedini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Single-Cell RNA-seq Identifies Minority Cell Types of Kidney Distal Nephron

(2021) Lihe Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phenotypic diversity and metabolic specialization of renal endothelial cells

(2021) Sébastien J. Dumas et al.   Nature Reviews Nephrology

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

(2021) Bing He et al.   Nature Communications

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

(2021) Yoshiharu Muto et al.   Nature Communications

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

(2021) Zhen Miao et al.   Nature Communications

Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

(2021) Vijay Saxena et al.   Nature Communications

A Partial Picture of the Single-Cell Transcriptomics of Human IgA Nephropathy

(2021) Rong Tang et al.   Frontiers in Immunology

Spatial transcriptional mapping of the human nephrogenic program

(2021) Nils O. Lindström et al.   DEVELOPMENTAL CELL

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

(2021) Xin Sheng et al.   NATURE GENETICS

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response

(2021) Yuping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Cell Sequencing and Kidney Organoids Generated from Pluripotent Stem Cells

(2020) Haojia Wu et al.   Clinical Journal of the American Society of Nephrology

Genetic and preimplantation diagnosis of cystic kidney disease with ventriculomegaly

(2020) Lei Zhang et al.   JOURNAL OF HUMAN GENETICS

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes

(2020) Junyi Hu et al.   MOLECULAR THERAPY

Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells

(2020) Anna Julie Peired et al.   Science Translational Medicine

A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells

(2020) Hiraku Tsujimoto et al.   Cell Reports

Association of Urine sCD163 With Proliferative Lupus Nephritis, Fibrinoid Necrosis, Cellular Crescents and Intrarenal M2 Macrophages

(2020) Ting Zhang et al.   Frontiers in Immunology

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

(2020) Jun-Jae Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-Cell RNA Sequencing Reveals mRNA Splice Isoform Switching during Kidney Development

(2020) Yishay Wineberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

(2020) Yuhei Kirita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated urine proteomics and renal single-cell genomics identify an IFN-γ response gradient in lupus nephritis

(2020) Andrea Fava et al.   JCI Insight

Histopathologic Correlates of Kidney Function: Insights From Nephrectomy Specimens

(2020) Ping Li et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

(2020) Bryan R. Conway et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human kidney organoids produce functional renin

(2020) Anusha S. Shankar et al.   KIDNEY INTERNATIONAL

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

(2020) Poonam Dhillon et al.   Cell Metabolism

Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients

(2020) Christian Hinze et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2

(2020) Robert R. Stickels et al.   NATURE BIOTECHNOLOGY

Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy

(2020) Ying Zheng et al.   Cell Reports

MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes

(2020) Hiroyuki Yamada et al.   KIDNEY INTERNATIONAL

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

(2019) Alexander N. Combes et al.   Genome Medicine

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development

(2019) Mazène Hochane et al.   PLOS BIOLOGY

Single-Cell RNA Profiling of Glomerular Cells Shows Dynamic Changes in Experimental Diabetic Kidney Disease

(2019) Jia Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Immune Infiltration in Renal Cell Carcinoma

(2019) Shichao Zhang et al.   CANCER SCIENCE

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

(2019) Evan Der et al.   NATURE IMMUNOLOGY

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

(2019) Jian Hui Low et al.   Cell Stem Cell

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes

(2019) Tracy Tran et al.   DEVELOPMENTAL CELL

Renal-Tubule Epithelial Cell Nomenclature for Single-Cell RNA-Sequencing Studies

(2019) Lihe Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys

(2019) Blue B. Lake et al.   Nature Communications

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

Publisher Correction: The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

The single-cell transcriptomic landscape of early human diabetic nephropathy

(2019) Parker C. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney

(2019) Andrew Ransick et al.   DEVELOPMENTAL CELL

Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

(2019) Ayshwarya Subramanian et al.   Nature Communications

Using single-cell technologies to map the human immune system — implications for nephrology

(2019) Benjamin J. Stewart et al.   Nature Reviews Nephrology

AJKD Atlas of Renal Pathology: Pierson Syndrome

(2018) Mark A. Lusco et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf

(2018) Bliss Magella et al.   DEVELOPMENTAL BIOLOGY

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis

(2018) Nils O. Lindström et al.   DEVELOPMENTAL CELL

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

(2018) Nikos Karaiskos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney

(2018) Rajasree Menon et al.   DEVELOPMENT

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

(2018) Matthew D. Young et al.   SCIENCE

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evaluation of variability in human kidney organoids

(2018) Belinda Phipson et al.   NATURE METHODS

Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes

(2017) Yuqiu Lu et al.   KIDNEY INTERNATIONAL

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease

(2017) Andreas Kompatscher et al.   KIDNEY INTERNATIONAL

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

(2017) Max Werth et al.   eLife

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

The origin of the mammalian kidney: implications for recreating the kidney in vitro

(2015) M. Takasato et al.   DEVELOPMENT

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

How much can the tubule regenerate and who does it? An open question

(2015) Duccio Lombardi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Single cell dissection of early kidney development: multilineage priming

(2014) E. W. Brunskill et al.   DEVELOPMENT

Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

(2014) Sébastien A Smallwood et al.   NATURE METHODS

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Aqp2-Expressing Cells Give Rise to Renal Intercalated Cells

(2013) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-cell Hi-C reveals cell-to-cell variability in chromosome structure

(2013) Takashi Nagano et al.   NATURE

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Deletion of hensin/DMBT1 blocks conversion of  - to  -intercalated cells and induces distal renal tubular acidosis

(2010) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review: Updates on novel therapies for metastatic renal cell carcinoma

(2010) Kevin D. Courtney et al.   Therapeutic Advances in Medical Oncology

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Developmental biology of the human kidney

(2007) Norman D. Rosenblum   Seminars in Fetal & Neonatal Medicine