Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus

Brain ventricles as windows into brain development and disease

(2022) Phan Q. Duy et al.   NEURON

Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience

(2021) Helen Rankin Willsey et al.   NEURON

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

(2021) Daniel Taliun et al.   NATURE

Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

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Intraventricular Cerebrospinal Fluid Turbulence in Pediatric Communicating Hydrocephalus

(2021) Phan Q Duy et al.   NEUROLOGY

PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targets

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Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

(2020) Emily E. Burke et al.   Nature Communications

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

(2020) John DeSisto et al.   DEVELOPMENTAL CELL

Electric field stimulates production of highly conductive microbial OmcZ nanowires

(2020) Sibel Ebru Yalcin et al.   Nature Chemical Biology

Mutations disrupting neuritogenesis genes confer risk for cerebral palsy

(2020) Sheng Chih Jin et al.   NATURE GENETICS

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus

(2020) Sheng Chih Jin et al.   NATURE MEDICINE

Exome Sequencing as a Potential Diagnostic Adjunct in Sporadic Congenital Hydrocephalus

(2020) William Sullivan et al.   JAMA Pediatrics

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

(2019) Dogukan Mizrak et al.   Cell Reports

Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus

(2019) Phan Q. Duy et al.   TRENDS IN MOLECULAR MEDICINE

The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

(2019) Thomas Welte et al.   GENES & DEVELOPMENT

Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus

(2019) Priya Date et al.   Scientific Reports

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms

(2019) Rebecca L. Walker et al.   CELL

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus

(2018) Charuta Gavankar Furey et al.   NEURON

Cotransporter-mediated water transport underlying cerebrospinal fluid formation

(2018) Annette B. Steffensen et al.   Nature Communications

Systematic Evaluation of Molecular Networks for Discovery of Disease Genes

(2018) Justin K. Huang et al.   Cell Systems

Characterization of the ventricular-subventricular stem cell niche during human brain development

(2018) Amanda M. Coletti et al.   DEVELOPMENT

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation

(2018) Daniel Duran et al.   NEURON

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Association of Severe Hydrocephalus With Congenital Zika Syndrome

(2018) Vanessa van der Linden et al.   JAMA Neurology

PAR-CLIP and streamlined small RNA cDNA library preparation protocol for the identification of RNA binding protein target sites

(2017) Daniel Benhalevy et al.   METHODS

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

(2017) Sheng Chih Jin et al.   NATURE GENETICS

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

(2017) Jason K Karimy et al.   NATURE MEDICINE

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

(2017) Tomasz J. Nowakowski et al.   SCIENCE

The Genetic Basis of Hydrocephalus

(2016) Maria Kousi et al.   Annual Review of Neuroscience

Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes

(2016) Sean Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

(2016) Marco Onorati et al.   Cell Reports

Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry

(2016) Elizabeth Peruski Canovic et al.   Jove-Journal of Visualized Experiments

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Ciliobrevins as tools for studying dynein motor function

(2015) Douglas H. Roossien et al.   Frontiers in Cellular Neuroscience

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71

(2015) Sibylle Mitschka et al.   Scientific Reports

Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies

(2015) C. Dong et al.   HUMAN MOLECULAR GENETICS

A Bayesian framework for de novo mutation calling in parents-offspring trios

(2014) Qiang Wei et al.   BIOINFORMATICS

Infantile hydrocephalus: A review of epidemiology, classification and causes

(2014) Hannah M. Tully et al.   European Journal of Medical Genetics

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Objective comparison of particle tracking methods

(2014) Nicolas Chenouard et al.   NATURE METHODS

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

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Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes

(2013) Kathleen A. Worringer et al.   Cell Stem Cell

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling

(2012) J. Chen et al.   GENES & DEVELOPMENT

The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure

(2011) Betsy R. Maller Schulman et al.   CELL CYCLE

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure

(2010) T. N. Phoenix et al.   GENES & DEVELOPMENT

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Age-Dependent Regional Mechanical Properties of the Rat Hippocampus and Cortex

(2009) Benjamin S. Elkin   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Evolution of the neocortex: a perspective from developmental biology

(2009) Pasko Rakic   NATURE REVIEWS NEUROSCIENCE