Journal
TRENDS IN MOLECULAR MEDICINE
Volume 25, Issue 6, Pages 467-469Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2019.03.004
Keywords
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Funding
- NIH Medical Scientist Training Program Training Grant [T32GM007205]
- National Institutes of Health
- Hydrocephalus Association
- Rudi Schulte Research Institute
- Simons Foundation
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Tripartite motif 71 (Trim71)/lineage defective 41 (lin-41) is the primary target of the ancient lethal 7 (let-7) miRNA that is essential for survival and development across animal phylogeny. Recent work identified Trim71 as a critical regulator of mammalian neural stem cell NSC) fate and a bona fide human disease gene in congenital hydrocephalus (CH). Studying TRIM71 as a paradigm of NSC involvement in CH is a remarkable opportunity to better understand the mechanisms that regulate the timing of brain development and the pathogenesis of the most common pediatric neurosurgical disorder.
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