Journal
TRENDS IN NEUROSCIENCES
Volume 44, Issue 12, Pages 961-976Publisher
CELL PRESS
DOI: 10.1016/j.tins.2021.08.007
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Funding
- National Institutes of Health [NRCDP K12 228168, 1RO1NS109358, R01 NS111029-01A1, R01MH116002]
- Hydrocephalus Association
- March of Dimes
- Simons Foundation
- Swebilius Foundation
- Rudi Schulte Research Institute
- Binational Science Foundation
- Kavli Foundation
- National Genetics Foundation
- Spector Fund
- National Institutes of Health Medical Scientist Training Program Training Grant [T32GM007205]
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [F31NS115519]
- Interdepartmental Neuroscience Program at Yale
- National Institutes of Health Training Program Grant in Genetics NIH [5T32GM007499]
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Research suggests that there is shared molecular pathophysiology between autism spectrum disorder (ASD) and congenital hydrocephalus (CH), with the PTEN-PI3K-mTOR pathway potentially serving as a common underlying mechanism for these two conditions. This provides diagnostic, prognostic, and therapeutic promise for individuals with ASD and CH.
The lack of effective treatments for autism spectrum disorder (ASD) and congenital hydrocephalus (CH) reflects the limited understanding of the biology underlying these common neurodevelopmental disorders. Although ASD and CH have been extensively studied as independent entities, recent human genomic and preclinical animal studies have uncovered shared molecular pathophysiology. Here, we review and discuss phenotypic, genomic, and molecular similarities between ASD and CH, and identify the PTEN-PI3K-mTOR (phosphatase and tensin homolog- phosphoinositide 3-kinase-mammalian target of rapamycin) pathway as a common underlying mechanism that holds diagnostic, prognostic, and therapeutic promise for individuals with ASD and CH.
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