Journal
NEURON
Volume 110, Issue 1, Pages 12-15Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2021.12.009
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Funding
- NIH [T32GM136651, F30HD106694, K99HL143036, ROOHL143036-02]
- Hydrocephalus Association Innovator Award
- NIDA [DA023999, R01NS111029-01A1, R01NS109358, K12228168]
- Rudi Schulte Research Institute
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Dilation of fluid-filled cerebral ventricles, known as ventriculomegaly, is a common feature of hydrocephalus and is often seen in autism and schizophrenia. Recent research indicates that studying the genomics of congenital hydrocephalus may provide valuable insights into neural stem cell regulation, human cerebrocortical development, and the pathogenesis of neuropsychiatric diseases.
Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.
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