Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

(2020) Chantell S Evans et al.   eLife

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

(2020) Sinsuk Han et al.   EMBO REPORTS

Somatic autophagy of axonal mitochondria in ischemic neurons

(2019) Yanrong Zheng et al.   JOURNAL OF CELL BIOLOGY

Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

(2019) Tamar Farfel-Becker et al.   Cell Reports

Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles

(2019) Xia Li et al.   Cell Reports

Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals

(2018) Eugene Jennifer Jin et al.   CURRENT BIOLOGY

Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons

(2018) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes

(2018) Chan Choo Yap et al.   JOURNAL OF CELL BIOLOGY

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

Quality science from quality measurement: The role of measurement type with respect to replication and effect size magnitude in psychological research

(2018) Diana E. Kornbrot et al.   PLoS One

Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo

(2018) Lee Ju-Hyun et al.   Autophagy

Presynaptic Biogenesis Requires Axonal Transport of Lysosome-Related Vesicles

(2018) Anela Vukoja et al.   NEURON

A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC Complex Results in Motor Deficits and Dystrophic Axonopathy in Mice

(2018) John N. Snouwaert et al.   Cell Reports

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Segregation in the Golgi complex precedes export of endolysosomal proteins in distinct transport carriers

(2017) Yu Chen et al.   JOURNAL OF CELL BIOLOGY

WDR91 is a Rab7 effector required for neuronal development

(2017) Kai Liu et al.   JOURNAL OF CELL BIOLOGY

A Ragulator–BORC interaction controls lysosome positioning in response to amino acid availability

(2017) Jing Pu et al.   JOURNAL OF CELL BIOLOGY

BORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon

(2017) Ginny G. Farías et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

(2017) Maria B. Bagh et al.   Nature Communications

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8

(2016) Debapriya Ghosh et al.   Nature Communications

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

(2015) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit

(2015) Maria De Luca et al.   JOURNAL OF CELL SCIENCE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in neuronal cells: general principles and physiological and pathological functions

(2014) Markus Damme et al.   ACTA NEUROPATHOLOGICA

Autophagy and Its Normal and Pathogenic States in the Brain

(2014) Ai Yamamoto et al.   Annual Review of Neuroscience

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

The signaling lipid PI(3,5)P2 stabilizes V1–Vo sector interactions and activates the V-ATPase

(2014) Sheena Claire Li et al.   MOLECULAR BIOLOGY OF THE CELL

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

(2014) Xue Xue et al.   NANO LETTERS

A Super-Ecliptic, pHluorin-mKate2, Tandem Fluorescent Protein-Tagged Human LC3 for the Monitoring of Mammalian Autophagy

(2014) Isei Tanida et al.   PLoS One

Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus

(2014) Erin K. Bomati et al.   Scientific Reports

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins

(2013) Maaike S. Pols et al.   Nature Communications

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Motor Coordination via a Tug-of-War Mechanism Drives Bidirectional Vesicle Transport

(2010) Adam G. Hendricks et al.   CURRENT BIOLOGY

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations

(2010) Hazel Urwin et al.   HUMAN MOLECULAR GENETICS

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease

(2008) Dun-Sheng Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Morphogenesis of post-Golgi transport carriers

(2008) Alberto Luini et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE