Self-generated gradients steer collective migration on viscoelastic collagen networks

Collective durotaxis along a self-generated stiffness gradient in vivo

(2021) Adam Shellard et al.   NATURE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown

(2020) Luke Tweedy et al.   SCIENCE

Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration

(2020) Greg M. Allen et al.   Cell Systems

Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

(2019) Amelia J Thompson et al.   eLife

Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy

(2019) Carlo Bevilacqua et al.   Biomedical Optics Express

Brillouin microscopy: an emerging tool for mechanobiology

(2019) Robert Prevedel et al.   NATURE METHODS

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

The Role of Network Architecture in Collagen Mechanics

(2018) Karin A. Jansen et al.   BIOPHYSICAL JOURNAL

Nondestructive assessment of collagen hydrogel cross-linking using time-resolved autofluorescence imaging

(2018) Benjamin E. Sherlock et al.   JOURNAL OF BIOMEDICAL OPTICS

Tumor Budding in Colorectal Carcinoma: Translating a Morphologic Score Into Clinically Meaningful Results

(2018) Soo-Jin Cho et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging

(2018) Raimund Schlüßler et al.   BIOPHYSICAL JOURNAL

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

(2018) Elias H. Barriga et al.   NATURE

Active wetting of epithelial tissues

(2018) Carlos Pérez-González et al.   Nature Physics

A new biomimetic assay reveals the temporal role of matrix stiffening in cancer cell invasion

(2018) Ralitza Staneva et al.   MOLECULAR BIOLOGY OF THE CELL

Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis

(2018) Adam Shellard et al.   SCIENCE

Tumor budding in colorectal cancer—ready for diagnostic practice?

(2016) Viktor H. Koelzer et al.   HUMAN PATHOLOGY

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels

(2016) Sungmin Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Tensile Forces Originating from Cancer Spheroids Facilitate Tumor Invasion

(2016) Katarzyna S. Kopanska et al.   PLoS One

The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks

(2015) Jiranuwat Sapudom et al.   BIOMATERIALS

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence

(2015) Paolo Maiuri et al.   CELL

Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion

(2015) Gema Malet-Engra et al.   CURRENT BIOLOGY

Stress controls the mechanics of collagen networks

(2015) Albert James Licup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

(2015) Stephanie I. Fraley et al.   Scientific Reports

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer

(2014) Jeremy S. Bredfeldt et al.   JOURNAL OF BIOMEDICAL OPTICS

A Three-Dimensional Computational Model of Collagen Network Mechanics

(2014) Byoungkoo Lee et al.   PLoS One

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Spontaneous autophoretic motion of isotropic particles

(2013) Sébastien Michelin et al.   PHYSICS OF FLUIDS

Rapid disorganization of mechanically interacting systems of mammary acini

(2013) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

(2013) Sara Geraldo et al.   Jove-Journal of Visualized Experiments

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Scaling of Traction Forces with the Size of Cohesive Cell Colonies

(2012) Aaron F. Mertz et al.   PHYSICAL REVIEW LETTERS

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor Budding as a Strong Prognostic Indicator in Invasive Ampullary Adenocarcinomas

(2010) Nobuyuki Ohike et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

(2010) Cristina Hidalgo-Carcedo et al.   NATURE CELL BIOLOGY

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Physical forces during collective cell migration

(2009) Xavier Trepat et al.   Nature Physics

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor Budding is a Strong and Reproducible Prognostic Marker in T3N0 Colorectal Cancer

(2008) Lai Mun Wang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY