Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

(2021) Yael Cohen-Sharir et al.   NATURE

Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

(2021) Ryan J. Quinton et al.   NATURE

A clinically applicable integrative molecular classification of meningiomas

(2021) Farshad Nassiri et al.   NATURE

Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results

(2021) Wenya Linda Bi et al.   NEURO-ONCOLOGY

Meningeal lymphatic vessels regulate brain tumor drainage and immunity

(2020) Xueting Hu et al.   CELL RESEARCH

CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas

(2020) Philipp Sievers et al.   ACTA NEUROPATHOLOGICA

The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies

(2020) Briana C Prager et al.   Cancer Discovery

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

(2020) Sarah Findakly et al.   Acta Neuropathologica Communications

Associations of Meningioma Molecular Subgroup and Tumor Recurrence

(2020) Mark W Youngblood et al.   NEURO-ONCOLOGY

A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection

(2020) William C Chen et al.   NEUROSURGERY

Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma

(2020) Stephen T. Magill et al.   Nature Communications

Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic

(2020) Erik A. Williams et al.   Acta Neuropathologica Communications

Chromothripsis drives the evolution of gene amplification in cancer

(2020) Ofer Shoshani et al.   NATURE

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters

(2019) Arnold J. Levine et al.   CANCER CELL

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

(2019) Nagarajan Paramasivam et al.   ACTA NEUROPATHOLOGICA

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management

(2019) Farshad Nassiri et al.   NEURO-ONCOLOGY

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

YAP1-fusions in pediatric NF2-wildtype meningioma

(2019) Philipp Sievers et al.   ACTA NEUROPATHOLOGICA

Analysis of CDKN2A gene alterations in recurrent and non-recurrent meningioma

(2019) Anne Guyot et al.   JOURNAL OF NEURO-ONCOLOGY

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

MNGI-01. A PHASE 0 TRIAL OF RIBOCICLIB IN AGGRESSIVE MENINGIOMA PATIENTS INCORPORATING A TUMOR PHARMACODYNAMIC- AND PHARMACOKINETIC-GUIDED EXPANSION COHORT

(2019) An-Chi Tien et al.   NEURO-ONCOLOGY

CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones

(2018) Sören Müller et al.   BIOINFORMATICS

Tumor purity quantification by clonal DNA methylation signatures

(2018) Matteo Benelli et al.   BIOINFORMATICS

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

(2018) Marlies Ballegeer et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

An enhanced CRISPR repressor for targeted mammalian gene regulation

(2018) Nan Cher Yeo et al.   NATURE METHODS

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma

(2018) Sabine Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

(2018) Maike Frye et al.   Nature Communications

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation

(2018) Harish N. Vasudevan et al.   Cell Reports

Lymphangiogenesis guidance by paracrine and pericellular factors

(2017) Kari Vaahtomeri et al.   GENES & DEVELOPMENT

Evaluation of GRCh38 and de novo haploid genome assemblies demonstrates the enduring quality of the reference assembly

(2017) Valerie A. Schneider et al.   GENOME RESEARCH

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

(2017) Felix Sahm et al.   LANCET ONCOLOGY

BAP1 mutations in high-grade meningioma: implications for patient care

(2017) Ganesh M Shankar et al.   NEURO-ONCOLOGY

Integrated genomic analyses of de novo pathways underlying atypical meningiomas

(2017) Akdes Serin Harmancı et al.   Nature Communications

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

(2017) Sameer Agnihotri et al.   Nature Communications

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

Genomic landscape of intracranial meningiomas

(2016) Wenya Linda Bi et al.   JOURNAL OF NEUROSURGERY

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

(2016) Victoria E Clark et al.   NATURE GENETICS

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin

(2015) Christine Chiasson-MacKenzie et al.   JOURNAL OF CELL BIOLOGY

Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review

(2015) Leland Rogers et al.   JOURNAL OF NEUROSURGERY

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry

(2013) Felix Sahm et al.   ACTA NEUROPATHOLOGICA

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

(2013) David E. Reuss et al.   ACTA NEUROPATHOLOGICA

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

(2013) Priscilla K Brastianos et al.   NATURE GENETICS

Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO

(2013) V. E. Clark et al.   SCIENCE

Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation

(2012) Shahani Noor et al.   Journal of Neuroinflammation

The p38 MAPK-MK2 Axis Regulates E2F1 and FOXM1 Expression after Epirubicin Treatment

(2012) N. de Olano et al.   MOLECULAR CANCER RESEARCH

Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

(2010) Wei Li et al.   CELL

Interaction between the extracellular matrix and lymphatics: Consequences for lymphangiogenesis and lymphatic function

(2010) Helge Wiig et al.   MATRIX BIOLOGY

The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid Inhibition

(2010) J. R. Flammer et al.   MOLECULAR AND CELLULAR BIOLOGY

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

Neurofibromatosis type 2 (NF2): A clinical and molecular review

(2009) D Gareth R Evans   Orphanet Journal of Rare Diseases