Article
Oncology
Zhenwang Zhang, Wu Liu, Xiajun Bao, Tian Sun, Jiawei Wang, Mengxi Li, Chao Liu
Summary: This study reveals the role of deubiquitinating enzyme USP39 in promoting breast cancer cell proliferation and tumor growth through deubiquitination and stabilization of FOXM1. Elevated USP39 expression reduces FOXM1 ubiquitination levels, enhancing its transcriptional activity and regulating the expression of downstream genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shuchao Dong, Jiayi Ling, Liuxia Song, Liping Zhao, Yinlei Wang, Tongmin Zhao
Summary: Drought has a significant impact on tomatoes, leading to tissue dehydration and decreased yield. The key genes involved in dehydration response and tolerance in tomatoes are still not well understood. Dehydration decreases the relative water content of tomato leaves and promotes the content of malondialdehyde and ion leakage. Dehydration also triggers oxidative stress and enhances the activity of antioxidant enzymes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jin-Kyoung Shim, Seung Hoon Lim, Ji Hye Jeong, Ran Joo Choi, Yoojung Oh, Junseong Park, Sunghee Choi, Junpyo Hong, Seo Jin Kim, Ju Hyung Moon, Eui Hyun Kim, Wan-Yee Teo, Bong Jin Park, Jong Hee Chang, Jae-Ha Ryu, Seok-Gu Kang
Summary: The lignan DFS inhibits the proliferation of GBM tumorspheres by suppressing FOXM1, suggesting its potential as a therapeutic agent for GBM.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Jonathan D. Mahoney, Sining Wang, Liam A. Iorio, Jill L. Wegrzyn, Matthew Dorris, Derek Martin, Bradley W. Bolling, Mark H. Brand, Huanzhong Wang
Summary: This study investigated the molecular mechanisms of polyphenol biosynthesis in Aronia fruit development using Illumina RNA-seq transcriptome analysis. The transcriptomic data revealed significant up-regulation of genes related to anthocyanin biosynthesis during fruit development. The findings provide valuable insights into the molecular mechanisms of fruit anthocyanin biosynthesis in Aronia and other species of the Rosaceae family.
Article
Cell Biology
Huitong Bu, Xianling Lan, Haojie Cheng, Chaozhu Pei, Min Ouyang, Yan Chen, Xiaoqin Huang, Li Yu, Yongjun Tan
Summary: Disrupting protein-protein interactions has emerged as a promising strategy for cancer drug development. Using a rational design approach, a peptide library was generated from the FOXM1 C-terminal sequence and a FOXM1-targeting interfering peptide M1-20 was obtained. M1-20 has the potential to be developed as an anti-cancer drug candidate targeting FOXM1.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Shengwei Zhang, Jing Wang, Weichao Hu, Lijiao He, Qingyun Tang, Jie Li, Mengmeng Jie, Xinzhe Li, Cheng Liu, Ouyang Qin, Shiming Yang, Changjiang Hu
Summary: This study demonstrates that RNF112 suppresses the progression of gastric cancer by ubiquitinating FOXM1, and highlights the RNF112/FOXM1 axis as both a prognostic biomarker and a therapeutic target in gastric cancer. Furthermore, the small-molecule compound RCM-1 enhances the interaction between RNF112 and FOXM1, promoting FOXM1 ubiquitination and exerting promising anticancer effects in vitro and in vivo.
Article
Multidisciplinary Sciences
Jessica Whitburn, Srinivasa R. Rao, Emma Morris, Sho Tabata, Akiyoshi Hirayama, Tomoyoshi Soga, James R. Edwards, Zeynep Kaya, Charlotte Palmer, Freddie C. Hamdy, Claire M. Edwards
Summary: The energy requirements of prostate cancer cells change in the bone microenvironment, with the pentose phosphate pathway (PPP) and glucose-6-phosphate dehydrogenase (G6PD) playing a crucial role in bone metastasis. Inhibition of G6PD can reduce prostate cancer growth and migration, and increase chemosensitivity.
Article
Biology
Lianggang Huang, Xuejie Li, Liangbo Dong, Bin Wang, Li Pan
Summary: This study established an ATAC-seq platform for filamentous fungi, generating valuable data on chromatin accessibility regions and transcription factor binding sites across different conditions and TF-deleted strains, laying the foundation for further investigation into transcriptional regulation in filamentous fungi.
Article
Plant Sciences
Yi Wu, Fangbin Cao, Lupeng Xie, Feibo Wu, Shenlong Zhu, Chengwei Qiu
Summary: Aluminum toxicity is a major constraint to crop production in acidic soils. This study investigated the changes in miRNA expression in the roots of two olive genotypes with contrasting aluminum tolerance. A total of 352 miRNAs were discovered, and 11 miRNAs showed significantly different expression patterns between the tolerant and sensitive genotypes under aluminum stress. In silico prediction identified potential target genes involved in transcriptional regulation, hormone signaling, transportation, and metabolism. These findings provide new insights into the regulatory roles of miRNAs in enhancing aluminum tolerance in olives.
Article
Plant Sciences
Ruixue Jia, Rong Zhang, Sunil S. Gangurde, Chaochen Tang, Bingzhi Jiang, Guilan Li, Zhangying Wang
Summary: In this study, an integrated analysis of metabolomic and transcriptomic was performed to investigate carotenoid metabolism and regulatory mechanisms in sweetpotato tuberous roots of different colors. The results showed that different colored sweetpotatoes contain different compositions of carotenoids, and key genes and transcription factors highly associated with carotenoid content were identified.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter, Remco Nagel, Jin Ma, Abhijeet Pataskar, Gozde Korkmaz, Ran Elkon, Miao-Ping Chien, Li You, Pin-Rui Su, Onno B. Bleijerveld, Maarten Altelaar, Lyubomir Momchev, Zohar Manber, Ruiqi Han, Pieter C. van Breugel, Rui Lopes, Peter ten Dijke, Jacco van Rheenen, Reuven Agami
Summary: YAP, a transcription co-factor, binds to thousands of enhancer loci to stimulate tumor aggressiveness. Through unbiased functional approaches, researchers identified and characterized TRAM2 as a novel mediator of cellular proliferation, migration, and invasion induced by YAP. These findings help elucidate the mechanisms by which YAP promotes cancer aggressiveness and may aid in cancer metastasis diagnosis.
Article
Biochemistry & Molecular Biology
Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Parameswaran Hari, Siegfried Janz
Summary: FOXM1 plays a crucial role in myeloma metabolism by regulating glycolysis and oxidative phosphorylation pathways. Inhibiting FOXM1 can effectively suppress myeloma growth, offering potential new approaches for therapy and prevention.
Article
Multidisciplinary Sciences
Georgia M. Lorentzen, Pawel Laniewski, Haiyan Cui, Denise J. Rose, Jamal Mouard, Nichole D. Marnert, Leslie Farland, Melissa M. Herbst-Kralovetz
Summary: Adenomyosis is a burdensome gynecologic condition that often goes undiagnosed despite its negative impact on quality of life. In this study, we used non-invasive cervicovaginal lavage samples to analyze the levels of immune proteins and metabolites in women with adenomyosis. We found significant alterations in immune proteins and a large quantity of metabolites related to cytokines and amino acids. Through enrichment analysis, we identified upregulated pathways in adenomyosis related to pyrimidine metabolism, carnitine synthesis, and histidine/histamine metabolism. This study demonstrates the usefulness of non-invasive sampling combined with immunometabolic profiling for adenomyosis detection and a better understanding of its pathophysiology.
Article
Medicine, Research & Experimental
Ipshita Nandi, Harvey W. Smith, Virginie Sanguin-Gendreau, Linjia Ji, Alain Pacis, Vasilios Papavasiliou, Dongmei Zuo, Stella Nam, Sherif S. Attalla, Sung Hoon Kim, Sierra Lusson, Hellen Kuasne, Anne -Marie Fortier, Paul Savage, Constanza Martinez Ramirez, Morag Park, John A. Katzenellenbogen, Benita S. Katzenellenbogen, William J. Muller
Summary: Activation of c-Src promotes breast cancer progression by phosphorylating FOXM1 on 2 tyrosine residues, stimulating its nuclear localization and target gene expression. The positive feedback loop formed by c-Src and FOXM1 drives proliferation in luminal B-like breast cancer. Targeting this mechanism induces cell-cycle arrest, apoptosis, and blocks tumor progression in luminal breast cancers.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Wenqi Qin, Ning Wang, Qi Yin, Huiling Li, Ai-Min Wu, Genji Qin
Summary: Increases in recorded high temperatures are causing changes in plant growth and decreasing crop productivity. A study has identified ABT1/WRKY14 as a critical repressor of plant thermomorphogenesis and proposed that ABT1/WRKY14, TCP5, and PIF4 form a regulatory module to fine-tune PIF4 activity and temperature-dependent plant growth.
Article
Clinical Neurology
Stephen T. Magill, Seunggu J. Han, Jing Li, Mitchel S. Berger
JOURNAL OF NEUROSURGERY
(2018)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Javier E. Villanueva-Meyer, Stephen T. Magill, Julieann C. Lee, Sarah E. Umetsu, Robert R. Flavell
CLINICAL NUCLEAR MEDICINE
(2018)
Article
Oncology
William C. Chen, Jared Hara, Stephen T. Magill, Ashley Wu, Manish K. Aghi, Philip V. Theodosopoulos, Arie Perry, Michael W. McDermott, Penny K. Sneed, David R. Raleigh, Steve E. Braunstein
JOURNAL OF NEURO-ONCOLOGY
(2018)
Article
Clinical Neurology
William C. Chen, Stephen T. Magill, Ashley Wu, Harish N. Vasudevan, Olivier Morin, Manish K. Aghi, Philip V. Theodosopoulos, Arie Perry, Michael W. McDermott, Penny K. Sneed, Steve E. Braunstein, David R. Raleigh
JOURNAL OF NEUROSURGERY
(2019)
Article
Clinical Neurology
Stephen T. Magill, Jacob S. Young, Ricky Chae, Manish K. Aghi, Philip V. Theodosopoulos, Michael W. McDermott
NEUROSURGICAL FOCUS
(2018)
Article
Clinical Neurology
Stephen T. Magill, Ramin A. Morshed, Calixto-Hope G. Lucas, Manish K. Aghi, Philip V. Theodosopoulos, Mitchel S. Berger, Oreste de Divitiis, Domenico Solari, Paolo Cappabianca, Luigi M. Cavallo, Michael W. McDermott
NEUROSURGICAL FOCUS
(2018)
Article
Clinical Neurology
Stephen T. Magill, Jonathan W. Rick, William C. Chen, David A. Haase, David R. Raleigh, Manish K. Aghi, Philip V. Theodosopoulos, Michael W. McDermott
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Ashley Wu, Michael A. Garcia, Stephen T. Magill, William Chen, Harish N. Vasudevan, Arie Perry, Philip V. Theodosopoulos, Michael W. McDermott, Steve E. Braunstein, David R. Raleigh
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Cecilia L. Dalle Ore, Christopher P. Ames, Stephen T. Magill, Vedat Deviren, Manish K. Aghi, Darryl Lau
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Stephen T. Magill, Maryam N. Shahin, Calixto-Hope G. Lucas, Adam J. Yen, David S. Lee, David R. Raleigh, Manish K. Aghi, Philip V. Theodosopoulos, Michael W. McDermott
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2019)
Article
Multidisciplinary Sciences
Efstathios D. Gennatas, Ashley Wu, Steve E. Braunstein, Olivier Morin, William C. Chen, Stephen T. Magill, Chetna Gopinath, Javier E. Villaneueva-Meyer, Arie Perry, Michael W. McDermott, Timothy D. Solberg, Gilmer Valdes, David R. Raleigh
Article
Oncology
Maryam N. Shahin, Stephen T. Magill, Cecilia L. Dalle Ore, Jennifer A. Viner, Pamela N. Peters, David A. Solomon, Michael W. McDermott
JOURNAL OF NEURO-ONCOLOGY
(2019)
Article
Clinical Neurology
Claire M. Faltermeier, Stephen T. Magill, Lewis S. Blevins, Manish K. Aghi
NEUROSURGERY CLINICS OF NORTH AMERICA
(2019)
Article
Clinical Neurology
Stephen T. Magill, Cecilia L. Dalle Ore, Michael A. Diaz, Daara D. Jalili, David R. Raleigh, Manish K. Aghi, Philip Theodosopoulos, Michael W. McDermott
JOURNAL OF NEUROSURGERY
(2019)