Journal
JOURNAL OF NEUROSURGERY
Volume 125, Issue 3, Pages 525-535Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2015.6.JNS15591
Keywords
meningioma; genomics; tumor classification; tumor progression; molecular taxonomy; precision medicine; targeted therapy; oncology
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Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.
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