Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens

Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity

(2014) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Dendritic cells as targets or therapeutics in rheumatic autoimmune disease

(2014) Ranjeny Thomas   CURRENT OPINION IN RHEUMATOLOGY

PTPN22 Controls the Germinal Center by Influencing the Numbers and Activity of T Follicular Helper Cells

(2014) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

(2014) Jan Petersen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protective Effect of the HLA-DRB1*13:02 Allele in Japanese Rheumatoid Arthritis Patients

(2014) Shomi Oka et al.   PLoS One

Identification of Self-antigen–specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis

(2014) Soi-Cheng Law et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

First report of improvement of coeliac disease in a patient with Sjogren's syndrome treated with rituximab

(2014) E. Nikiphorou et al.   RHEUMATOLOGY

Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population

(2014) Chikashi Terao et al.   ARTHRITIS CARE & RESEARCH

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

(2014) Eddie A. James et al.   Arthritis & Rheumatology

Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge

(2014) Asbjørn Christophersen et al.   United European Gastroenterology Journal

Porphyromonas gingivalis peptidylarginine deiminase substrate specificity

(2013) Syatirah-Najmi Abdullah et al.   ANAEROBE

Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis

(2013) Priscilla F Kerkman et al.   ANNALS OF THE RHEUMATIC DISEASES

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins

(2013) Aase Haj Hensvold et al.   ANNALS OF THE RHEUMATIC DISEASES

Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease

(2013) Michael Bodd et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Biased usage and preferred pairing of  - and  -chains of TCRs specific for an immunodominant gluten epitope in coeliac disease

(2013) S.-W. Qiao et al.   INTERNATIONAL IMMUNOLOGY

The pathogenesis of neonatal autoimmune and autoinflammatory diseases: A comprehensive review

(2013) Christopher Chang   JOURNAL OF AUTOIMMUNITY

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

(2013) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7- and IL-15-Mediated TCR Sensitization Enables T Cell Responses to Self-Antigens

(2013) P. Deshpande et al.   JOURNAL OF IMMUNOLOGY

Increased production of interleukin-21, but not interleukin-17A, in the small intestine characterizes pediatric celiac disease

(2013) M A van Leeuwen et al.   Mucosal Immunology

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Erosive Rheumatoid Arthritis Is Associated with Antibodies That Activate PAD4 by Increasing Calcium Sensitivity

(2013) E. Darrah et al.   Science Translational Medicine

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease

(2012) P L Klarenbeek et al.   ANNALS OF THE RHEUMATIC DISEASES

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis

(2012) Omri Snir et al.   ARTHRITIS AND RHEUMATISM

Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease

(2012) Sophie E. Broughton et al.   IMMUNITY

Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules

(2012) Ludvig M. Sollid et al.   IMMUNOGENETICS

A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned

(2012) Stephanie Gras et al.   IMMUNOLOGICAL REVIEWS

Structural basis for self-recognition by autoimmune T-cell receptors

(2012) Yiyuan Yin et al.   IMMUNOLOGICAL REVIEWS

Rituximab: An effective treatment for rheumatologic and digestive symptoms of celiac disease?

(2012) Clémence Palazzo et al.   JOINT BONE SPINE

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

(2012) Roberto Di Niro et al.   NATURE MEDICINE

The influence of ACPA status and characteristics on the course of RA

(2012) Annemiek Willemze et al.   Nature Reviews Rheumatology

Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns

(2012) L. A. van de Stadt et al.   RHEUMATOLOGY

From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases

(2012) Vinod Kumar et al.   Seminars in Immunopathology

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

(2012) Soi Law et al.   ARTHRITIS RESEARCH & THERAPY

Fc  receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins

(2011) L. Laurent et al.   ANNALS OF THE RHEUMATIC DISEASES

Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis

(2011) Valérie Abadie et al.   Annual Review of Immunology

Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

(2011) Lotte A. van de Stadt et al.   ARTHRITIS AND RHEUMATISM

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Structure-Based Selection of Small Molecules To Alter Allele-Specific MHC Class II Antigen Presentation

(2011) A. W. Michels et al.   JOURNAL OF IMMUNOLOGY

Posttranslational Modification of Gluten Shapes TCR Usage in Celiac Disease

(2011) S.-W. Qiao et al.   JOURNAL OF IMMUNOLOGY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

Anti-CCP antibodies: the past, the present and the future

(2011) Walther J. van Venrooij et al.   Nature Reviews Rheumatology

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia

(2010) L. A. van de Stadt et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities

(2010) A. Ioan-Facsinay et al.   ANNALS OF THE RHEUMATIC DISEASES

Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: A meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein

(2010) Diane van der Woude et al.   ARTHRITIS AND RHEUMATISM

The continuous measurement of anti-CCP-antibodies does not help to evaluate the disease activity in anti-CCP-antibody-positive patients with rheumatoid arthritis

(2010) Thoren Landmann et al.   CLINICAL RHEUMATOLOGY

Celiac disease: how complicated can it get?

(2010) Jennifer May-Ling Tjon et al.   IMMUNOGENETICS

HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22

(2010) M Bodd et al.   Mucosal Immunology

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

(2010) J. A. Tye-Din et al.   Science Translational Medicine

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Identification of citrullinated vimentin peptides as T cell epitopes in HLA–DR4–positive patients with rheumatoid arthritis

(2009) Anouk L. Feitsma et al.   ARTHRITIS AND RHEUMATISM

Profiling of rheumatoid arthritis associated autoantibodies

(2009) Karsten Conrad et al.   AUTOIMMUNITY REVIEWS

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis

(2009) Hüseyin Uysal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Post-translationally modified T cell epitopes: immune recognition and immunotherapy

(2009) Jan Petersen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Antibodies Against Deamidated Gliadin as New and Accurate Biomarkers of Childhood Coeliac Disease

(2009) Christian Prause et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

(2009) Lars-Egil Fallang et al.   NATURE IMMUNOLOGY

Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease

(2008) Andreea Ioan-Facsinay et al.   ARTHRITIS AND RHEUMATISM

Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease

(2007) D Fina et al.   GUT