Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells

CAR-T cell therapy: current limitations and potential strategies

(2021) Robert C. Sterner et al.   Blood Cancer Journal

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

Recent Advances in Allogeneic CAR-T Cells

(2020) Dong Wook Kim et al.   Biomolecules

Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms

(2020) Rong En Tay et al.   CANCER GENE THERAPY

Click cross-linking improves retention and targeting of refillable alginate depots

(2020) Christopher T. Moody et al.   Acta Biomaterialia

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma

(2020) Carlos A. Ramos et al.   JOURNAL OF CLINICAL ONCOLOGY

Scaffold‐Mediated Static Transduction of T Cells for CAR‐T Cell Therapy

(2020) Pritha Agarwalla et al.   Advanced Healthcare Materials

The stability of envelope-pseudotyped lentiviral vectors

(2020) Iris J. C. Dautzenberg et al.   GENE THERAPY

Chimeric antigen receptor T cell persistence and memory cell formation

(2019) Alexander D McLellan et al.   IMMUNOLOGY AND CELL BIOLOGY

In vivo generated human CAR T cells eradicate tumor cells

(2019) Shiwani Agarwal et al.   OncoImmunology

Preclinical safety evaluation of chimeric antigen receptor-modified T cells against CD19 in NSG mice

(2019) Hairuo Wen et al.   Annals of Translational Medicine

Influence of retronectin-mediated T cell activation on expansion and phenotype of CD19-specific chimeric antigen receptor T cells

(2018) Sophia Stock et al.   HUMAN GENE THERAPY

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

(2018) Alexander S Cheung et al.   NATURE BIOTECHNOLOGY

The global landscape of cancer cell therapy

(2018) Jun Tang et al.   NATURE REVIEWS DRUG DISCOVERY

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells

(2018) Saba Ghassemi et al.   Cancer Immunology Research

National Coverage Analysis of CAR-T Therapies — Policy, Evidence, and Payment

(2018) Peter B. Bach   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Antigen Escape from CAR T-cell Therapy

(2018) Robbie G. Majzner et al.   Cancer Discovery

Chimeric antigen receptors: unleashing a new age of anti-cancer therapy

(2018) Yan Leyfman   Cancer Cell International

Clinical and immunological responses after CD30-specific chimeric antigen receptor–redirected lymphocytes

(2017) Carlos A. Ramos et al.   JOURNAL OF CLINICAL INVESTIGATION

Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells

(2017) Iulia Diaconu et al.   MOLECULAR THERAPY

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Immunotherapy: Tisagenlecleucel — the first approved CAR-T-cell therapy: implications for payers and policy makers

(2017) Vinay Prasad   Nature Reviews Clinical Oncology

OpenPNM: A Pore Network Modeling Package

(2016) Jeff Gostick et al.   COMPUTING IN SCIENCE & ENGINEERING

Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy

(2016) Ulrike Mock et al.   CYTOTHERAPY

Glycolysis determines dichotomous regulation of T cell subsets in hypoxia

(2016) Yang Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical responses with T lymphocytes targeting malignancy-associated κ light chains

(2016) Carlos A. Ramos et al.   JOURNAL OF CLINICAL INVESTIGATION

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications

(2016) Irina N. Savina et al.   Scientific Reports

A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies

(2016) Tangying Lily Lu et al.   Human Gene Therapy Methods

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

(2015) Zeguo Zhao et al.   CANCER CELL

In Vivo Targeting through Click Chemistry

(2015) Yevgeny Brudno et al.   ChemMedChem

Selection bias: maintaining less-differentiated T cells for adoptive immunotherapy

(2015) Yang Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

(2014) Y. Xu et al.   BLOOD

CD19-CAR Trials

(2014) Carlos A. Ramos et al.   CANCER JOURNAL

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients

(2011) Barbara Savoldo et al.   JOURNAL OF CLINICAL INVESTIGATION

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering

(2010) Chang Mo Hwang et al.   Biofabrication

Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors

(2008) Yuki Hori et al.   Acta Biomaterialia

Engineering of a Stable Retroviral Gene Delivery Vector by Directed Evolution

(2007) Halong N Vu et al.   MOLECULAR THERAPY