Rhein Improves Renal Fibrosis by Restoring Cpt1a-Mediated Fatty Acid Oxidation through SirT1/STAT3/twist1 Pathway

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

(2021) Verónica Miguel et al.   JOURNAL OF CLINICAL INVESTIGATION

Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF-κB signaling

(2021) Meiyou Liu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies

(2021) Sara Lovisa   Frontiers in Pharmacology

Effects of Acanthopanax senticosus (Rupr. & Maxim.) Harms on cerebral ischemia-reperfusion injury revealed by metabolomics and transcriptomics

(2020) Ren-hao Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis

(2020) Sara Lovisa et al.   Science Signaling

What we already know about rhubarb: a comprehensive review

(2020) Hong Xiang et al.   Chinese Medicine

New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2020) Lili Sheng et al.   Frontiers in Physiology

Renal Inflammation and Fibrosis: A Double-edged Sword

(2019) Laurence M. Black et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Molecular determinants of mesenchymal cell activation in fibroproliferative diseases

(2019) Loka R. Penke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Management of diabetic nephropathy: the role of sirtuin-1

(2019) Wanning Wang et al.   Future Medicinal Chemistry

Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset

(2019) Otsuki et al.   MOLECULES

A Significant Association Between Rhein and Diabetic Nephropathy in Animals: A Systematic Review and Meta-Analysis

(2019) Heng-Chang Hu et al.   Frontiers in Pharmacology

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Renal fibrosis: Primacy of the proximal tubule

(2018) Leslie S. Gewin   MATRIX BIOLOGY

Global Cardiovascular and Renal Outcomes of Reduced GFR

(2017) Bernadette Thomas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

What can target kidney fibrosis?

(2017) Irina A Leaf et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis

(2016) Katrin Palumbo-Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Prognostic Value of Tubulointerstitial Lesions, Urinary N-Acetyl- -D-Glucosaminidase, and Urinary  2-Microglobulin in Patients with Type 2 Diabetes and Biopsy-Proven Diabetic Nephropathy

(2016) K. Mise et al.   Clinical Journal of the American Society of Nephrology

Partial Epithelial-to-Mesenchymal Transition and Other New Mechanisms of Kidney Fibrosis

(2016) Sara Lovisa et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

Cyclic Nucleotide Signalling in Kidney Fibrosis

(2015) Elisabeth Schinner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion

(2013) Kyung Hwa Cho et al.   CANCER LETTERS

Rhein Inhibits Integrin-Linked Kinase Expression and Regulates Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio in High Glucose-Induced Epithelial-Mesenchymal Transition of Renal Tubular Cell

(2012) Linlin Peng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue

(2012) Anca D. Dobrian   Frontiers in Endocrinology

Preventive Effects and Mechanisms of Rhein on Renal Interstitial Fibrosis in Obstructive Nephropathy

(2011) Dongyuan He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms

(2011) Qian Qin et al.   CELL RESEARCH

Tubulointerstitial injury and the progression of chronic kidney disease

(2011) Kavita S. Hodgkins et al.   PEDIATRIC NEPHROLOGY

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

(2009) Yongzhan Nie et al.   NATURE CELL BIOLOGY