Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

(2021) Hong Sun et al.   Cell Reports

Anterograde Viral Tracer HSV-1 Strain H129 Transports Primarily as Capsids in Cortical Neuron Axons

(2020) Xiao Dong et al.   JOURNAL OF VIROLOGY

Host-mediated ubiquitination of a mycobacterial protein suppresses immunity

(2020) Lin Wang et al.   NATURE

Human DNA-PK activates a STING-independent DNA sensing pathway

(2020) Katelyn Burleigh et al.   Science Immunology

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

(2020) Li Zhong et al.   Cell Discovery

Structural basis for nucleosome-mediated inhibition of cGAS activity

(2020) Duanfang Cao et al.   CELL RESEARCH

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

(2020) Chiho Kim et al.   eLife

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

(2020) Xiaona Sun et al.   Nature Communications

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids

(2019) Chenglong Sun et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

A decade of clinical development of PARP inhibitors in perspective

(2019) J Mateo et al.   ANNALS OF ONCOLOGY

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

MORC2 regulates DNA damage response through a PARP1-dependent pathway

(2019) Lin Zhang et al.   NUCLEIC ACIDS RESEARCH

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

(2019) Derek J Royer et al.   eLife

Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation

(2019) Shuai Wang et al.   Nature Chemical Biology

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

(2018) Zhiming Li et al.   CELL RESEARCH

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion

(2018) Pengyan Xia et al.   IMMUNITY

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

(2018) Siyuan Ding et al.   Nature Communications

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

Virus DNA Replication and the Host DNA Damage Response

(2018) Matthew D. Weitzman et al.   Annual Review of Virology

The comings and goings of PARP-1 in response to DNA damage

(2018) John M. Pascal   DNA REPAIR

Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity

(2018) Cheng Wang et al.   Cell Death & Disease

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

(2018) Jianfeng Shen et al.   CANCER RESEARCH

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

(2018) Roman M. Chabanon et al.   JOURNAL OF CLINICAL INVESTIGATION

The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication

(2017) Terri G. Edwards et al.   JOURNAL OF VIROLOGY

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity

(2017) Xin Luo et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

(2017) Geneviève Pépin et al.   mBio

A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

(2017) Abigail J Morales et al.   eLife

The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3

(2016) Yilong Zhou et al.   NATURE IMMUNOLOGY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Molecular Basis of Regulating High Voltage-Activated Calcium Channels byS-Nitrosylation

(2015) Meng-Hua Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP1 911

(2015) Florian J Bock et al.   Nature Chemical Biology

HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain

(2015) Douglas R. Wilcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

(2015) Megan H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

(2015) Gil Ju Seo et al.   Cell Reports

Reactive oxygen and nitrogen species during viral infections

(2014) C. G. Molteni et al.   FREE RADICAL RESEARCH

Inhibition of the Cardiac Na+Channel Nav1.5 by Carbon Monoxide

(2014) Jacobo Elies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

NESmapper: Accurate Prediction of Leucine-Rich Nuclear Export Signals Using Activity-Based Profiles

(2014) Shunichi Kosugi et al.   PLoS Computational Biology

ROS inhibitorN-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

(2013) Marianna Halasi et al.   BIOCHEMICAL JOURNAL

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

(2013) K. A. Horan et al.   JOURNAL OF IMMUNOLOGY

Poly(ADP-Ribose) Polymerase 1 Promotes Oxidative-Stress-Induced Liver Cell Death via Suppressing Farnesoid X Receptor α

(2013) Cheng Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

PARP-1 and gene regulation: Progress and puzzles

(2013) W. Lee Kraus et al.   MOLECULAR ASPECTS OF MEDICINE

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

(2013) Stephanie Jungmichel et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome

(2013) Yajie Zhang et al.   NATURE METHODS

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus

(2013) Nicholas E. Peters et al.   PLoS Pathogens

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

ValidNESs: a database of validated leucine-rich nuclear export signals

(2012) Szu-Chin Fu et al.   NUCLEIC ACIDS RESEARCH

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

(2010) Hiroki Ishikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY