Combining radiation with PI3K isoform-selective inhibitor administration increases radiosensitivity and suppresses tumor growth in non-small cell lung cancer
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Title
Combining radiation with PI3K isoform-selective inhibitor administration increases radiosensitivity and suppresses tumor growth in non-small cell lung cancer
Authors
Keywords
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Journal
JOURNAL OF RADIATION RESEARCH
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2022-04-14
DOI
10.1093/jrr/rrac018
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Note: Only part of the references are listed.- IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer
- (2021) Mai Badarni et al. Cancers
- Phase I, open-label, multicentre study of buparlisib in combination with temozolomide or with concomitant radiation therapy and temozolomide in patients with newly diagnosed glioblastoma
- (2020) Patrick Yung Wen et al. ESMO Open
- The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer
- (2020) Liying Ma et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma
- (2019) Daniel R. McGowan et al. EUROPEAN JOURNAL OF CANCER
- Management of toxicity to isoform α-specific PI3K inhibitors
- (2019) S E Nunnery et al. ANNALS OF ONCOLOGY
- Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer Cells
- (2018) Klaudia Szymonowicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer
- (2018) Jonatan Zorea et al. Cell Death & Disease
- Clinically relevant radioresistant cell line: a simple model to understand cancer radioresistance
- (2017) Yoshikazu Kuwahara et al. Medical Molecular Morphology
- NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression
- (2017) Junyi Ju et al. Nature Communications
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Low-Dose Radiation Induces Cell Proliferation in Human Embryonic Lung Fibroblasts but not in Lung Cancer Cells
- (2016) Xinyue Liang et al. Dose-Response
- PI3K inhibitors as new cancer therapeutics: implications for clinical trial design
- (2016) Cristian Massacesi et al. OncoTargets and Therapy
- Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer
- (2016) Mahmoud Toulany et al. Oncotarget
- Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells
- (2016) Marina Holler et al. PLoS One
- PI3K isoform-selective inhibitors: next-generation targeted cancer therapies
- (2015) Xiang Wang et al. ACTA PHARMACOLOGICA SINICA
- Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
- (2015) Carlotta Costa et al. CANCER CELL
- Global Cancer Incidence and Mortality Rates and Trends--An Update
- (2015) L. A. Torre et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Taselisib (GDC-0032), a Potent -Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
- (2015) Z. S. Zumsteg et al. CLINICAL CANCER RESEARCH
- The PI3K/AKT/mTOR interactive pathway
- (2015) Tulin Ersahin et al. Molecular BioSystems
- A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition
- (2015) Wenting Xu et al. Cell Adhesion & Migration
- The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses
- (2015) Bipasha Mukherjee et al. NEOPLASIA
- Radiation-enhanced cell migration/invasion process: A review
- (2014) Coralie Moncharmont et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation
- (2014) Arghya Adhikary et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- EMT Twists the Road to PI3K
- (2014) M. J. Niederst et al. Cancer Discovery
- Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy
- (2013) M.E. Lomax et al. CLINICAL ONCOLOGY
- Rhamnetin and Cirsiliol Induce Radiosensitization and Inhibition of Epithelial-Mesenchymal Transition (EMT) by miR-34a-mediated Suppression of Notch-1 Expression in Non-small Cell Lung Cancer Cell Lines
- (2013) JiHoon Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes
- (2013) Roberto Gomez-Casal et al. Molecular Cancer
- Development of PI3K inhibitors: lessons learned from early clinical trials
- (2013) Jordi Rodon et al. Nature Reviews Clinical Oncology
- mTORC1 Inhibition Is Required for Sensitivity to PI3K p110 Inhibitors in PIK3CA-Mutant Breast Cancer
- (2013) M. Elkabets et al. Science Translational Medicine
- Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs-Dependent DNA Double-Strand Break Repair
- (2012) M. Toulany et al. MOLECULAR CANCER RESEARCH
- The EMT regulator slug and lung carcinogenesis
- (2011) J.-Y. Shih et al. CARCINOGENESIS
- MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks
- (2011) Michael Fraser et al. CELL CYCLE
- CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial–Mesenchymal Transition in HCC Cells
- (2011) Ai–Wu Ke et al. GASTROENTEROLOGY
- PI3K: A potential therapeutic target for cancer
- (2011) Yingwei Chen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
- (2011) Johanna C. Bendell et al. JOURNAL OF CLINICAL ONCOLOGY
- Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer Cells
- (2011) A. Azad et al. MOLECULAR CANCER RESEARCH
- E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells
- (2011) Jan Theys et al. RADIOTHERAPY AND ONCOLOGY
- Targeting Epidermal Growth Factor Receptor-Associated Signaling Pathways in Non-Small Cell Lung Cancer Cells: Implication in Radiation Response
- (2010) E. J. Choi et al. MOLECULAR CANCER RESEARCH
- PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation
- (2010) R Deng et al. ONCOGENE
- Vimentin is a novel AKT1 target mediating motility and invasion
- (2010) Q-S Zhu et al. ONCOGENE
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non-Small Cell Lung Cancer Harboring K-RAS Mutations
- (2009) G. Konstantinidou et al. CANCER RESEARCH
- The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer
- (2009) Olga C.J. Schuurbiers et al. Journal of Thoracic Oncology
- Receptor signaling as a regulatory mechanism of DNA repair
- (2009) Raymond E. Meyn et al. RADIOTHERAPY AND ONCOLOGY
- Class I PI3 Kinase Inhibition by the Pyridinylfuranopyrimidine Inhibitor PI-103 Enhances Tumor Radiosensitivity
- (2008) R. Prevo et al. CANCER RESEARCH
- Transforming Growth Factor Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab
- (2008) S. E. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
- Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
- (2008) M. Toulany et al. MOLECULAR CANCER THERAPEUTICS
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