Evaluation of in vitro Tools to Predict the in vivo Absorption of Biopharmaceuticals Following Subcutaneous Administration

Novel Applications of an In Vitro Injection Model System to Study Bioperformance: Case Studies with Different Drug Modalities

(2020) Sharadvi Thati et al.   Journal of Pharmaceutical Innovation

Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge

(2020) Manuel Sánchez-Félix et al.   ADVANCED DRUG DELIVERY REVIEWS

Pharmacokinetics of Anakinra in Subjects of Heavier Versus Lighter Body Weights

(2019) Bing‐Bing Yang et al.   CTS-Clinical and Translational Science

Tutorial on Monoclonal Antibody Pharmacokinetics and its Considerations in Early Development

(2018) Meric Ovacik et al.   CTS-Clinical and Translational Science

Hydrogels in three-dimensional dendritic cell (MUTZ-3) culture as a scaffold to mimic human immuno competent subcutaneous tissue

(2018) Floriane Groell et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

(2018) Hanne Kinnunen Bown et al.   JOURNAL OF CONTROLLED RELEASE

Challenges and Opportunities for the Subcutaneous Delivery of Therapeutic Proteins

(2018) Michael R. Turner et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice

(2018) Wolfgang F. Richter et al.   mAbs

Antibodies to watch in 2018

(2018) Hélène Kaplon et al.   mAbs

The role of subcutaneous tissue stiffness on microneedle performance in a representative in vitro model of skin

(2017) K. Moronkeji et al.   JOURNAL OF CONTROLLED RELEASE

Challenges in longitudinal exposure-response modeling of data from complex study designs: a case study of modeling CDAI score for ustekinumab in patients with Crohn’s disease

(2017) Chuanpu Hu et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Denosumab for the treatment of giant cell tumor of the bone

(2015) Thomas Brodowicz et al.   Future Oncology

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

(2015) Daniela Bumbaca Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

(2015) Hanne M. Kinnunen et al.   JOURNAL OF CONTROLLED RELEASE

Quantitative in vitro to in vivo extrapolation of tissues toxicity

(2015) Jérémy Hamon et al.   TOXICOLOGY IN VITRO

AB0269 Importance of steady-state trough concentrations after intravenous golimumab with concomitant methotrexate in patients with active rheumatoid arthritis

(2014) J. H. Leu et al.   ANNALS OF THE RHEUMATIC DISEASES

Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration

(2014) Anas M. Fathallah et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Insulin aspart pharmacokinetics: An assessment of its variability and underlying mechanisms

(2014) Christian Hove Rasmussen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase

(2013) O Shpilberg et al.   BRITISH JOURNAL OF CANCER

Certolizumab Pegol

(2013) Emma D. Deeks   DRUGS

High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

(2013) Yuqi Liu et al.   mAbs

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

Population Pharmacokinetic Analysis of Denosumab in Patients with Bone Metastases from Solid Tumours

(2012) Leonid Gibiansky et al.   CLINICAL PHARMACOKINETICS

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

Population Pharmacokinetic Meta-Analysis of Denosumab in Healthy Subjects and Postmenopausal Women with Osteopenia or Osteoporosis

(2011) Liviawati Sutjandra et al.   CLINICAL PHARMACOKINETICS

Golimumab Pharmacokinetics After Repeated Subcutaneous and Intravenous Administrations in Patients with Rheumatoid Arthritis and the Effect of Concomitant Methotrexate: An Open-Label, Randomized Study

(2011) Yanli Zhuang et al.   CLINICAL THERAPEUTICS

Ustekinumab

(2011) Jamie D. Croxtall   DRUGS

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

(2011) Timothy M. Lauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

(2010) Miguel Miron-Mendoza et al.   BIOMATERIALS

Skin and subcutaneous adipose layer thickness in adults with diabetes at sites used for insulin injections: implications for needle length recommendations

(2010) Michael A. Gibney et al.   CURRENT MEDICAL RESEARCH AND OPINION

Subcutaneous Bioavailability of Golimumab at 3 Different Injection Sites in Healthy Subjects

(2009) Zhenhua Xu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY