Imaging of Synaptic Density in Neurodegenerative Disorders

Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A

(2021) Songye Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

(2021) Ryan S. O’Dell et al.   Alzheimers Research & Therapy

In vivo tau pathology is associated with synaptic loss and altered synaptic function

(2021) Emma M. Coomans et al.   Alzheimers Research & Therapy

Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study

(2021) Ming-Kai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduced Synaptic Density in Patients with Lewy Body Dementia: An [ 11 C ] UCB‐J PET Imaging Study

(2021) Katrine B. Andersen et al.   MOVEMENT DISORDERS

Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study

(2021) Laura Michiels et al.   NEUROIMAGE

Changes in synaptic density in the subacute phase after ischemic stroke: A 11C-UCB-J PET/MR study

(2021) Laura Michiels et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Synaptic vesicle glycoprotein 2A is affected in the CNS of Huntington’s Disease mice and post-mortem human HD brain

(2021) Daniele Bertoglio et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo evidence of lower synaptic vesicle density in schizophrenia

(2021) Rajiv Radhakrishnan et al.   MOLECULAR PSYCHIATRY

In vivo exploration of synaptic projections in frontotemporal dementia

(2021) Eric Salmon et al.   Scientific Reports

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

(2021) Ellis Chika Onwordi et al.   Translational Psychiatry

Synaptic density in carriers of C9orf72 mutations: a [ 11 C]UCB‐J PET study

(2021) Maura Malpetti et al.   Annals of Clinical and Translational Neurology

Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11 C‐UCB‐J positron emission tomography study in humans

(2021) Gustavo A. Angarita et al.   ADDICTION BIOLOGY

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

(2021) Mengfei Xiong et al.   NEUROIMAGE

Synaptic Damage and Its Clinical Correlates in People With Early Huntington Disease

(2021) Aline Delva et al.   NEUROLOGY

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

(2021) Nakul Ravi Raval et al.   Frontiers in Synaptic Neuroscience

Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease

(2021) Adam P. Mecca et al.   NEUROBIOLOGY OF AGING

Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT-2

(2020) Zhengxin Cai et al.   ACS Chemical Neuroscience

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

(2020) David Matuskey et al.   ANNALS OF NEUROLOGY

In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET

(2020) Adam P. Mecca et al.   Alzheimers & Dementia

Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug‐Naive Parkinson's Disease

(2020) Heather Wilson et al.   MOVEMENT DISORDERS

Autoradiographic mapping of synaptic vesicle glycoprotein 2A in non‐human primate and human brain

(2020) Katarina Varnäs et al.   SYNAPSE

In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET

(2020) Majken B Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task

(2020) Kelly Smart et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort

(2020) Mika Naganawa et al.   JOURNAL OF NUCLEAR MEDICINE

Synaptic Loss in Primary Tauopathies Revealed by [ 11 C ] UCB‐J Positron Emission Tomography

(2020) Negin Holland et al.   MOVEMENT DISORDERS

Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease

(2020) Aline Delva et al.   MOVEMENT DISORDERS

In vivo synaptic density loss is related to tau deposition in amnestic mild cognitive impairment

(2020) Heleen Vanhaute et al.   NEUROLOGY

Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [ 11 C]UCB‐J positron emission tomography study

(2020) Sjoerd J. Finnema et al.   EPILEPSIA

First-in-human evaluation of 18F-SynVesT-1, a novel radioligand for PET imaging of synaptic vesicle protein 2A

(2020) Mika Naganawa et al.   JOURNAL OF NUCLEAR MEDICINE

Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder

(2020) Deepak Cyril D’Souza et al.   MOLECULAR PSYCHIATRY

A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers

(2019) Sjoerd J. Finnema et al.   EPILEPSIA

In vivo synaptic density imaging with 11C-UCB-J detects treatment effects of saracatinib (AZD0530) in a mouse model of Alzheimer’s disease.

(2019) Takuya Toyonaga et al.   JOURNAL OF NUCLEAR MEDICINE

Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A)

(2019) Songye Li et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Characterization of 3 PET tracers for Quantification of Mitochondrial and Synaptic function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, 11C-UCB-J

(2019) Ayla Mansur et al.   JOURNAL OF NUCLEAR MEDICINE

Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue

(2019) Nathalie Mertens et al.   MOLECULAR IMAGING AND BIOLOGY

Lower synaptic density is associated with depression severity and network alterations

(2019) Sophie E. Holmes et al.   Nature Communications

In vivo imaging of synaptic loss in Alzheimer’s disease with [18F]UCB-H positron emission tomography

(2019) Christine Bastin et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Assessment of a white matter reference region for 11C-UCB-J PET quantification

(2019) Samantha Rossano et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue

(2018) Michel Koole et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers

(2018) Cristian C. Constantinescu et al.   MOLECULAR IMAGING AND BIOLOGY

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates

(2018) Songye Li et al.   ACS Chemical Neuroscience

Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans

(2017) Sjoerd J Finnema et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacokinetic Characterization of [18F]UCB-H PET Radiopharmaceutical in the Rat Brain

(2017) Guillaume Becker et al.   MOLECULAR PHARMACEUTICS

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

Puzzling Out Synaptic Vesicle 2 Family Members Functions

(2017) Odile Bartholome et al.   Frontiers in Molecular Neuroscience

Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability

(2016) Martijn C. de Wilde et al.   Alzheimers & Dementia

Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent 18F-Labeled Ligand ([18F]UCB-H)

(2016) Corentin Warnier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain

(2016) N. B. Nabulsi et al.   JOURNAL OF NUCLEAR MEDICINE

[11C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A

(2016) Sergio Estrada et al.   NUCLEAR MEDICINE AND BIOLOGY

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

Relationship Between Alzheimer Disease-Like Pattern of 18F-FDG and Fasting Plasma Glucose Levels in Cognitively Normal Volunteers

(2015) K. Ishibashi et al.   JOURNAL OF NUCLEAR MEDICINE

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

(2015) Mikael Marttinen et al.   Molecular Neurodegeneration

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old

(2014) John L. Robinson et al.   BRAIN

Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands

(2014) Joël Mercier et al.   ChemMedChem

Evaluation of 18F-UCB-H as a Novel PET Tracer for Synaptic Vesicle Protein 2A in the Brain

(2014) G. I. Warnock et al.   JOURNAL OF NUCLEAR MEDICINE

Cognition in corticobasal syndrome and progressive supranuclear palsy: A review

(2014) James R. Burrell et al.   MOVEMENT DISORDERS

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Radiosynthesis of 11C-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression

(2014) Hancheng Cai et al.   ACS Medicinal Chemistry Letters

Synaptic vesicle protein 2A: basic facts and role in synaptic function

(2013) Julieta Griselda Mendoza-Torreblanca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions

(2013) C. M. Burns et al.   NEUROLOGY

Differential striatal spine pathology in Parkinson’s disease and cocaine addiction: A key role of dopamine?

(2013) R.M. Villalba et al.   NEUROSCIENCE

Preclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H

(2013) Florian Bretin et al.   EJNMMI Research

Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease

(2012) J. Nithianantharajah et al.   NEUROSCIENCE

Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties

(2011) Michel Gillard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Protein Quantification at the Single Vesicle Level Reveals That a Subset of Synaptic Vesicle Proteins Are Trafficked with High Precision

(2011) S. A. Mutch et al.   JOURNAL OF NEUROSCIENCE

Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts

(2011) Kurt A. Jellinger   MOVEMENT DISORDERS

SV2 regulates neurotransmitter release via multiple mechanisms

(2010) Amy Nowack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

(2009) Susan M. Landau et al.   NEUROBIOLOGY OF AGING