Metformin treatment rescues CD8+ T cell response to immune checkpoint inhibitor therapy in mice with NAFLD

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NASH limits anti-tumour surveillance in immunotherapy-treated HCC

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Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

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Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy

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XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

(2021) Aleksandra Deczkowska et al.   NATURE MEDICINE

Hepatocellular Carcinoma — Origins and Outcomes

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Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma

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Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Steatohepatitis Impairs T cell-directed Immunotherapies Against Liver Tumors in Mice

(2020) Bernd Heinrich et al.   GASTROENTEROLOGY

Metabolic regulation of T lymphocyte motility and migration

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Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

(2020) Julia Böhme et al.   Nature Communications

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

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From NASH to HCC: current concepts and future challenges

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Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

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A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

(2018) Takuma Tsuchida et al.   JOURNAL OF HEPATOLOGY

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

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Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research

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Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy

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Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations

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NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

High-fat Western diet–induced obesity contributes to increased tumor growth in mouse models of human colon cancer

(2016) Ann Marie O'Neill et al.   NUTRITION RESEARCH

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

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Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus

(2015) Olena Kamenyeva et al.   PLoS Pathogens

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

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A method for measuring mitochondrial mass and activity

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Sorafenib in Advanced Hepatocellular Carcinoma

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