Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists

Design, synthesis and biological evaluation of Tozadenant analogues as adenosine A2A receptor ligands

(2021) Dana R. Renk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Activity Studies of Istradefylline Derivatives Based on Adenine as A2A Receptor Antagonists

(2021) Yiyun Wang et al.   ACS Omega

Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity

(2021) Daniele Carvalho Nascimento et al.   IMMUNITY

Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A2A/A2B receptor antagonist

(2021) Katarzyna Dziedzic et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In silico development of adenosine A2B receptor antagonists for sickle cell disease

(2021) Anna Carolina Rocha da Silva et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Combination Therapy Comprising A2A/A2B and PD-1/PD-L1 Inhibitors for Treating Cancer

(2021) Ram W. Sabnis   ACS Medicinal Chemistry Letters

Adenosine receptor antagonists: Recent advances and therapeutic perspective

(2021) Anjali Saini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment

(2021) Francesca Hofer et al.   Cells

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents

(2020) Flavia Varano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A phase I, open-label, multicenter study to assess the safety, pharmacokinetics, and preliminary antitumor activity of AZD4635 both as monotherapy and in combination in patients with advanced solid malignancies: Results from prostate cancer patients (NCT02740985).

(2020) Emerson A. Lim et al.   JOURNAL OF CLINICAL ONCOLOGY

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation

(2020) Michał Załuski et al.   BIOORGANIC CHEMISTRY

Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

(2020) Fazhi Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine A2A receptor (A2A AR) antagonist

(2020) G. Lakshma Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters

(2020) Elisabetta Barresi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure–Activity Relationship Studies, and Enantiospecific Recognition

(2020) María Majellaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potentials of A2B adenosine receptor ligands: Current status and perspectives

(2019) Balakumar Chandrasekaran et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis and evaluation of methoxy substituted 2-benzoyl-1-benzofuran derivatives as lead compounds for the development adenosine A1 and/or A2A receptor antagonists

(2019) Helena D. Janse van Rensburg et al.   BIOORGANIC CHEMISTRY

Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A2A adenosine receptor ligands

(2019) Min Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A2B Adenosine Receptor and Cancer

(2019) Zhan-Guo Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A 2B receptor

(2018) Marco Betti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

(2018) Lisa Seitz et al.   INVESTIGATIONAL NEW DRUGS

PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

(2018) Fabiana Núñez et al.   Frontiers in Pharmacology

Novel non-xanthine antagonist of the A2B adenosine receptor: From HTS hit to lead structure

(2018) Michael Härter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor

(2017) Romain Duroux et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of3H,2H4, and14C-MK 3814 (preladenant)

(2017) D. Hesk et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

(2017) Tobias Weinert et al.   Nature Communications

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

(2015) Claudia Sorrentino et al.   Oncotarget

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti–PD-1 through Enhanced Antitumor T-cell Responses

(2015) Paul A. Beavis et al.   Cancer Immunology Research

The effect of adenosine on pro-inflammatory cytokine production by porcine T cells

(2011) Petra Ondrackova et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE