A2B Adenosine Receptor and Cancer

The Adenosine A G Protein-Coupled Receptor: Recent Advances and Therapeutic Implications

(2019) Elizabeth A. Vecchio et al.   PHARMACOLOGY & THERAPEUTICS

Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy

(2019) Shira Cohen et al.   Drug Design Development and Therapy

A2B Adenosine Receptor Antagonists with Picomolar Potency

(2019) Jie Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Correction: RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2019) Sherene Loi et al.   CLINICAL CANCER RESEARCH

The CD26/DPP4-inhibitor vildagliptin suppresses lung cancer growth via macrophage-mediated NK cell activity

(2019) J H Jang et al.   CARCINOGENESIS

CD73 Promotes Glioblastoma Pathogenesis and Enhances Its Chemoresistance via A2B Adenosine Receptor Signaling

(2019) Angela Yan et al.   JOURNAL OF NEUROSCIENCE

Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas

(2019) Xiaoqiang Sun et al.   Journal of Translational Medicine

Recent progress of adenosine receptor modulators in the development of anticancer chemotherapeutic agents

(2019) Sarapynbiang Marwein et al.   CURRENT PHARMACEUTICAL DESIGN

Adenosine receptors as novel targets for the treatment of various cancers

(2019) Bapi Gorain et al.   CURRENT PHARMACEUTICAL DESIGN

Cardioprotective role of APIP in myocardial infarction through ADORA2B

(2019) Bitna Lim et al.   Cell Death & Disease

On the G protein-coupling selectivity of the native A 2B adenosine receptor

(2018) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Activation of adenosine A2b receptor attenuates high glucose-induced apoptosis in H9C2 cells via PI3K/Akt signaling

(2018) Yi Shen et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

A2AAdenosine Receptor Gene Deletion or Synthetic A2AAntagonist Liberate Tumor-Reactive CD8+T Cells from Tumor-Induced Immunosuppression

(2018) Jorgen Kjaergaard et al.   JOURNAL OF IMMUNOLOGY

Fluorescent-Labeled Selective Adenosine A2B Receptor Antagonist Enables Competition Binding Assay by Flow Cytometry

(2018) Meryem Köse et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Tritium-labeled agonists as tools for studying adenosine A2B receptors

(2018) Sonja Hinz et al.   Purinergic Signalling

The A2B Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells

(2018) Chiara Giacomelli et al.   Frontiers in Pharmacology

Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor

(2018) Marcel Lindemann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Infarct-sparing effect of adenosine A2B receptor agonist is primarily due to its action on splenic leukocytes via a PI3K/Akt/IL-10 pathway

(2018) Yingying Ni et al.   JOURNAL OF SURGICAL RESEARCH

The A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1

(2018) Marthe Koussémou et al.   PLoS One

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

(2018) Jie Lan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes

(2018) Elisabetta Barresi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers

(2018) Lisa Seitz et al.   INVESTIGATIONAL NEW DRUGS

HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis

(2017) Kemly Philip et al.   FASEB JOURNAL

The adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway

(2017) Yihong Zhou et al.   Oncotarget

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

(2017) Sarawuth Phosri et al.   Frontiers in Pharmacology

Leishmania amazonensis-Induced cAMP Triggered by Adenosine A2B Receptor Is Important to Inhibit Dendritic Cell Activation and Evade Immune Response in Infected Mice

(2017) Amanda Braga Figueiredo et al.   Frontiers in Immunology

Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression

(2016) Y. Sun et al.   BIOCHEMICAL JOURNAL

Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis

(2016) D. Mittal et al.   CANCER RESEARCH

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

(2016) Stephen M Hatfield et al.   CURRENT OPINION IN PHARMACOLOGY

Immunosuppressive activities of adenosine in cancer

(2016) Bertrand Allard et al.   CURRENT OPINION IN PHARMACOLOGY

Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration

(2016) Young Ou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes

(2016) Abdelaziz El Maatougui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of adenosine A2b receptor overexpression in tumor progression

(2016) Cesar Sepúlveda et al.   LIFE SCIENCES

Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

(2016) Patrycja Koszałka et al.   PLoS One

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells

(2016) Miriam Fernandez-Gallardo et al.   PLoS One

A2b adenosine signaling represses CIITA transcription via an epigenetic mechanism in vascular smooth muscle cells

(2015) Jun Xia et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Adenosine A2b receptor promotes progression of human oral cancer

(2015) Hiroki Kasama et al.   BMC CANCER

β-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells

(2015) Jessica M Wilson et al.   CANCER BIOLOGY & THERAPY

Adenosine A2B receptor stimulates angiogenesis by inducing VEGF and eNOS in human microvascular endothelial cells

(2015) Xiaolong Du et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence

(2015) Lili Jing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response

(2015) Heather B. Cohen et al.   JOURNAL OF IMMUNOLOGY

Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

(2015) Mohamad Wessam Alnouri et al.   Purinergic Signalling

Host A2B Adenosine Receptors Promote Carcinoma Growth

(2015) Sergey Ryzhov et al.   NEOPLASIA

A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin

(2015) Stefania Merighi et al.   NEOPLASIA

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

Probing biased/partial agonism at the G protein-coupled A2B adenosine receptor

(2014) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer

(2014) C. Zhao et al.   CANCER RESEARCH

The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor

(2014) Tian-zhu Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)

(2014) David Hoskin et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Human monocytes respond to extracellular cAMP through A2A and A2B adenosine receptors

(2014) Ester Sciaraffia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Potential Role of A2BAdenosine Receptors on Proliferation/Migration of Fetal Endothelium Derived from Preeclamptic Pregnancies

(2014) Jesenia Acurio et al.   Biomed Research International

Ligand-Specific Binding and Activation of the Human Adenosine A2B Receptor

(2013) Dominik Thimm et al.   BIOCHEMISTRY

Adenosine signaling inhibits CIITA-mediated MHC class II transactivation in lung fibroblast cells

(2013) Mingming Fang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

(2013) C. J. Desmet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A2B adenosine receptor blockade inhibits growth of prostate cancer cells

(2013) Qiang Wei et al.   Purinergic Signalling

Purinergic signalling and cancer

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

(2013) E. Ntantie et al.   Science Signaling

A Potential Role for Dendritic Cell/Macrophage-Expressing DPP4 in Obesity-Induced Visceral Inflammation

(2012) Jixin Zhong et al.   DIABETES

Adenosine A2B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells

(2011) Hiroko Nakatsukasa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells

(2011) Qiang Wei et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

(2011) C. Cekic et al.   JOURNAL OF IMMUNOLOGY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy

(2011) A. Kalhan et al.   Purinergic Signalling

Modulation of Innate Immunity by Adenosine Receptor Stimulation

(2011) Bart P. Ramakers et al.   SHOCK

Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells

(2010) De-Fu Ma et al.   HUMAN PATHOLOGY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist

(2010) Paul Eastwood et al.   ACS Medicinal Chemistry Letters

A2B adenosine receptors in immunity and inflammation

(2009) György Haskó et al.   TRENDS IN IMMUNOLOGY

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Major Histocompatibility Class II Transactivator Expression in Smooth Muscle Cells from A2b Adenosine Receptor Knock-out Mice

(2008) Yong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Novel A2BAdenosine Receptor Antagonist as a Clinical Candidate for Chronic Inflammatory Airway Diseases

(2008) Elfatih Elzein et al.   JOURNAL OF MEDICINAL CHEMISTRY