Design, synthesis and biological evaluation of novel scaffold benzo[4,5]imidazo [1,2-a]pyrazin-1-amine: Towards adenosine A2A receptor (A2A AR) antagonist

Adenosine A2A Receptor as a Potential Drug Target – Current Status and Future Perspectives

(2019) Omar Husham Ahmed Al-Attraqchi et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting A3 and A2A adenosine receptors in the fight against cancer

(2019) Stefania Merighi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain

(2019) Matteo Falsini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A2A receptor as potential therapeutic target in neuropsychiatric disorders

(2019) Maria Rosaria Domenici et al.   PHARMACOLOGICAL RESEARCH

Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A2A adenosine receptor ligands

(2019) Min Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A2A adenosine receptor agonists and their potential therapeutic applications. An update

(2018) Angel Guerrero   CURRENT MEDICINAL CHEMISTRY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Adenosine A2A Receptor Antagonists in Neurodegenerative Diseases: Huge Potential and Huge Challenges

(2018) Rafael Franco et al.   Frontiers in Psychiatry

Targeting adenosine for cancer immunotherapy

(2018) Robert D. Leone et al.   Journal for ImmunoTherapy of Cancer

Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson’s Disease: A Recent Update and Challenge

(2018) Jiyue Zheng et al.   ACS Chemical Neuroscience

A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models

(2018) Stephen B. Willingham et al.   Cancer Immunology Research

Targeting adenosine A2A receptor antagonism for treatment of cancer

(2018) Miles Congreve et al.   Expert Opinion on Drug Discovery

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

(2018) Kevin Sek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves

(2018) William G. Kerr et al.   JOURNAL OF IMMUNOLOGY

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes

(2017) Daniela Poli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype

(2017) Matteo Falsini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Human A 1 and A 2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

(2017) Robert K.Y. Cheng et al.   STRUCTURE

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

(2017) Tobias Weinert et al.   Nature Communications

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

(2016) Arabella Young et al.   CANCER CELL

Design, Synthesis, and Biological Evaluation of Novel 2-((2-(4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5′-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A2A Adenosine Receptor

(2015) Delia Preti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in development of imidazo[1,2-a]pyrazines: synthesis, reactivity and their biological applications

(2015) Richa Goel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

(2015) Robert D. Leone et al.   Computational and Structural Biotechnology Journal

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A3 adenosine receptor: Homology modeling and 3D-QSAR studies

(2013) Anna Maria Almerico et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors

(2012) Ori Kalid et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS