Alzheimer’s Disease and Tau Self-Assembly: In the Search of the Missing Link

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

(2021) Yang Shi et al.   ACTA NEUROPATHOLOGICA

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease

(2021) Rashid Waseem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

(2020) Anas Shamsi et al.   Biomolecules

Role of tau protein in Alzheimer's disease: The prime pathological player

(2020) Shibi Muralidar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease

(2020) Ricardo B. Maccioni et al.   JOURNAL OF ALZHEIMERS DISEASE

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease

(2020) Nabil Itzi Luna-Viramontes et al.   Frontiers in Cellular Neuroscience

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions

(2020) Mengyu Liu et al.   Scientific Reports

Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer’s drug Donepezil with human transferrin: Implications of Alzheimer’s drug

(2019) Anas Shamsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

CDK5: A Unique CDK and Its Multiple Roles in the Nervous System

(2019) Nicole Cortés et al.   JOURNAL OF ALZHEIMERS DISEASE

Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding

(2019) Sanjula P. Wickramasinghe et al.   BIOPHYSICAL JOURNAL

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

(2019) Ciaran P.C. Galts et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Is AD a Stress-Related Disorder? Focus on the HPA Axis and Its Promising Therapeutic Targets

(2019) Geoffrey Canet et al.   Frontiers in Aging Neuroscience

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

(2019) Leonardo Guzman-Martinez et al.   Frontiers in Pharmacology

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults

(2018) Nancy J. Donovan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Behavioral and Neuropsychiatric Disorders in Alzheimer’s Disease

(2018) Nicole Cortés et al.   JOURNAL OF ALZHEIMERS DISEASE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Ying Cheng et al.   Frontiers in Neuroscience

Resolution of inflammation and mood disorders

(2018) Dmiry V. Chistyakov et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Tau Oligomers and Fibrils Induce Activation of Microglial Cells

(2018) Inelia Morales et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular Pathogenesis of the Tauopathies

(2018) Jürgen Götz et al.   Annual Review of Pathology-Mechanisms of Disease

The Natural Product Curcumin as a Potential Coadjuvant in Alzheimer’s Treatment

(2017) Inelia Morales et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

(2017) Nona Abolhassani et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Absence of CX3CR1 impairs the internalization of Tau by microglia

(2017) Marta Bolós et al.   Molecular Neurodegeneration

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The Damage Signals Hypothesis of Alzheimer's Disease Pathogenesis

(2017) Jorge A. Fernández et al.   JOURNAL OF ALZHEIMERS DISEASE

Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes

(2015) Ke Hao et al.   MOLECULAR ASPECTS OF MEDICINE

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

(2013) Nguyen-Vi Mohamed et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline

(2012) Donald R. Royall et al.   Alzheimers & Dementia

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Aberrant phosphorylation in the pathogenesis of Alzheimer's disease

(2011) Sul-Hee Chung   BMB Reports

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

The Role of Neuroimmunomodulation in Alzheimer's Disease

(2009) Ricardo B. Maccioni et al.   Annals of the New York Academy of Sciences

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation

(2008) Pat Monaghan et al.   ECOLOGY LETTERS

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Genetic predisposition to inflammation: a new risk factor of Alzheimer’s disease

(2008) Ying Wan et al.   Neuroscience Bulletin

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

(2007) Leonel E. Rojo et al.   ARCHIVES OF MEDICAL RESEARCH