Review
Biochemistry & Molecular Biology
Antonios Lazaridis, Eleni Gavriilaki, Stella Douma, Eugenia Gkaliagkousi
Summary: Essential hypertension is a highly heterogeneous disease with a complex etiology, where subclinical inflammation and abnormal activation of TLR signaling play crucial roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Sara Francisco, Alicia Arranz, Javier Merino, Carmen Punzon, Rosario Perona, Manuel Fresno
Summary: The study found that TLR2 ligands activate MAPKs p38 and ERK earlier in macrophages, leading to higher levels of IL-10/IL-12 and IL-10/TNF-alpha ratios compared to TLR4 ligand LPS. Early TLR2-mediated p38 induction contributes to high IL-10 production, likely suppressing host Th1 response against certain pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sara Francisco, Jean-Marc Billod, Javier Merino, Carmen Punzon, Alicia Gallego, Alicia Arranz, Sonsoles Martin-Santamaria, Manuel Fresno
Summary: This study reveals that Ochrobactrum intermedium LPS can activate both TLR4 and TLR2, indicating the occurrence of TLR4/TLR2 heterodimerization, and the core saccharide plays an important role in this interaction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pedro Paulo Carneiro, Andreza S. Dorea, Walker N. Oliveira, Luiz Henrique Guimaraes, Claudia Brodskyn, Edgar M. Carvalho, Olivia Bacellar
Summary: Research has shown that the use of TLR2 and TLR4 antagonists can reduce the number of infected cells and internalized parasites in monocytes of CL patients, as well as decrease oxidative burst, IL-1 beta, TNF, and CXCL9 production. Additionally, TNF production in cells from CL lesions also decreased after neutralization of TLR2 and TLR4.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Mahsa Jalili, Azita Hekmatdoost
Summary: Ω-3 long-chain fatty acids play a crucial role in regulating inflammation and the immune system, especially in pathogen recognition and downstream signaling pathways. They may exert anti-inflammatory effects by influencing lipid rafts, modulating cytokines, and receptors, among other pathways.
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Virology
Caroline Fernandes-Santos, Elzinandes Leal de Azeredo
Summary: Dengue is a mosquito-borne viral disease caused by the dengue virus, with a wide range of clinical manifestations. In the innate antiviral response, Toll-like receptors (TLRs) play a critical role in pathogen recognition and the production of inflammatory cytokines and interferons essential for preventing viral replication.
Review
Immunology
Ryma Haroun, Sahar Naasri, Ayman J. Oweida
Summary: TLRs are essential for immune responses and can mediate inflammation by recognizing molecular patterns in pathogens and damaged cells. TLR ligands have gained attention in cancer research, especially in combination with cancer treatments like immunotherapy, chemotherapy, and radiotherapy (RT). However, the role of TLRs in cancer, particularly in response to radiation, is still poorly understood. This review examines how TLR signaling affects tumor response to RT and proposes a framework for TLR-based therapies with RT.
Article
Chemistry, Organic
Rachid Naitaleb, Agnes Denys, Fabrice Allain, Jerome Ausseil, Sylvestre Toumieux, Jose Kovensky
Summary: The study designed and synthesized sulfated compounds capable of crossing the blood-brain barrier, which were tested on HEK-TLR4 cells, demonstrating the potential of small oligosaccharides to modulate TLR4 activity with the 6-sulfate groups playing a key role in triggering TLR4 signalization.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Sui-Ling Liao, Man-Chin Hua, Ming-Han Tsai, Kuan-Wen Su, Chi Lin, Tsung-Chieh Yao, Li-Chen Chen, Kuo-Wei Yeh, Jing-Long Huang, Shen-Hao Lai
Summary: This study investigates the association between zinc status and immune homeostasis, as well as infectious outcome. The findings suggest that higher serum zinc is associated with a decreased risk of pneumonia and enterocolitis in well-nourished children.
Article
Medicine, Research & Experimental
Elsy Janeth Ramos-Gonzalez, Yadira Bastian, Julio Enrique Castaneda-Delgado, Martin Zapata-Zuniga, Mariela Gomez-Moreno, Jose Dionisio Castillo-Ortiz, Cesar Ramos-Remus, Jose Antonio Enciso-Moreno
Summary: The study found that the expression levels of TLR7 and TLR9 are elevated in the early stage of rheumatoid arthritis (RA), and may be associated with the production of autoantibodies, suggesting a role of TLR7 in the development of autoantibodies.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Immunology
Andres F. Londono, Diana G. G. Scorpio, J. Stephen Dumler
Summary: Rickettsial agents are diverse alpha-proteobacteria that can cause human diseases. They are mainly transmitted by arthropod vectors and have evolved various mechanisms to evade the host innate immune responses. This review focuses on the mechanisms used by two common rickettsial agents, Rickettsia species and Anaplasma phagocytophilum, to survive within and propagate from host cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Germana Lentini, Giuseppe Valerio De Gaetano, Agata Fama, Roberta Galbo, Francesco Coppolino, Giuseppe Mancuso, Giuseppe Teti, Concetta Beninati
Summary: The mechanisms of neutrophil response to live and dead organisms are unknown. It has been discovered that neutrophils produce significantly higher levels of the Cxcl2 chemokine in response to live bacteria compared to killed bacteria or isolated bacterial components. This response requires three signals, with two of them being provided by signal peptides released by live bacteria.
Article
Immunology
Cristina Cappelletti, Raffaella Brugnoni, Silvia Bonanno, Francesca Andreetta, Franco Salerno, Eleonora Canioni, Gaetano Nicola Alfio Vattemi, Paola Tonin, Renato Mantegazza, Lorenzo Maggi
Summary: This study aimed to investigate whether the immune system could serve as a source of potential biomarkers for stratifying immune-mediated necrotizing myopathies (IMNMs) subtypes. The results showed a significant preponderance of M1 macrophages in muscle samples of both SRP+ and HMGCR(+) IMNM patients. Furthermore, TLR4 and IL-7 were identified as potential immune biomarkers for differentiating between SRP+ and HMGCR+ patients.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Clinical Neurology
Luca Soraci, Maria Elsa Gambuzza, Leonardo Biscetti, Pasqualina Lagana, Carmela Lo Russo, Annamaria Buda, Giada Barresi, Andrea Corsonello, Fabrizia Lattanzio, Giuseppe Lorello, Gianfranco Filippelli, Silvia Marino
Summary: Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non-motor disturbances, which are thought to be caused by neuroinflammation, oxidative stress, and the presence of alpha-synuclein (alpha-syn) aggregates. Aging of the immune system and immune dysfunction may contribute to neuroinflammation leading to PD onset and progression, with abnormal alpha-syn aggregation activating the NLRP3 inflammasome within microglial cells through toll-like receptors (TLRs). This review focuses on the TLR/NLRP3/Cas-1 pathway in PD-related immune dysfunction and explores potential therapeutic options for counteracting neuroinflammation and immune dysfunction since the early stages of the disease.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dmitry V. Chistyakov, Gleb E. Gavrish, Sergei V. Goriainov, Viktor V. Chistyakov, Alina A. Astakhova, Nadezda V. Azbukina, Marina G. Sergeeva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Dmitry Chistyakov, Gleb Sergeev
Article
Biochemistry & Molecular Biology
Nadezhda Azbukina, Alexander Lopachev, Dmitry Chistyakov, Sergei Goriainov, Alina A. Astakhova, Vsevolod V. Poleshuk, Rogneda B. Kazanskaya, Tatiana N. Fedorova, Marina G. Sergeeva
Article
Biochemistry & Molecular Biology
Dmitry Chistyakov, Olga S. Gancharova, Viktoriia E. Baksheeva, Veronika V. Tiulina, Sergei Goriainov, Nadezhda Azbukina, Marina S. Tsarkova, Andrey A. Zamyatnin, Pavel P. Philippov, Marina G. Sergeeva, Ivan I. Senin, Evgeni Yu Zernii
Article
Biochemistry & Molecular Biology
Dmitry V. Chistyakov, Alina A. Astakhova, Sergei V. Goriainov, Marina G. Sergeeva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Dmitry V. Chistyakov, Sergei V. Goriainov, Alina A. Astakhova, Marina G. Sergeeva
Summary: Our study revealed a shift towards pro-inflammatory states in astrocytes cultivated in high glucose conditions, showing an imbalance in the release of inflammatory cytokine IL-6 and oxylipins. This suggests a potential new target for treating brain impairment associated with hyperglycemia by regulating COX-mediated oxylipin synthesis in astrocytes.
Article
Biochemistry & Molecular Biology
Mariia V. Guryleva, Dmitry V. Chistyakov, Alexander V. Lopachev, Sergei V. Goriainov, Alina A. Astakhova, Yulia A. Timoshina, Anastasiya V. Khutorova, Tatiana N. Fedorova, Marina G. Sergeeva
Summary: Reactive astrocytes may influence neurotoxicity and neuroprotection through oxylipins, suggesting that regulating oxylipin profiles could be a potential method for controlling neurotoxicity in inflammatory processes.
Article
Biology
Nadezhda V. Azbukina, Dmitry V. Chistyakov, Sergei V. Goriainov, Vladislav I. Kotelin, Elena V. Fedoseeva, Sergey Yu. Petrov, Marina G. Sergeeva, Elena N. Iomdina, Evgeni Yu. Zernii
Summary: The analysis of eye liquids from a cohort of primary open-angle glaucoma patients identified signaling lipids that suggest a role of arachidonic acid/platelet-activating factor (PAF)-dependent pathways and oxidative stress in the pathogenesis of the disease, providing novel targets for its diagnostics and treatment.
Article
Biology
Gleb E. Gavrish, Dmitry Chistyakov, Marina G. Sergeeva
Summary: ARGEOS is a user-friendly web tool designed to streamline the search and selection of transcriptome datasets from public databases, as well as to provide advanced analysis capabilities supporting research on cell polarization and other experimental inquiries.
Article
Biochemistry & Molecular Biology
Artem P. Gureev, Nadezda V. Andrianova, Irina B. Pevzner, Ljubava D. Zorova, Ekaterina V. Chernyshova, Irina S. Sadovnikova, Dmitry V. Chistyakov, Vasily A. Popkov, Dmitry S. Semenovich, Valentina A. Babenko, Denis N. Silachev, Dmitry B. Zorov, Egor Y. Plotnikov, Vasily N. Popov
Summary: This study found that in aging rats, mtDNA in the brain and kidneys was the most susceptible to age-related damage, while the liver, testis, and lungs were the least affected. Dietary restriction (DR) can prevent the accumulation of mtDNA damage in the cortex and reduce it in the lungs and testes.
Article
Biochemistry & Molecular Biology
A. M. Firsov, M. S. F. Franco, D. Chistyakov, S. Goriainov, M. G. Sergeeva, E. A. Kotova, M. A. Fomich, A. Bekish, O. L. Sharko, V. V. Shmanai, R. Itri, M. S. Baptista, Y. N. Antonenko, M. S. Shchepinov
Summary: Lipid peroxidation plays a crucial role in age-related neurological disorders and other conditions. Light irradiation can trigger lipid peroxidation, but introducing deuterated polyunsaturated fatty acids into membrane lipids can provide protection. Experimental results confirm the effectiveness of this method in protecting against lipid peroxidation and enhancing the protective effects of tocopherol.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Oncology
Dmitry Chistyakov, Mariia Guryleva, Elena S. Stepanova, Lyubov M. Makarenkova, Elena Ptitsyna, Sergei Goriainov, Arina Nikolskaya, Alina A. Astakhova, Anna S. Klimenko, Olga A. Bezborodova, Elena A. Rasskazova, Olga G. Potanina, Rimma A. Abramovich, Elena R. Nemtsova, Marina G. Sergeeva
Summary: This study investigates the alterations in oxylipin metabolism in breast cancer patients and identifies 18 differentially expressed oxylipins in the blood plasma of breast cancer patients at different stages. These oxylipin profiles could be used to evaluate the early stages of breast cancer.
Article
Biochemistry & Molecular Biology
Viktoriia E. Baksheeva, Veronika V. Tiulina, Elena N. Iomdina, Sergey Yu. Petrov, Olga M. Filippova, Nina Yu. Kushnarevich, Elena A. Suleiman, Remi Eyraud, Francois Devred, Marina V. Serebryakova, Natalia G. Shebardina, Dmitry V. Chistyakov, Ivan I. Senin, Vladimir A. Mitkevich, Philipp O. Tsvetkov, Evgeni Yu. Zernii
Summary: Primary open-angle glaucoma (POAG) is a common neurodegenerative disorder that causes blindness and is characterized by optic nerve and retinal ganglion cell damage. Early detection and treatment of the disease are crucial, but difficult due to its asymptomatic nature and lack of objective diagnostic approaches. Recent studies have shown that glaucoma involves complex metabolomic and proteomic changes in eye liquids, including tear fluid. However, the analysis of tear fluid is technically challenging and not suitable for clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dmitry Chistyakov, Arina Nikolskaya, Sergei Goriainov, Alina A. Astakhova, Marina G. Sergeeva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
D. Chistyakov, N. Azbukina, A. A. Astakhova, S. Goriainov, V. V. Chistyakov, V. V. Tiulina, O. S. Gancharova, V. E. Baksheeva, A. A. Zamyatnin, P. P. Philippov, M. G. Sergeeva, I. I. Senin, E. Yu Zernii
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2020)