MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer

(2020) Gita A. Pathak et al.   Alzheimers & Dementia

Effect of pH on the structure and function of pyruvate dehydrogenase kinase 3: Combined spectroscopic and MD simulation studies

(2020) Saleha Anwar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer

(2020) Taj Mohammad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies

(2020) Taj Mohammad et al.   MOLECULES

Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX

(2020) Babita Aneja et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Probing the Inhibition of Microtubule Affinity Regulating Kinase 4 by N-Substituted Acridones

(2019) Maria Voura et al.   Scientific Reports

Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer’s drug Donepezil with human transferrin: Implications of Alzheimer’s drug

(2019) Anas Shamsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Characterization of Microtubule Affinity-Regulating Kinase4 from Sus scrofa and Promotion of Lipogenesis in Primary Porcine Placental Trophoblasts

(2019) Liang Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of α-Mangostin as a Potential Inhibitor of Microtubule Affinity Regulating Kinase 4

(2019) Parvez Khan et al.   JOURNAL OF NATURAL PRODUCTS

Investigation of inhibitory potential of quercetin to the pyruvate dehydrogenase kinase 3: Towards implications in anticancer therapy

(2019) Rashmi Dahiya et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer’s disease

(2019) Ahmad Abu Turab Naqvi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

(2019) Eric Y. Hayden et al.   Acta Neuropathologica Communications

Kinase Inhibitors and Ovarian Cancer

(2019) Katopodis et al.   Cancers

Evaluation of ellagic acid as an inhibitor of sphingosine kinase 1: A targeted approach towards anticancer therapy

(2019) Preeti Gupta et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of High-Affinity Inhibitors of Cyclin-Dependent Kinase 2 Towards Anticancer Therapy

(2019) Taj Mohammad et al.   MOLECULES

Functional implications of pH-induced conformational changes in the Sphingosine kinase 1

(2019) Preeti Gupta et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Evaluation of binding and inhibition mechanism of dietary phytochemicals with sphingosine kinase 1: Towards targeted anticancer therapy

(2019) Preeti Gupta et al.   Scientific Reports

Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression

(2018) Farha Naz et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)

(2018) Taj Mohammad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Investigating the interaction of anticancer drug temsirolimus with human transferrin: Molecular docking and spectroscopic approach

(2018) Anas Shamsi et al.   JOURNAL OF MOLECULAR RECOGNITION

Synthesis, molecular docking and inhibition studies of novel 3-N-aryl substituted-2-heteroarylchromones targeting microtubule affinity regulating kinase 4 inhibitors

(2018) Iram Parveen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

High throughput screening, docking and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV

(2018) Anam Beg et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Thienopyrimidine–Chalcone Hybrid Molecules Inhibit Fas-Activated Serine/Threonine Kinase: An Approach To Ameliorate Antiproliferation in Human Breast Cancer Cells

(2018) Nashrah Sharif Khan et al.   MOLECULAR PHARMACEUTICS

Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis

(2018) Babita Aneja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Probing the interaction of anticancer drug temsirolimus with human serum albumin: molecular docking and spectroscopic insight

(2017) Anas Shamsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein. Spectroscopic and molecular docking approach

(2017) Mohammad Rehan Ajmal et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Elucidation of Dietary Polyphenolics as Potential Inhibitor of Microtubule Affinity Regulating Kinase 4: In silico and In vitro Studies

(2017) Parvez Khan et al.   Scientific Reports

miR‐515‐5p controls cancer cell migration through MARK4 regulation

(2016) Olivier E Pardo et al.   EMBO REPORTS

Ubiquitin-associated domain of MARK4 provides stability at physiological pH

(2016) Farha Naz et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Evaluation of human microtubule affinity-regulating kinase 4 inhibitors: fluorescence binding studies, enzyme, and cell assays

(2016) Farha Naz et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment

(2016) Wenchao Sun et al.   Scientific Reports

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor

(2016) John S. Sack et al.   Acta Crystallographica Section F-Structural Biology Communications

Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes

(2016) Zhenjiang Liu et al.   Scientific Reports

Editorial (Thematic Issue: Recent Advances in the Structure-Based Drug Design and Discovery)

(2015) Imtaiyaz Hassan   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Curcumin specifically binds to the human calcium–calmodulin-dependent protein kinase IV: fluorescence and molecular dynamics simulation studies

(2015) Nasimul Hoda et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Designing New Kinase Inhibitor Derivatives as Therapeutics Against Common Complex Diseases: Structural Basis of Microtubule Affinity-Regulating Kinase 4 (MARK4) Inhibition

(2015) Farha Naz et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Cloning, Expression, Purification and Refolding of Microtubule Affinity-Regulating Kinase 4 Expressed in Escherichia coli

(2014) Farha Naz et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Luminol-Based Chemiluminescent Signals: Clinical and Non-clinical Application and Future Uses

(2014) Parvez Khan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimer’s Disease

(2014) Maria Rodrigues Simoes et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The structural analysis of MARK4 and the exploration of specific inhibitors for the MARK family: a computational approach to obstruct the role of MARK4 in prostate cancer progression

(2014) Pranitha Jenardhanan et al.   Molecular BioSystems

Insight into the Binding Mechanism of Imipenem to Human Serum Albumin by Spectroscopic and Computational Approaches

(2014) Md Tabish Rehman et al.   MOLECULAR PHARMACEUTICS

Microtubule Affinity-Regulating Kinase 4: Structure, Function, and Regulation

(2013) Farha Naz et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Interaction of anthocyanins with human serum albumin: Influence of pH and chemical structure on binding

(2013) Yana Cahyana et al.   FOOD CHEMISTRY

A Comprehensive Insight into Binding of Hippuric Acid to Human Serum Albumin: A Study to Uncover Its Impaired Elimination through Hemodialysis

(2013) Nida Zaidi et al.   PLoS One

Microtubule-associated Protein/Microtubule Affinity-regulating Kinase 4 (MARK4) Is a Negative Regulator of the Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2012) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Study of Interaction of Silver Nanoparticles with Bovine Serum Albumin Using Fluorescence Spectroscopy

(2011) Jessy Mariam et al.   JOURNAL OF FLUORESCENCE

Fluorescence quenching and ligand binding: A critical discussion of a popular methodology

(2011) Marco van de Weert et al.   JOURNAL OF MOLECULAR STRUCTURE

Exploring the Mechanism of Fluorescence Quenching in Proteins Induced by Tetracycline

(2011) Uttam Anand et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Phenotypic Characterization of the Binding of Tetracycline to Human Serum Albumin

(2010) Zhenxing Chi et al.   BIOMACROMOLECULES

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease

(2008) Barnabas Wilson et al.   BRAIN RESEARCH

Interaction of mitoxantrone with human serum albumin: Spectroscopic and molecular modeling studies

(2008) Shahper N. Khan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES