Chronic Cardiotoxicity Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)

HUMAN iPSC ENGINEERED CARDIAC TISSUE PLATFORM FAITHFULLY MODELS IMPORTANT CARDIAC PHYSIOLOGY

(2021) Willem J. de Lange et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes

(2021) Orlando Chirikian et al.   Scientific Reports

Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC-CMs)

(2021) William P. Bozza et al.   AAPS Journal

Human Pluripotent Stem Cells for Modeling of Anticancer Therapy-Induced Cardiotoxicity and Cardioprotective Drug Discovery

(2021) Wendy Keung et al.   Frontiers in Pharmacology

Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

(2021) Magali Seguret et al.   Biomedicines

Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering

(2021) Eric K. N. Gähwiler et al.   Frontiers in Cell and Developmental Biology

Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes

(2021) Federica Lamberto et al.   Genes

Acute effects of cardiac contractility modulation on human induced pluripotent stem cell–derived cardiomyocytes

(2021) Tromondae K. Feaster et al.   Physiological Reports

The Emergence of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform to Model Arrhythmogenic Diseases

(2020) Marc Pourrier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

(2020) Elaheh Karbassi et al.   Nature Reviews Cardiology

A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential

(2020) Jessica A Palmer et al.   TOXICOLOGICAL SCIENCES

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

(2020) S. Tuuli Karhu et al.   ARCHIVES OF TOXICOLOGY

Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D Cultures

(2020) Claudia Sacchetto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electronic cigarette extract induced toxic effect in iPS-derived cardiomyocytes

(2020) Hesham Basma et al.   BMC Cardiovascular Disorders

Circulating high-sensitivity troponin T and microRNAs as markers of myocardial damage during childhood leukaemia treatment

(2020) Yiu-fai Cheung et al.   PEDIATRIC RESEARCH

Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes

(2020) Peng Wu et al.   BIOSCIENCE REPORTS

Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes

(2020) Steffen Pabel et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane (DDT)- and Dichlorodiphenyldichloroethylene (DDE)-Mediated Cardiotoxicity

(2020) Kim M Truong et al.   TOXICOLOGICAL SCIENCES

Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development

(2019) Hongchao Guo et al.   Stem Cell Reports

Assessment of proarrhythmic potential of drugs in optogenetically paced induced pluripotent stem cell-derived cardiomyocytes

(2019) Dakshesh Patel et al.   TOXICOLOGICAL SCIENCES

Cardiac Toxicity from Ethanol Exposure in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2019) Antonio Rampoldi et al.   TOXICOLOGICAL SCIENCES

Anthracycline Cardiotoxicity

(2019) Anna Narezkina et al.   Circulation-Heart Failure

MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo

(2019) Lorna R. Fiedler et al.   Cell Stem Cell

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

(2019) Idit Goldfracht et al.   Acta Biomaterialia

An Overview of Cancer Drugs Approved by the US Food and Drug Administration Based on the Surrogate End Point of Response Rate

(2019) Emerson Y. Chen et al.   JAMA Internal Medicine

Clinical trial in a dish: personalized stem cell derived cardiomyocyte assay compared to clinical trial results for two QT prolonging drugs

(2019) Ksenia Blinova et al.   CTS-Clinical and Translational Science

Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association

(2019) Gary Gintant et al.   CIRCULATION RESEARCH

Continued exposure of anti-cancer drugs to human iPS cell-derived cardiomyocytes can unmask their cardiotoxic effects

(2019) Kazuho Sakamoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

CRISPR/Cas9 gene-editing strategies in cardiovascular cells

(2019) Eva Vermersch et al.   CARDIOVASCULAR RESEARCH

Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity

(2019) Kuo-Chan Weng et al.   TISSUE ENGINEERING PART C-METHODS

Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes

(2019) Wei Cheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems

(2018) Tarek Magdy et al.   Annual Review of Pharmacology and Toxicology

Comprehensive review of cardiovascular toxicity of drugs and related agents

(2018) Přemysl Mladěnka et al.   MEDICINAL RESEARCH REVIEWS

miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway

(2018) Marta Diez-Cuñado et al.   Cell Reports

Modeling Human Cardiac Hypertrophy in Stem Cell-Derived Cardiomyocytes

(2018) Ekaterina Ovchinnikova et al.   Stem Cell Reports

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

(2018) Ksenia Blinova et al.   Cell Reports

Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity

(2018) Arun Sharma et al.   Nature Protocols

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells

(2017) Arun Sharma et al.   Science Translational Medicine

Impact of Electronic Cigarettes on the Cardiovascular System

(2017) Hanan Qasim et al.   Journal of the American Heart Association

hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen

(2017) André Monteiro da Rocha et al.   Scientific Reports

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

(2016) Marcela K. Preininger et al.   Disease Models & Mechanisms

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of Batch Variations in Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes from 2 Major Suppliers

(2016) Jianhua Huo et al.   TOXICOLOGICAL SCIENCES

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

(2016) Ksenia Blinova et al.   TOXICOLOGICAL SCIENCES

Cardiovascular toxicity of nicotine: Implications for electronic cigarette use

(2016) Neal L. Benowitz et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) Ivan Kopljar et al.   Stem Cells Translational Medicine

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

(2015) Umesh Chaudhari et al.   ARCHIVES OF TOXICOLOGY

Cardiac complications in childhood cancer survivors treated with anthracyclines

(2015) Vivian I. Franco et al.   CARDIOLOGY IN THE YOUNG

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

(2015) I. Karakikes et al.   CIRCULATION RESEARCH

Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells

(2015) Gustav Holmgren et al.   TOXICOLOGY

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types

(2015) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiac Development in Zebrafish and Human Embryonic Stem Cells Is Inhibited by Exposure to Tobacco Cigarettes and E-Cigarettes

(2015) Nathan J. Palpant et al.   PLoS One

An analysis of FDA-approved drugs for oncology

(2014) Michael S. Kinch   DRUG DISCOVERY TODAY

Epidemiology of Heart Failure

(2013) Véronique L. Roger   CIRCULATION RESEARCH

Perfluorooctane sulfonate (PFOS) induced embryotoxicity and disruption of cardiogenesis

(2013) Wei Cheng et al.   TOXICOLOGY IN VITRO

Pluripotent Stem Cell Models of Human Heart Disease

(2013) A. Moretti et al.   Cold Spring Harbor Perspectives in Medicine

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy

(2012) N. Sun et al.   Science Translational Medicine

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

(2012) Maaike Hoekstra et al.   Frontiers in Physiology

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells

(2009) Igal Germanguz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

(2009) Adriana Albini et al.   JNCI-Journal of the National Cancer Institute

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL