Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity

Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems

(2018) Tarek Magdy et al.   Annual Review of Pharmacology and Toxicology

Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells

(2018) Ning Ma et al.   CIRCULATION

Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?

(2018) Jonathan P Stack et al.   EUROPEAN HEART JOURNAL

Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant

(2018) Priyanka Garg et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

(2018) Daniel Millard et al.   TOXICOLOGICAL SCIENCES

Cardiovascular Complications of Cancer Therapy

(2017) Hui-Ming Chang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiovascular Complications of Cancer Therapy

(2017) Hui-Ming Chang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chemical-defined and albumin-free generation of human atrial and ventricular myocytes from human pluripotent stem cells

(2017) Fei Pei et al.   Stem Cell Research

A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

(2017) Hiroyuki Ando et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes

(2017) Wesley L. McKeithan et al.   Frontiers in Physiology

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods

(2017) Jared M. Churko et al.   Nature Biomedical Engineering

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development

(2016) Juan C. del Álamo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell–Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome

(2016) Ping Liang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy

(2016) Kazuki Kodo et al.   NATURE CELL BIOLOGY

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

(2016) Ksenia Blinova et al.   TOXICOLOGICAL SCIENCES

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

(2016) Thomas Colatsky et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Genetic and Epigenetic Regulation of Human Cardiac Reprogramming and Differentiation in Regenerative Medicine

(2015) Paul W. Burridge et al.   Annual Review of Genetics

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

(2015) Haodi Wu et al.   Cell Stem Cell

Tyrosine Kinase Inhibitor–Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia

(2015) Javid J. Moslehi et al.   JOURNAL OF CLINICAL ONCOLOGY

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling

(2015) Indroneal Banerjee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chemically defined, albumin-free human cardiomyocyte generation

(2015) Xiaojun Lian et al.   NATURE METHODS

Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?

(2015) Christiaan C. Veerman et al.   STEM CELLS AND DEVELOPMENT

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3–Induced Myocarditis and Antiviral Drug Screening Platform

(2014) Arun Sharma et al.   CIRCULATION RESEARCH

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

(2013) Feng Lan et al.   Cell Stem Cell

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery

(2013) Mark Mercola et al.   CIRCULATION RESEARCH

Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity

(2013) Nicola Ferri et al.   PHARMACOLOGY & THERAPEUTICS

Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening

(2013) Arun Sharma et al.   Stem Cell Research & Therapy

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Long-Duration Time-Resolved PIV to Study Unsteady Aerodynamics

(2010) Zachary J. Taylor et al.   IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of Myocyte Cytotoxicity Induced by the Multikinase Inhibitor Sorafenib

(2009) Brian B. Hasinoff et al.   Cardiovascular Toxicology

Cardiotoxic drugs: clinical monitoring and decision making

(2008) A. H Wu   HEART