A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

The Direct Actions of Flecainide on the Human Cardiac Ryanodine Receptor: Keeping Open the Debate on the Mechanism of Action of Local Anesthetics in CPVT

(2015) G. L. Smith et al.   CIRCULATION RESEARCH

The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2

(2015) M. L. Bannister et al.   CIRCULATION RESEARCH

Catecholaminergic Polymorphic Ventricular Tachycardia in Children

(2015) Thomas M. Roston et al.   Circulation-Arrhythmia and Electrophysiology

Induced Pluripotent Stem Cells

(2015) Kitchener D. Wilson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

(2015) Yan-Ting Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models

(2015) Kirsi Penttinen et al.   PLoS One

Engineering Adolescence

(2014) Xiulan Yang et al.   CIRCULATION RESEARCH

Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study

(2014) Yuji Nakamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Systemic Evaluation of Cardiac Differentiation from mRNA Reprogrammed Human Induced Pluripotent Stem Cells

(2014) Ashish Mehta et al.   PLoS One

Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current

(2013) Markus B. Sikkel et al.   CARDIOVASCULAR RESEARCH

Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects

(2013) X.-H. Zhang et al.   CELL CALCIUM

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2013) Daniel Sinnecker et al.   CIRCULATION RESEARCH

Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia

(2013) L. Brunello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

(2013) E Di Pasquale et al.   Cell Death & Disease

Mutations in Cytoplasmic Loops of the KCNQ1 Channel and the Risk of Life-Threatening Events

(2012) Alon Barsheshet et al.   CIRCULATION

Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells

(2012) Ilanit Itzhaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Reveals Early and Delayed Afterdepolarizations

(2012) Kirsi Kujala et al.   PLoS One

Alternans and Arrhythmias

(2011) James N. Weiss et al.   CIRCULATION RESEARCH

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

(2011) Christian B. Jung et al.   EMBO Molecular Medicine

Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin

(2011) Eleonora Savio Galimberti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Christian van der Werf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction

(2010) N. Lowri Thomas et al.   FEBS LETTERS

Rabbit, a relevant model for the study of cardiac β3-adrenoceptors

(2009) Leslie Audigane et al.   EXPERIMENTAL PHYSIOLOGY

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols