Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types

(2015) Kimberly R. Doherty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Suppression of Rad leads to arrhythmogenesis via PKA-mediated phosphorylation of ryanodine receptor activity in the heart

(2014) Hiroyuki Yamakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction

(2014) Dong Fan et al.   CARDIOVASCULAR RESEARCH

Connexin40 abnormalities and atrial fibrillation in the human heart

(2014) Joanna Gemel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Human Stem Cells for Modeling Heart Disease and for Drug Discovery

(2014) E. Matsa et al.   Science Translational Medicine

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca 2+ Regulation by Distinct Mechanisms

(2014) Guo Yin et al.   Journal of the American Heart Association

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

(2014) Stefan Dhein et al.   Frontiers in Physiology

A phase I dose-escalation study of intravenous panobinostat in patients with lymphoma and solid tumors

(2013) Sunil Sharma et al.   INVESTIGATIONAL NEW DRUGS

A phase I study of vorinostat in combination with bortezomib in patients with advanced malignancies

(2013) William R. Schelman et al.   INVESTIGATIONAL NEW DRUGS

KCNJ2mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia

(2013) Makarand Deo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model

(2013) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Histone deacetylase inhibition reduces cardiac connexin43 expression and gap junction communication

(2013) Qin Xu et al.   Frontiers in Pharmacology

Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed

(2012) Berkley E Gryder et al.   Future Medicinal Chemistry

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

Mitochondria–cytoskeleton interaction: Distribution of β-tubulins in cardiomyocytes and HL-1 cells

(2011) Rita Guzun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The effect of food on the bioavailability of panobinostat, an orally active pan-histone deacetylase inhibitor, in patients with advanced cancer

(2011) Geoffrey I. Shapiro et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents

(2011) T. Hattori et al.   CARDIOVASCULAR RESEARCH

G i -Biased β 2 AR Signaling Links GRK2 Upregulation to Heart Failure

(2011) Weizhong Zhu et al.   CIRCULATION RESEARCH

Molecular Genetic and Functional Characterization Implicate Muscle-Restricted Coiled-Coil Gene ( MURC ) as a Causal Gene for Familial Dilated Cardiomyopathy

(2011) Gabriela Rodriguez et al.   Circulation-Cardiovascular Genetics

Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

(2011) Michael D. Shultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

N -lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

(2011) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2010) Pontus Boström et al.   CELL

Short QT Syndrome: From Bench to Bedside

(2010) Chinmay Patel et al.   Circulation-Arrhythmia and Electrophysiology

Regulation of gap-junction protein connexin 43 by β-adrenergic receptor stimulation in rat cardiomyocytes

(2009) Yi Xia et al.   ACTA PHARMACOLOGICA SINICA

Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

(2009) David Hassel et al.   NATURE MEDICINE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

GADD45B inhibits MKK7-induced cardiac hypertrophy and the polymorphisms of GADD45B is associated with inter-ventricular septum hypertrophy

(2008) Jianwei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

(2008) H R Lu et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

(2008) L. Gore et al.   CLINICAL CANCER RESEARCH

Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors

(2008) J. S. de Bono et al.   CLINICAL CANCER RESEARCH

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DUSP6 (MKP3) Null Mice Show Enhanced ERK1/2 Phosphorylation at Baseline and Increased Myocyte Proliferation in the Heart Affecting Disease Susceptibility

(2008) Marjorie Maillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinically Relevant QTc Prolongation Is Not Associated With Current Dose Schedules of LBH589 (panobinostat)

(2008) Lei Zhang et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program

(2008) Esta Bovill et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS