Roles and Regulation of BCL-xL in Hematological Malignancies

Susceptibility of multiple myeloma to B-cell lymphoma 2 family inhibitors

(2021) Manon Lernoux et al.   BIOCHEMICAL PHARMACOLOGY

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

(2020) Consuelo Borrás et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Krüppel-Like Factor 4 (KLF4) expression through the transcription factor Yin-Yang 1 (YY1) in non-Hodgkin B-cell lymphoma

(2019) Mario Morales-Martinez et al.   Oncotarget

Expanding the repertoire of miRNAs and miRNA-offset RNAs expressed in multiple myeloma by small RNA deep sequencing

(2019) Luca Agnelli et al.   Blood Cancer Journal

Blockade of miR-142-3p promotes anti-apoptotic and suppressive function by inducing KDM6A-mediated H3K27me3 demethylation in induced regulatory T cells

(2019) Ji Gao et al.   Cell Death & Disease

Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies

(2019) Fevzi F. Yalniz et al.   DRUGS

miR-155 as a novel clinical target for hematological malignancies

(2019) Lisa Witten et al.   CARCINOGENESIS

SIGNOR 2.0, the SIGnaling Network Open Resource 2.0: 2019 update

(2019) Luana Licata et al.   NUCLEIC ACIDS RESEARCH

Live Attenuated Salmonella enterica Expressing and Releasing Cell-Permeable Bax BH3 Peptide Through the MisL Autotransporter System Elicits Antitumor Activity in a Murine Xenograft Model of Human B Non-hodgkin's Lymphoma

(2019) Armando Alfredo Mateos-Chávez et al.   Frontiers in Immunology

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Venetoclax for the treatment of multiple myeloma

(2018) Iuliana Vaxman et al.   Expert Review of Hematology

Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

(2017) Chiara Gabellini et al.   INTERNATIONAL JOURNAL OF CANCER

BCL-XL overexpression promotes tumor progression-associated properties

(2017) Daniela Trisciuoglio et al.   Cell Death & Disease

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors

(2016) A. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models

(2016) E. A. Punnoose et al.   MOLECULAR CANCER THERAPEUTICS

The eukaryotic promoter database in its 30th year: focus on non-vertebrate organisms

(2016) René Dreos et al.   NUCLEIC ACIDS RESEARCH

Bcl-xL promotes metastasis independent of its anti-apoptotic activity

(2016) Soyoung Choi et al.   Nature Communications

Circulating microRNA expression profile in B-cell acute lymphoblastic leukemia

(2015) Claudia Maribel Luna-Aguirre et al.   Cancer Biomarkers

Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation

(2015) M. Rahmani et al.   HAEMATOLOGICA

miR-377-dependent BCL-xL regulation drives chemotherapeutic resistance in B-cell lymphoid malignancies

(2015) Sayer Al-harbi et al.   Molecular Cancer

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer

(2015) M K Farrugia et al.   Cell Death & Disease

Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation

(2015) M. Rahmani et al.   HAEMATOLOGICA

BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells

(2014) Mariarita Perri et al.   EXPERIMENTAL CELL RESEARCH

MicroRNAs in hematological malignancies

(2013) Charles H. Lawrie   BLOOD REVIEWS

MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1

(2013) Fang Ji et al.   BONE

An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

(2013) Z Zhang et al.   BRITISH JOURNAL OF CANCER

Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1  in a p53-Independent Manner

(2013) S. Wu et al.   CANCER RESEARCH

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

(2013) Jie Zou et al.   Journal of Hematology & Oncology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficient Generation of Integration-Free iPS Cells from Human Adult Peripheral Blood Using BCL-XL Together with Yamanaka Factors

(2013) Rui-Jun Su et al.   PLoS One

MicroRNA-7 Inhibits the Growth of Human Non-Small Cell Lung Cancer A549 Cells through Targeting BCL-2

(2012) Shudao Xiong et al.   International Journal of Biological Sciences

Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL

(2012) Marco A. Hernandez-Luna et al.   LEUKEMIA & LYMPHOMA

MicroRNA profiling: approaches and considerations

(2012) Colin C. Pritchard et al.   NATURE REVIEWS GENETICS

Contribution of either YY1 or BclXL-induced inhibition by the NO-donor DETANONOate in the reversal of drug resistance, both in vitro and in vivo. YY1 and BclXL are overexpressed in prostate cancer

(2012) Sara Huerta-Yepez et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R

(2012) J Gong et al.   ONCOGENE

Prognostic significance of Bcl-xL gene expression in human colorectal cancer

(2011) Yang Jin-Song et al.   ACTA HISTOCHEMICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis

(2011) Melisa A. Martínez-Paniagua et al.   CELL CYCLE

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

(2010) Scott Ackler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1

(2010) Dinesh S. Rao et al.   IMMUNITY

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

(2010) Satoshi Shimizu et al.   JOURNAL OF HEPATOLOGY

High-risk myeloma is associated with global elevation of miRNAs and overexpression ofEIF2C2/AGO2

(2010) Yiming Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: An integrated genomics approach reveals a wide gene dosage effect

(2009) Luca Agnelli et al.   GENES CHROMOSOMES & CANCER

BCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α

(2009) Ni Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of microRNA in human leukemia: a review

(2009) S Yendamuri et al.   LEUKEMIA

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Genetic Ablation of Bcl-x Attenuates Invasiveness without Affecting Apoptosis or Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Cancer

(2009) Jeffrey H. Hager et al.   PLoS One

Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling

(2008) M. S. Raab et al.   BLOOD

Deregulation of the Mitochondrial Apoptotic Machinery and Development of Molecular Targeted Drugs in Acute Myeloid Leukemia

(2008) G. Poeta et al.   CURRENT CANCER DRUG TARGETS

Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma

(2008) Chiara Gabellini et al.   JOURNAL OF NEUROCHEMISTRY

The oral protein-kinase Cβinhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines

(2008) Antonino Neri et al.   LEUKEMIA & LYMPHOMA

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

(2008) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

Stromal Gene Signatures in Large-B-Cell Lymphomas

(2008) G. Lenz et al.   NEW ENGLAND JOURNAL OF MEDICINE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY