BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

A Delicate Balance - The BCL-2 Family and its Role in Apoptosis, Oncogenesis, and Cancer Therapeutics

(2019) Tristan Knight et al.   BIOCHEMICAL PHARMACOLOGY

BCL-2 family isoforms in apoptosis and cancer

(2019) Chloe F. A. Warren et al.   Cell Death & Disease

The Structural Biology of Bcl-xL

(2019) Erinna F. Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL

(2019) Victor Vasquez-Montes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins

(2019) Tudor Moldoveanu et al.   Cold Spring Harbor Perspectives in Biology

Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation

(2018) Feng Ni et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

(2018) Ariele Viacava Follis et al.   Nature Chemical Biology

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells

(2018) Sylvia S. Gayle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins

(2017) Abdel Aouacheria et al.   NEUROCHEMISTRY INTERNATIONAL

Understanding Aging

(2017) Manuel Serrano   NEW ENGLAND JOURNAL OF MEDICINE

The long unstructured region of Bcl-xl modulates its structural dynamics

(2017) Prerna Priya et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging

(2016) Consuelo Borras et al.   Aging-US

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts

(2016) Prasamit Saurav Baruah et al.   PLoS One

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced Autophagy and Apoptosis via Interplay with Beclin 1

(2015) Jiong Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival

(2015) M. Veas-Perez de Tudela et al.   JOURNAL OF NEUROSCIENCE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy

(2014) Lisa M Lindqvist et al.   Autophagy

Regulating cell death at, on, and in membranes

(2014) Xiaoke Chi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL

(2014) Dominic P. Del Re et al.   MOLECULAR CELL

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

(2014) L. M. Lindqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many players in BCL-2 family affairs

(2014) Tudor Moldoveanu et al.   TRENDS IN BIOCHEMICAL SCIENCES

BCL2DB: database of BCL-2 family members and BH3-only proteins

(2014) V. Rech de Laval et al.   Database-The Journal of Biological Databases and Curation

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

(2013) Hongmei Li et al.   NATURE CELL BIOLOGY

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

(2013) Ariele Viacava Follis et al.   Nature Chemical Biology

Control of Cellular Bcl-xL Levels by Deamidation-Regulated Degradation

(2013) So Hee Dho et al.   PLOS BIOLOGY

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints

(2011) Jianfang Wang et al.   CELLULAR SIGNALLING

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

(2010) Maria Chiara Maiuri et al.   EMBO JOURNAL

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

(2010) Feifan Zhou et al.   FEBS Journal

Still embedded together binding to membranes regulates Bcl-2 protein interactions

(2010) B Leber et al.   ONCOGENE

Bcl-xLincreases mitochondrial fission, fusion, and biomass in neurons

(2009) Sarah B. Berman et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission and fusion dynamics: the long and short of it

(2008) S B Berman et al.   CELL DEATH AND DIFFERENTIATION

Senescence, Apoptosis or Autophagy?

(2008) José Miguel Vicencio et al.   GERONTOLOGY

Bcl-xLand UVRAG Cause a Monomer-Dimer Switch in Beclin1

(2008) Christian G. Noble et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Bcl-xL Inhibitor ABT-737 Reveals a Dual Role for Bcl-xL in Synaptic Transmission

(2007) John A. Hickman et al.   JOURNAL OF NEUROPHYSIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY