An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

S1, a Novel Pan-BH3 Mimetic, Induces Apoptosis in Mcl-1-Overexpressing Cells Through Bak

(2012) Ting Song et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737

(2011) S. Al-harbi et al.   BLOOD

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) Based Molecules as Potent, Dual Inhibitors of B-Cell Lymphoma 2 (Bcl-2) and Myeloid Cell Leukemia Sequence 1 (Mcl-1): Structure-Based Design and Structure−Activity Relationship Studies

(2011) Zhichao Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1

(2010) Zhichao Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Inclusion Complex of a Bcl-2 Inhibitor with Cyclodextrin: Characterization, Cellular Accumulation, and in Vivo Antitumor Activity

(2010) Zhichao Zhang et al.   MOLECULAR PHARMACEUTICS

Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia

(2009) R. W. Stam et al.   BLOOD

Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis

(2009) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

International Myeloma Working Group molecular classification of multiple myeloma: spotlight review

(2009) R Fonseca et al.   LEUKEMIA

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

(2008) M. Vogler et al.   BLOOD

BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells

(2008) P Pérez-Galán et al.   LEUKEMIA

BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

(2008) J. L. Mott et al.   MOLECULAR CANCER THERAPEUTICS

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY