Atopic Dermatitis: The Fate of the Fat

The molecular features of normal and atopic dermatitis skin in infants, children, adolescents and adults

(2021) Yael Renert-Yuval et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge of the Pathogenesis of Atopic Dermatitis: Sphingomyelin Deacylase, the Enzyme Involved in Its Ceramide Deficiency, Plays a Pivotal Role

(2021) Genji Imokawa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Real-world comorbidities of atopic dermatitis in the pediatric ambulatory population in the United States

(2021) Amy H. Huang et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

CD1a selectively captures endogenous cellular lipids that broadly block T cell response

(2021) Rachel N. Cotton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ceramides in Skin Health and Disease: An Update

(2021) Yoshikazu Uchida et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Eight novel susceptibility loci and putative causal variants in atopic dermatitis

(2021) Nao Tanaka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inborn errors of immunity manifesting as atopic disorders

(2021) Maryam Vaseghi-Shanjani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Subtypes of atopic dermatitis: From phenotype to endotype

(2021) Yoshiki Tokura et al.   ALLERGOLOGY INTERNATIONAL

Reframing racial and ethnic disparities in atopic dermatitis in Black and Latinx populations

(2021) Emily A. Croce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reconciling innate and acquired immunity in atopic dermatitis

(2020) Tetsuya Honda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu

(2020) Ruzica Jurakic Toncic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic factors involved in the pathophysiology of inflammatory skin diseases

(2020) Lena Möbus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review

(2020) Maria J Martin et al.   Genes

Cutaneous barrier dysfunction in allergic diseases

(2020) Donald Y.M. Leung et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Atopic dermatitis displays stable and dynamic skin transcriptome signatures

(2020) Lena Möbus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

First evidences of distinguishable bacterial and fungal dysbiosis in the skin of patients with Atopic Dermatitis or Netherton Syndrome

(2020) Verena Moosbrugger-Martinz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

(2020) Irini M. Dijkhoff et al.   Particle and Fibre Toxicology

Primary Prevention of Allergic Diseases: The Role of Early Exposure to Cow's Milk Formula

(2020) Carla Mastrorilli et al.   Frontiers in Pediatrics

Dual function of Langerhans cells in skin TSLP-promoted Tfh cell differentiation in mouse atopic dermatitis

(2020) Pierre Marschall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mild atopic dermatitis lacks systemic inflammation, and shows reduced non-lesional skin abnormalities

(2020) Helen He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association of serum lipid parameters with the SCORAD index and onset of atopic dermatitis in children

(2020) Ju Hee Kim et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Shaping of Dendritic Cell Function by the Metabolic Micro-Environment

(2020) Eline Constance Brombacher et al.   Frontiers in Endocrinology

Updating Phospholipase A2 Biology

(2020) Makoto Murakami et al.   Biomolecules

Topical Corticosteroids Normalize both Skin and Systemic Inflammatory Markers in Infant Atopic Dermatitis

(2020) M.A. McAleer et al.   BRITISH JOURNAL OF DERMATOLOGY

JAK1/2 inhibition impairs the development and function of inflammatory dendritic epidermal cells in atopic dermatitis.

(2020) Anna Sophie Klaeschen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia

(2020) Peng Sun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic dermatitis endotypes and implications for targeted therapeutics

(2019) Tali Czarnowicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IFN-γ Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model

(2019) Hiroyuki Kanoh et al.   Journal of Immunology Research

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype

(2019) Donald Y. M. Leung et al.   Science Translational Medicine

Eicosanoids in tissue repair

(2019) Julia Esser-von Bieren   IMMUNOLOGY AND CELL BIOLOGY

The role of Langerhans cells in pathologies of the skin

(2019) Aarthi Rajesh et al.   IMMUNOLOGY AND CELL BIOLOGY

Atopic dermatitis and the metabolic syndrome: a cross‐sectional study of 116 816 patients

(2019) G. Shalom et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis

(2019) Nilika Bhattacharya et al.   TRENDS IN MOLECULAR MEDICINE

3D-Organotypic Cultures to Unravel Molecular and Cellular Abnormalities in Atopic Dermatitis and Ichthyosis Vulgaris

(2019) Géraldine Leman et al.   Cells

Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents

(2019) Arnout Mieremet et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Peptides from allergenic lipocalins bind to Formyl-Peptide-Receptor 3 in human dendritic cells to mediate Th2 immunity.

(2019) Dominik Klaver et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond

(2019) Rui Liu et al.   Frontiers in Immunology

Body mass index and serum lipid profile: Association with atopic dermatitis in a paediatric population

(2019) Pedro Jesús Agón‐Banzo et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Filaggrin expression and processing deficiencies impair corneocyte surface texture and stiffness in mice

(2019) Jacob P. Thyssen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic dermatitis and metabolic syndrome: lifestyle or systemic inflammation?

(2019) C. Vestergaard   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The IL ‐13– OVOL 1– FLG axis in atopic dermatitis

(2019) Kazuhisa Furue et al.   IMMUNOLOGY

The Cornified Envelope-Bound Ceramide Fraction Is Altered in Patients with Atopic Dermatitis

(2019) Walter Boiten et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

(2019) Carolyn M Walsh et al.   eLife

Epidemiology of atopic dermatitis in adults: Results from an international survey

(2018) S. Barbarot et al.   ALLERGY

Immunologic, microbial, and epithelial interactions in atopic dermatitis

(2018) Patrick M. Brunner et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Early-onset pediatric atopic dermatitis is characterized by T H 2/T H 17/T H 22-centered inflammation and lipid alterations

(2018) Patrick M. Brunner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of the OVOL1–OVOL2 axis in normal and diseased human skin

(2018) Gaku Tsuji et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Enhanced Expression of Genes Related to Xenobiotic Metabolism in the Skin of Patients with Atopic Dermatitis but Not with Ichthyosis Vulgaris

(2018) Stefan Blunder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Effects of atopic dermatitis and gender on sebum lipid mediator and fatty acid profiles

(2018) Karan Agrawal et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2

(2018) A. Gaudin et al.   Scientific Reports

Clustering-based preprocessing method for lipidomic data analysis: application for the evolution of newborn skin surface lipids from birth until 6 months

(2018) Rime Michael-Jubeli et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Age-dependent transformation of skin biomechanical properties and micromorphology during infancy and childhood

(2018) Joachim W. Fluhr et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Uncovering the Mysteries of Langerhans Cells, Inflammatory Dendritic Epidermal Cells, and Monocyte-Derived Langerhans Cell-Like Cells in the Epidermis

(2018) Masayuki Otsuka et al.   Frontiers in Immunology

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients

(2018) Patrick M. Brunner et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Transcriptomic and lipidomic profiling of eicosanoid / docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients

(2018) Daniel Töröcsik et al.   EXPERIMENTAL DERMATOLOGY

The microbiome in patients with atopic dermatitis

(2018) Amy S. Paller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment

(2017) Emma Guttman-Yassky et al.   EXPERIMENTAL DERMATOLOGY

Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition

(2017) Mogbekeloluwa Danso et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Atopic Dermatitis and Comorbidities: Added Value of Comprehensive Dermatoepidemiology

(2017) Tamar Nijsten   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases

(2017) Marie Standl et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alterations in Epidermal Eicosanoid Metabolism Contribute to Inflammation and Impaired Late Differentiation in FLG- Mutated Atopic Dermatitis

(2017) Stefan Blunder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atopic dermatitis is associated with active and passive cigarette smoking in adolescents

(2017) So Young Kim et al.   PLoS One

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

(2017) Gaku Tsuji et al.   Cell Death & Disease

Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

(2017) Charles Caër et al.   Scientific Reports

The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins

(2017) Patrick M. Brunner et al.   Scientific Reports

Early-onset pediatric atopic dermatitis is T H 2 but also T H 17 polarized in skin

(2016) Hitokazu Esaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

(2016) Thomas Werfel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles

(2016) Lisa M. Connor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation

(2016) Romain A. Colas et al.   JOURNAL OF IMMUNOLOGY

Association of atopic dermatitis with smoking: A systematic review and meta-analysis

(2016) Robert Kantor et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Ambient humidity and the skin: the impact of air humidity in healthy and diseased states

(2016) N. Goad et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Atopic dermatitis

(2016) Stephan Weidinger et al.   LANCET

CD1a on Langerhans cells controls inflammatory skin disease

(2016) Ji Hyung Kim et al.   NATURE IMMUNOLOGY

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

(2016) Rachael Jarrett et al.   Science Translational Medicine

Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes

(2016) Le Cui et al.   Journal of Cosmetic Dermatology

Natural History of Food-Triggered Atopic Dermatitis and Development of Immediate Reactions in Children

(2016) Angela Chang et al.   Journal of Allergy and Clinical Immunology-In Practice

Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis

(2015) Lars Lind et al.   ATHEROSCLEROSIS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals

(2015) Sumithra Subramaniam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

(2015) Tetsuro Kobayashi et al.   IMMUNITY

Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

(2015) Maeve Kelleher et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets

(2015) Tali Czarnowicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bee venom processes human skin lipids for presentation by CD1a

(2015) Elvire A. Bourgeois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of sebaceous glands in inflammatory dermatoses

(2015) Vivian Y. Shi et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The effect of environmental humidity and temperature on skin barrier function and dermatitis

(2015) K.A. Engebretsen et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis

(2015) B. Wu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Meta-analysis identifies seven susceptibility loci involved in the atopic march

(2015) Ingo Marenholz et al.   Nature Communications

Development and organization of human stratum corneum after birth: electron microscopy isotropy score and immunocytochemical corneocyte labelling as epidermal maturation's markers in infancy

(2014) J.W. Fluhr et al.   BRITISH JOURNAL OF DERMATOLOGY

Reduced filaggrin expression is accompanied by increasedStaphylococcus aureuscolonization of epidermal skin models

(2014) V. van Drongelen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Two distinct leukotriene B4 receptors, BLT1 and BLT2

(2014) T. Yokomizo   JOURNAL OF BIOCHEMISTRY

Monounsaturated Fatty Acids Reduce the Barrier of Stratum Corneum Lipid Membranes by Enhancing the Formation of a Hexagonal Lateral Packing

(2014) Enamul H. Mojumdar et al.   LANGMUIR

Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability

(2014) Adrienne Müller et al.   NUCLEAR MEDICINE AND BIOLOGY

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

(2013) Jeroen van Smeden et al.   EXPERIMENTAL DERMATOLOGY

Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis

(2013) Nicolas Loiseau et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3D Skin Construct

(2013) Kateřina Vávrová et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα

(2012) Osamu Hanyu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

(2012) H. H. Kong et al.   GENOME RESEARCH

Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation

(2012) Michiko K. Oyoshi et al.   IMMUNITY

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

(2012) Sanja Kezic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

(2012) Saeko Nakajima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Atopic dermatitis results in intrinsic barrier and immune abnormalities: Implications for contact dermatitis

(2012) Julia K. Gittler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin–induced keratinocyte death

(2012) Anne M. Brauweiler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

(2012) Michelle Janssens et al.   JOURNAL OF LIPID RESEARCH

Eicosanoids in skin inflammation

(2012) Anna Nicolaou   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

(2011) Robert Gruber et al.   AMERICAN JOURNAL OF PATHOLOGY

Profiling and Characterizing Skin Ceramides Using Reversed-Phase Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry

(2011) Ruben t’Kindt et al.   ANALYTICAL CHEMISTRY

Expression of Epidermal CAMP Changes in Parallel with Permeability Barrier Status

(2011) Marina Rodriguez-Martin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

(2010) J. M. Jungersted et al.   ALLERGY

Atopic dermatitis: the role of Langerhans cells in disease pathogenesis

(2010) Sandrine Dubrac et al.   IMMUNOLOGY AND CELL BIOLOGY

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

(2010) Helen Miajlovic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD34+-derived Langerhans cell-like cells are different from epidermal Langerhans cells in their response to thymic stromal lymphopoietin

(2010) Van Anh Nguyen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Changes in the Ceramide Profile of Atopic Dermatitis Patients

(2010) Junko Ishikawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Total and Low-Density Lipoprotein Cholesterol Levels are Associated with Atopy in Schoolchildren

(2010) Takashi Kusunoki et al.   JOURNAL OF PEDIATRICS

Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

(2010) Chiara De Luca et al.   MEDIATORS OF INFLAMMATION

CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

(2010) Annemieke de Jong et al.   NATURE IMMUNOLOGY

Microbiota restoration: natural and supplemented recovery of human microbial communities

(2010) Gregor Reid et al.   NATURE REVIEWS MICROBIOLOGY

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

(2010) Y. Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice

(2009) Andreas Elentner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Involvement of the BLT2receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice

(2008) H J Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

MafG controls the hypoxic response of cells by accumulating HIF-1α in the nuclei

(2008) Koji Ueda et al.   FEBS LETTERS

Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk

(2008) Stephan Weidinger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Is eczema really on the increase worldwide?

(2007) Hywel Williams et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers

(2007) Karin M. Aberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY