Natural Compounds for Counteracting Nonalcoholic Fatty Liver Disease (NAFLD): Advantages and Limitations of the Suggested Candidates

Verbascoside inhibits the epithelial‐mesenchymal transition of prostate cancer cells through high‐mobility group box 1/receptor for advanced glycation end‐products/ TGF ‐β pathway

(2021) Chun‐Hsien Wu et al.   ENVIRONMENTAL TOXICOLOGY

Caffeic acid prevents non-alcoholic fatty liver disease induced by a high-fat diet through gut microbiota modulation in mice

(2021) Hong-Na Mu et al.   FOOD RESEARCH INTERNATIONAL

Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial

(2021) Asieh Mansour et al.   Nutrition Journal

The Occurrence and Biological Activity of Tormentic Acid—A Review

(2021) Marta Olech et al.   MOLECULES

Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K /Akt/ mTOR and NF‐κB signalling pathways

(2020) Xing Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

Multiple Parallel Hits Hypothesis in NAFLD – Revisited After a Decade

(2020) Herbert Tilg et al.   HEPATOLOGY

Fish oil and chicoric acid combination protects better against palmitate-induced lipid accumulation via regulating AMPK-mediated SREBP-1/FAS and PPARα/UCP2 pathways

(2020) Mohammad Mohammadi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: A meta-analysis of 11 epidemiological studies

(2020) Umar Hayat et al.   Annals of Hepatology

Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation

(2020) Ana Magdalena Velázquez et al.   Nutrients

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

(2020) Carmen Burgos et al.   Antioxidants

Verbascoside Protects Pancreatic β-Cells against ER-Stress

(2020) Alessandra Galli et al.   Biomedicines

Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial

(2019) María Herranz-López et al.   Scientific Reports

Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

(2019) Tingting Yan et al.   Acta Pharmaceutica Sinica B

Non-Alcoholic Fatty Liver Disease in Children and Adolescents: Lifestyle Change - a Systematic Review and Meta-Analysis

(2018) Melina Utz-Melere et al.   Annals of Hepatology

Caffeic acid ameliorates hepatic steatosis and decreased endoplasmic reticulum stress in high-fat diet-induced obese mice by regulating autophagy

(2018) Hong Min Kim et al.   NUTRITION

Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: A clinical review

(2018) Mohammad Bagherniya et al.   PHARMACOLOGICAL RESEARCH

Caffeine-inducible gene switches controlling experimental diabetes

(2018) Daniel Bojar et al.   Nature Communications

Coffee Intake and Liver Steatosis: A Population Study in a Mediterranean Area

(2018) Nicola Veronese et al.   Nutrients

Nonalcoholic Liver Disease in Children and Adolescents

(2018) Sara Kathryn Smith et al.   Clinics in Liver Disease

Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells

(2018) Rui Guo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Selective Synthesis of 3-O-Palmitoyl-Silybin, a New-to-Nature Flavonolignan with Increased Protective Action against Oxidative Damages in Lipophilic Media

(2018) Samantha Drouet et al.   MOLECULES

Nonalcoholic Fatty Liver Disease

(2018) Irene Pierantonelli et al.   TRANSPLANTATION

Caffeine-stimulated muscle IL-6 mediates alleviation of non-alcoholic fatty liver disease

(2018) Chongye Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells

(2017) Laura Vergani et al.   EUROPEAN JOURNAL OF NUTRITION

Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention

(2017) MG Helal et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease: Evidence and plausible mechanisms

(2017) Shira Zelber-Sagi et al.   LIVER INTERNATIONAL

PTP1B inhibitory and cytotoxic activities of triterpenoids from the aerial parts of Agrimonia pilosa

(2017) Bing Tian Zhao et al.   MEDICINAL CHEMISTRY RESEARCH

Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice

(2017) Syunsuke Watanabe et al.   Metabolic Syndrome and Related Disorders

Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency

(2017) Myungsuk Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis

(2017) Hossein Rafiei et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice

(2017) Wen-Ping Jiang et al.   MOLECULES

Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes

(2017) Robin Poole et al.   BMJ-British Medical Journal

Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes

(2017) Robin Poole et al.   BMJ-British Medical Journal

Lifestyle Interventions Including Nutrition, Exercise, and Supplements for Nonalcoholic Fatty Liver Disease in Children

(2016) Jonathan A. Africa et al.   DIGESTIVE DISEASES AND SCIENCES

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Tormentic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NF-κB signaling pathway

(2016) Yu-Lun Wang et al.   Molecular Medicine Reports

EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease

(2016)   Obesity Facts

Coffee, caffeine and non-alcoholic fatty liver disease?

(2016) Oliver John Kennedy et al.   Therapeutic Advances in Gastroenterology

Lifestyle changes for the treatment of nonalcoholic fatty liver disease: a review of observational studies and intervention trials

(2016) Shira Zelber-Sagi et al.   Therapeutic Advances in Gastroenterology

Tormentic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts via inhibition of TLR4-mediated NF-κB and MAPK signalling pathway

(2015) Cong-Xiang Jian et al.   ARCHIVES OF ORAL BIOLOGY

Natural Products on Nonalcoholic Fatty Liver Disease

(2015) Jiao-Ya Xu et al.   CURRENT DRUG TARGETS

The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular)

(2015) Natalia Rosso et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Chicoric Acid on Mast Cell-Mediated Allergic Inflammation in Vitro and in Vivo

(2015) Na Young Lee et al.   JOURNAL OF NATURAL PRODUCTS

Tormentic acid reduces inflammation in BV-2 microglia by activating the liver X receptor alpha

(2015) A. Ma et al.   NEUROSCIENCE

Tormentic acid in foods exerts anti-proliferation efficacy through inducing apoptosis and cell cycle arrest

(2015) Tian-Tian Zhang et al.   Journal of Functional Foods

Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway

(2015) Shi-Jie Zhang et al.   Food & Function

Evaluation of Hepatocyteprotective and Anti-hepatitis B Virus Properties of Cichoric Acid from Cichorium intybus Leaves in Cell Culture

(2014) Hong-Li Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Verbascoside — A review of its occurrence, (bio)synthesis and pharmacological significance

(2014) Kalina Alipieva et al.   BIOTECHNOLOGY ADVANCES

Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat

(2014) Prem Prakash et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study

(2014) Livia Marques Casanova et al.   FITOTERAPIA

Tormentic Acid, a Major Component of Suspension Cells of Eriobotrya japonica, Suppresses High-Fat Diet-Induced Diabetes and Hyperlipidemia by Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation

(2014) Jin-Bin Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Silymarin's Protective Effects and Possible Mechanisms on Alcoholic Fatty Liver for Rats

(2013) Wei Zhang et al.   Biomolecules & Therapeutics

Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver

(2013) Jiayin Yao et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges

(2013) Jia Xiao et al.   Hepatobiliary & Pancreatic Diseases International

Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway

(2013) Yongxiang Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Coffee and non-alcoholic fatty liver disease: Brewing evidence for hepatoprotection?

(2013) Shaohua Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase

(2013) Chung-Chia Liao et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Impact of coffee on liver diseases: a systematic review

(2013) Sammy Saab et al.   LIVER INTERNATIONAL

Cell Suspension Culture of Eriobotrya japonica Regulates the Diabetic and Hyperlipidemic Signs of High-Fat-Fed Mice

(2013) Chun-Ching Shih et al.   MOLECULES

Oral intake of chicoric acid reduces acute alcohol-induced hepatic steatosis in mice

(2013) Marianne Landmann et al.   NUTRITION

Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans

(2013) Audrey Schlernitzauer et al.   PLoS One

α-Glucosidase inhibitory terpenoids from Potentilla fulgens and their quantitative estimation by validated HPLC method

(2013) Deepak Kumar et al.   Journal of Functional Foods

Beneficial effects of silibinin against the progression of metabolic syndrome, increased oxidative stress, and liver steatosis in Psammomys obesus, a relevant animal model of human obesity and diabetes (在一种与人类肥胖以及糖尿病相关的动物模型肥沙鼠中，水飞蓟素具有拮抗代谢综合征进展、拮抗氧化应激增加以及拮

(2013) Saida Bouderba et al.   Journal of Diabetes

Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury

(2013) J Xiao et al.   Nutrition & Diabetes

Chicoric acid: chemistry, distribution, and production

(2013) Jungmin Lee et al.   Frontiers in Chemistry

Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance

(2012) A. Nakamura et al.   DIABETOLOGIA

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

(2012) Carmela Loguercio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: Analysis of isolated hepatic stellate cells

(2012) MINA KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dietary Composition During Weight-Loss Maintenance

(2012) Bruce Ryan Bistrian   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery

(2012) Rodolphe Anty et al.   JOURNAL OF HEPATOLOGY

Coffee Extract Attenuates Changes in Cardiovascular and Hepatic Structure and Function without Decreasing Obesity in High-Carbohydrate, High-Fat Diet-Fed Male Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Milk Thistle and Its Derivative Compounds: A Review of Opportunities for Treatment of Liver Disease

(2012) E.S. Hackett et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults

(2012) Ji Cheol Bae et al.   PLoS One

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis

(2012) Federico Salamone et al.   Translational Research

Caffeine is protective in patients with non-alcoholic fatty liver disease

(2011) A. Birerdinc et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis

(2011) Federico Salamone et al.   DIGESTIVE AND LIVER DISEASE

Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis

(2011) Jeffrey W. Molloy et al.   HEPATOLOGY

Effect of roasting on chlorogenic acids, caffeine and polycyclic aromatic hydrocarbons levels in two Coffea cultivars: Coffea arabica cv. Catuaí Amarelo IAC-62 and Coffea canephora cv. Apoatã IAC-2258

(2011) Silvia A. V. Tfouni et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Silybin and the liver: From basic research to clinical practice

(2011) Carmela Loguercio   WORLD JOURNAL OF GASTROENTEROLOGY

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

(2010) Gagan Deep et al.   CANCER AND METASTASIS REVIEWS

Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis

(2010) Safiyeh Aghazadeh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Milk thistle in liver diseases: past, present, future

(2010) Ludovico Abenavoli et al.   PHYTOTHERAPY RESEARCH

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome

(2009) C. H. KIM et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells

(2009) Marco Trappoliere et al.   JOURNAL OF HEPATOLOGY

Solid State Mechanochemical Activation of Silybum marianum Dry Extract With Betacyclodextrins: Characterization and Bioavailability of the Coground Systems

(2009) D. Voinovich et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells

(2009) Sangmin Kim et al.   PHYTOMEDICINE