Article
Immunology
Zhiyan Zhou, Ranhui Xi, Jiaxin Liu, Xian Peng, Lei Zhao, Xuedong Zhou, Jiyao Li, Xin Zheng, Xin Xu
Summary: The study identified multiple subtypes of taste receptors in human gingival fibroblasts and highlighted TAS2R16's role in inhibiting pro-inflammatory responses by regulating NF-kappa B signaling. This provides a new target and paradigm for the treatment of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Fang He, Xiaoyan Wu, Qingzhuo Zhang, Yikun Li, Yuyi Ye, Pan Li, Shuai Chen, Yuanyi Peng, Rudiger Hardeland, Yaoyao Xia
Summary: Melatonin exhibits antibacterial effects on various pathogenic bacteria in animals and plants, acting through multiple mechanisms such as direct actions at high concentrations, activation of hosts' defense mechanisms, attenuation of inflammation, and modulation of signaling pathways. Its protective functions involve inhibition of reactive oxygen and nitrogen species, detoxification, and protection against mitochondrial damage, suggesting melatonin as a potential effective approach against bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xuefeng Wang, Baifei Hu, Haiming Hu, Shuhan Zhou, Mingzhu Yin, Xue Cheng, Zhigang Zhang, Hongtao Liu
Summary: In this study, tannic acid (TA) was found to effectively inhibit the replication of hepatitis B virus (HBV) by reducing the content of HBV DNA and viral antigens, decreasing the expression of HBV RNA, upregulating the expression of IL-8, TNF-a, IFN-a, and activating the NF-κB and MAPK pathways. Additionally, TA induced autophagy, which accelerated the elimination of HBV components. These findings elucidate the suppressive effect of TA on HBV replication and provide inspiration for its clinical application in HBV treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Chenhua Wang, Ludi Zhang, Zhen Sun, Xiang Yuan, Baihua Wu, Jin Cen, Lei Cui, Kun Zhang, Chun Li, Jingqi Wu, Yajing Shu, Wenbin Sun, Jing Wang, Lijian Hui
Summary: This study found that long-term cultured proliferating human hepatocytes (lc-ProliHH) triggered excessive macrophage activation through inflammatory response, leading to decreased transplantation efficiency. The study proposed two possible solutions, including blocking immune response with dexamethasone or maturing lc-ProliHH into organoids, to improve their transplantation efficacy.
Article
Immunology
Xiaofang Lv, Chun Fan, Zhongxin Jiang, Wenxuan Wang, Xu Qiu, Qiuxia Ji
Summary: Porphyromonas gingivalis-LPS/ATP stimulation significantly increased the expression of NF-kappa B, the NLRP3 inflammasome, GSDMD, and IL-1β at gene and protein levels, as well as membrane damage, caspase-1 activity, and LDH release. However, pretreatment with ISL noticeably suppressed these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yong-Wei Fu, Lu Li, Xiao-Qian Wang, Yi Zhou, Li-Fang Zhu, You-Min Mei, Yan Xu
Summary: CYLD participates in periodontal inflammatory responses by negatively regulating LPS-induced NF-kappa B signalling, as evidenced by reduced CYLD expression in inflamed gingival tissue samples compared to healthy tissue samples and enhanced proinflammatory cytokine mRNA expression in CYLD-knockdown HGFs stimulated with LPS.
Article
Plant Sciences
Zhuangwei Zhang, Shuoqi Jiang, Hengqun Tian, Yu Zeng, Kang He, Lin Lin, Fangmiao Yu
Summary: The study aimed to investigate the anti-inflammatory effects of Nymphaea hybrida ethanol extract and its polar fractions. The results showed that the ethyl acetate fraction of NHE exhibited significant inhibitory effects on inflammation by suppressing the activation of NF-kappa B and MAPK pathways in LPS-induced inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Hyun Ji Eo, Jun Hyuk Jang, Gwang Hun Park
Summary: Berchemia floribunda (BF), a plant from Rhamnaceae, known for its antioxidant and whitening effects, was studied for its anti-inflammatory properties in this research. The leaves extract (BR-L) showed strong anti-inflammatory activity by inhibiting NO production and suppressing pro-inflammatory mediators in LPS-induced cells. BR-L also demonstrated potential in inhibiting NF-kappa B activation and MAPKs phosphorylation. These findings suggest the potential of BR-L as a candidate for new anti-inflammatory drugs against acute and chronic inflammatory disorders.
Article
Cell Biology
Anni Hu, Fan Xiao, Wenjing Wu, Huilin Xu, Jiansheng Su
Summary: This study investigates the effects of lincRNA-EPS on periodontal inflammation mediated by inflammasomes and reveals that lincRNA-EPS can alleviate periodontitis by suppressing the activation of the NF-kappa B signaling pathway through interacting with TDP43.
CELL PROLIFERATION
(2023)
Article
Plant Sciences
Ying Li, Jin-gang Hou, Zhi Liu, Xiao-jie Gong, Jun-nan Hu, Ying-ping Wang, Wen-cong Liu, Xiang-hui Lin, Zi Wang, Wei Li
Summary: In this study, treatment with 20(R)-Rg3 for 8 weeks in T2D mice not only decreased FBG and AGEs levels, but also improved insulin, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF kappa B signal pathways, showing significant ameliorative effects on DN mice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Weibin Ruan, Xinyun Ji, Yating Qin, Xinxin Zhang, Xiaoning Wan, Chuanmeng Zhu, Chao Lv, Chongqing Hu, Juan Zhou, Li Lu, Xiaomei Guo
Summary: This study investigated the protective effects of harmine against sepsis-induced cardiomyopathy (SIC) and its underlying mechanisms. The results showed that harmine inhibited inflammation and apoptosis, alleviated cardiac dysfunction in mice, and suppressed M1 polarization and inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Summary: Inflammaging is a potential risk factor for cardiovascular diseases, leading to the development of thrombosis and atherosclerosis. Ethanol can induce inflammation and senescence, which are both implicated in cardiovascular diseases. In this study, colchicine was used to mitigate the damaging effects of ethanol on endothelial cells. It prevented senescence, reduced oxidative stress, and inhibited the activation of NF-κB and MAPKs in ethanol-treated endothelial cells. Colchicine ameliorated the ethanol-induced molecular events, resulting in attenuated senescence and senescence-associated secretory phenotype in endothelial cells.
Article
Environmental Sciences
Hui Zhao, Lin Fu, Hui-Xian Xiang, Ying Xiang, Meng-Die Li, Bian-Bian Lv, Zhu-Xia Tan, Lan Gao, Cheng Zhang, De-Xiang Xu
Summary: The study found that Benzo[a]pyrene can cause acute lung injury and inflammation, while the antioxidant N-acetylcysteine (NAC) can alleviate the pulmonary inflammatory response induced by Benzo[a]pyrene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Qingyun Xie, Meng Wei, Bo Zhang, Xia Kang, Da Liu, Wei Zheng, Xianming Pan, Yi Quan, Dongfa Liao, Jun Shen
MOLECULAR MEDICINE REPORTS
(2018)
Article
Chemistry, Physical
Hong-ping Zhang, Wei Hu, Aijun Du, Xiong Lu, Ya-ping Zhang, Jian Zhou, Xiaoyan Lin, Youhong Tang
APPLIED SURFACE SCIENCE
(2018)
Article
Chemistry, Physical
Hong-ping Zhang, Aijun Du, Neha S. Gandhi, Yan Jiao, Yaping Zhang, Xiaoyan Lin, Xiong Lu, Youhong Tang
APPLIED SURFACE SCIENCE
(2018)
Article
Engineering, Biomedical
Donglin Gan, Min Liu, Tong Xu, Kefeng Wang, Hui Tan, Xiong Lu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Materials Science, Biomaterials
Bingjun Zhang, Hongyu Li, Lei He, Zhiwei Han, Teng Zhou, Wei Zhi, Xiaobo Lu, Xiong Lu, Jie Weng
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Donglin Gan, Tong Xu, Wensi Xing, Xiang Ge, Liming Fang, Kefeng Wang, Fuzeng Ren, Xiong Lu
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Engineering, Manufacturing
Hong-ping Zhang, Wei Han, Javad Tavakoli, Ya-ping Zhang, Xiaoyan Lin, Xiong Lu, Yong Ma, Youhong Tang
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2019)
Article
Engineering, Biomedical
Qun Wang, Menghao Wang, Pengfei Li, Kefeng Wang, Liming Fang, Fuzeng Ren, Guoming Lu, Xiong Lu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Article
Materials Science, Biomaterials
Jin He, Haixia Ye, Yulei Li, Ju Fang, Qingsong Mei, Xiong Lu, Fuzeng Ren
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Nanoscience & Nanotechnology
Pengfei Tang, Lu Han, Pengfei Li, Zhanrong Jia, Kefeng Wang, Hongping Zhang, Hui Tan, Tailin Guo, Xiong Lu
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Engineering, Biomedical
Ju Fang, Pengfei Li, Xiong Lu, Liming Fang, Xiaoying Lu, Fuzeng Ren
ACTA BIOMATERIALIA
(2019)
Article
Multidisciplinary Sciences
Donglin Gan, Wensi Xing, Lili Jiang, Ju Fang, Cancan Zhao, Fuzeng Ren, Liming Fang, Kefeng Wang, Xiong Lu
NATURE COMMUNICATIONS
(2019)
Article
Materials Science, Biomaterials
Donglin Gan, Tong Xu, Wensi Xing, Menghao Wang, Ju Fang, Kefeng Wang, Xiang Ge, Chun Wai Chan, Fuzeng Ren, Hui Tan, Xiong Lu
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Materials Science, Biomaterials
Pengfei Li, Zhanrong Jia, Qun Wang, Pengfei Tang, Menghao Wang, Kefeng Wang, Ju Fang, Cancan Zhao, Fuzeng Ren, Xiang Ge, Xiong Lu
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Engineering, Biomedical
Mengting Li, Lili Gao, Junhong Chen, Yan Zhang, Jianxin Wang, Xiong Lu, Ke Duan, Jie Weng, Bo Feng
BIOMEDICAL MATERIALS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)