Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis

TGF-β Activity of a Demineralized Bone Matrix

(2021) Layla Panahipour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting cartilage EGFR pathway for osteoarthritis treatment

(2021) Yulong Wei et al.   Science Translational Medicine

Creb5 establishes the competence for Prg4 expression in articular cartilage

(2021) Cheng-Hai Zhang et al.   Communications Biology

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

(2021) Cindy G. Boer et al.   CELL

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis

(2020) Kwang Il Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

(2020) Sharon L. Kolasinski et al.   Arthritis & Rheumatology

The GDF‐5 mutant M1673 exerts robust anabolic and anti‐catabolic effects in chondrocytes

(2020) Tanja Mang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TGFβ activity released from platelet-rich fibrin adsorbs to titanium surface and collagen membranes

(2020) Francesca Di Summa et al.   Scientific Reports

Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis

(2020) Aobo Zhang et al.   Bone & Joint Research

Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice

(2019) Robert Dalton Chavez et al.   PLoS One

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation

(2019) Fumiko Yano et al.   Scientific Reports

DNA hypermethylation of GDF5 in developmental dysplasia of the hip (DDH)

(2019) Taghi Baghdadi et al.   Molecular Genetics & Genomic Medicine

Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration

(2018) Yukino Hatazawa et al.   FASEB JOURNAL

Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5

(2018) Yoshifumi Takahata et al.   FASEB JOURNAL

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury

(2018) Jiun C Chang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

(2018) Tokio Matsuzaki et al.   Science Translational Medicine

Intra-articular therapy with recombinant human GDF5 arrests disease progression and stimulates cartilage repair in the rat medial meniscus transection (MMT) model of osteoarthritis

(2017) W.R. Parrish et al.   OSTEOARTHRITIS AND CARTILAGE

SOX9 protein is stabilized by TGF-β and regulates PAPSS2 mRNA expression in chondrocytes

(2017) R.D. Chavez et al.   OSTEOARTHRITIS AND CARTILAGE

Joint morphogenetic cells in the adult mammalian synovium

(2017) Anke J. Roelofs et al.   Nature Communications

EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation

(2016) Haoruo Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells

(2016) Yulia Shwartz et al.   Cell Reports

Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton

(2016) Hao Chen et al.   PLoS Genetics

Modulation of Superficial Zone Protein/Lubricin/PRG4 by Kartogenin and Transforming Growth Factor-β1 in Surface Zone Chondrocytes in Bovine Articular Cartilage

(2016) Kazumasa Miyatake et al.   Cartilage

Wnt signaling in cartilage development and diseases: lessons from animal studies

(2015) Yu Usami et al.   LABORATORY INVESTIGATION

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis

(2015) S. Thysen et al.   OSTEOARTHRITIS AND CARTILAGE

Articular Cartilage Endurance and Resistance to Osteoarthritic Changes Require Transcription Factor Erg

(2015) Yoichi Ohta et al.   Arthritis & Rheumatology

Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice

(2015) Elena Kozhemyakina et al.   Arthritis & Rheumatology

Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways

(2014) H. Ogawa et al.   GENES & DEVELOPMENT

Effect of Autologous Platelet Rich Fibrin on the Healing of Experimental Articular Cartilage Defects of the Knee in an Animal Model

(2014) Davoud Kazemi et al.   Biomed Research International

Disturbed Cartilage and Joint Homeostasis Resulting From a Loss of Mitogen-Inducible Gene 6 in a Mouse Model of Joint Dysfunction

(2014) Michael A. Pest et al.   Arthritis & Rheumatology

Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2

(2013) Kerstin Kleinschmidt et al.   BIOMATERIALS

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis

(2013) Y. Akasaki et al.   OSTEOARTHRITIS AND CARTILAGE

NFATc1 and NFATc2 repress spontaneous osteoarthritis

(2013) M. B. Greenblatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis

(2013) K. A. Waller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

(2013) M. Z. C. Ruan et al.   Science Translational Medicine

Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy

(2013) Cynthia M. Coleman et al.   STEM CELLS AND DEVELOPMENT

Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo

(2013) John B Shepard et al.   ARTHRITIS RESEARCH & THERAPY

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Overexpression of GDF5 through an Adenovirus Vector Stimulates Osteogenesis of Human Mesenchymal Stem Cells in vitro and in vivo

(2012) Xiangjun Cheng et al.   CELLS TISSUES ORGANS

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

(2011) Meina Wang et al.   Annals of the New York Academy of Sciences

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification

(2011) Xianrong Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells

(2011) Rika Yasuhara et al.   LABORATORY INVESTIGATION

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

(2011) Mary B. Goldring et al.   TRENDS IN MOLECULAR MEDICINE

Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4

(2010) Jeffrey M. Coles et al.   ARTHRITIS AND RHEUMATISM

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes

(2009) Jinxi Wang et al.   JOURNAL OF PATHOLOGY

Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation

(2009) C Thomas G Appleton et al.   LABORATORY INVESTIGATION

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells

(2008) Shunji Itoh et al.   GENES TO CELLS

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of  -catenin signaling causes defects in postnatal cartilage development

(2008) M. Chen et al.   JOURNAL OF CELL SCIENCE

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes

(2008) S.M. Botter et al.   OSTEOARTHRITIS AND CARTILAGE

Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1α, IGF-I, and TGF-β1

(2007) T.A. Schmidt et al.   OSTEOARTHRITIS AND CARTILAGE