Article
Cell Biology
Paula P. Freire, Sarah S. Cury, Leticia O. Lopes, Geysson J. Fernandez, Jianming Liu, Leonardo Nazario de Moraes, Grasieli de Oliveira, Jakeline S. Oliveira, Diogo de Moraes, Otavio Cabral-Marques, Maeli Dal-Pai-Silva, Xiaoyun Hu, Da-Zhi Wang, Robson F. Carvalho
Summary: IL-6 promotes muscle atrophy by regulating a miRNA network in C2C12 myotubes, impacting various biological processes.
Article
Biochemistry & Molecular Biology
Yizhen Huang, Yute Yang, Jianle Wang, Shasha Yao, Teng Yao, Yining Xu, Zizheng Chen, Putao Yuan, Jun Gao, Shuying Shen, Jianjun Ma
Summary: The study found that miR-21-5p regulates osteoclast differentiation by targeting SKP2, and treatment with miR-21-5p can inhibit bone resorption in vivo, suggesting that it may be a new therapeutic target for osteoporosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Viviana Costa, Marcello De Fine, Valeria Carina, Alice Conigliaro, Lavinia Raimondi, Angela De Luca, Daniele Bellavia, Francesca Salamanna, Riccardo Alessandro, Giovanni Pignatti, Milena Fini, Gianluca Giavaresi
Summary: The research focuses on the role of miR-31-5p and miR-33a-5p in osteoarthritis progression, with identification of Specificity proteins (Sp1) as common miRNA targets through bioinformatic analysis. The study evaluates the possible mechanism of how these miRNAs regulate Sp1 to affect CX43 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Pedro M. Rodrigues, Marta B. Afonso, Andre L. Simao, Tawhidul Islam, Maria M. Gaspar, Colm J. O'Rourke, Monika Lewinska, Jesper B. Andersen, Enara Arretxe, Cristina Alonso, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Raul Jimenez-Aguero, Emma Eizaguirre, Luis Bujanda, Maria J. Pareja, Carina Prip-Buus, Jesus M. Banales, Cecilia M. P. Rodrigues, Rui E. Castro
Summary: This study evaluated the role of hsa-miRNA-21-5p in the development of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients. The expression of hsa-miRNA-21-5p was found to increase with NAFLD severity and was associated with hepatic lipotoxicity. Inhibition of hsa-miRNA-21-5p was shown to prevent the progression of NAFLD to NASH and HCC.
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Francesca Beretta, Yu-Fang Huang, Anna Rostedt Punga
Summary: Myasthenia gravis is an autoimmune neuromuscular disease without objective biomarkers for treatment decisions. miR-30e-5p may serve as a predictive biomarker for the disease course in MG.
Article
Cell & Tissue Engineering
Yongsheng Zeng, Chengcheng Du, Pengcheng Xiao, Yiting Lei, Piao Zhao, Zhenglin Zhu, Shengqiang Gao, Bowen Chen, Shengwen Cheng, Wei Huang, Chen Zhao
Summary: The study showed that Sox9-induced miR-322-5p can promote BMP2-induced chondrogenesis by targeting Smad7, which can be utilized for effective tissue engineering of cartilage.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Huijie Gao, Zhaobin He, Chao Gao, Naiqing Liu, Zhaoyang Zhang, Weibo Niu, Jun Niu, Cheng Peng
Summary: This study identified exosome-encapsulated miR-3124-5p as a promoter of the malignant progression of cholangiocarcinoma by targeting GDF11. Exosomal miR-3124-5p and GDF11 could potentially serve as biomarkers or therapeutic targets for cholangiocarcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meng Huang, Yan Wang, Zhenning Wang, Qiaozhen Qin, Heyang Zhang, Shuirong Liu, Jiantong Cui, Yu Zhang, Xiaoxia Jiang, Lulu Xu
Summary: The study shows that miR-134-5p inhibits osteoclast formation through targeting the Itgb1 gene and regulating the MAPK pathway, suggesting it could be a potential target for osteoporosis therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jingjie Luan, Guiyi Che, Gu Man, Feng Xiao
Summary: This study demonstrates that the anti-OA effects of Rb1 relies on the inhibited expression of miR-21-5p, providing valuable information for exploring novel targets for the development of anti-OA strategies.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jian Huang, Yumei Lai, Jun Li, Lan Zhao
Summary: Temporomandibular joint osteoarthritis (TMJ OA) is a common disorder causing pain and dysfunction in the jaw and surrounding tissues. This study found that the loss of microRNAs miR-204 and miR-211 led to an OA-like phenotype in the TMJ, including cartilage degradation and abnormal bone remodeling. The disruption of osteogenesis and chondrogenesis balance in the TMJ may underlie TMJ OA. Additionally, the loss of miR-204/-211 led to abnormal collagen components, cartilage-degrading enzymes, and increased pain.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Haocheng Qin, Cuicui Wang, Yonghua He, Aiwu Lu, Tiandao Li, Bo Zhang, Jie Shen
Summary: Osteoarthritis (OA) is a prevalent joint disease and a leading cause of disability, but its underlying pathogenesis is poorly understood. Inflammation is known to disturb joint homeostasis in OA, and microRNA-146a-5p (miR-146a-5p) has been identified as a key regulator of inflammation in this study. Increased expression of miR-146a-5p was found in human OA cartilage, and experimental results showed that miR-146a-5p can regulate inflammatory responses and catabolism in chondrocytes. Silencing miR-146a-5p alleviated cartilage destruction and reduced OA-induced pain in a mouse model.
Article
Oncology
Rilei Jiang, Xiaolei Chen, Shaohua Ge, Qin Wang, Yichang Liu, Haijun Chen, Jiatuo Xu, Jiang Wu
Summary: The study revealed that miR-21-5p induces pyroptosis in colorectal cancer through TGFBI regulation, providing important mechanistic insights and expanding its potential for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Yat-Yin Law, Wei-Fang Lee, Chin-Jung Hsu, Yen-You Lin, Chun-Hao Tsai, Chien-Chung Huang, Min-Huan Wu, Chih-Hsin Tang, Ju-Fang Liu
Summary: The research on OA and RA revealed that miR-let-7c-5p and miR-149-5p have inhibitory effects on the transcription of proinflammatory cytokines, suggesting that increasing the expression of these two miRNAs is a novel therapeutic strategy for OA and RA.
Review
Dentistry, Oral Surgery & Medicine
Aobo Zhang, Huasong Tang, Shaopeng Liu, Chuan Ma, Shixing Ma, Huaqiang Zhao
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Review
Dentistry, Oral Surgery & Medicine
Shixing Ma, Xiaole Li, Aobo Zhang, Shaopeng Liu, Haoming Zhao, Huaqiang Zhao
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2019)
Article
Multidisciplinary Sciences
Xiang Wei, Hua-Qiang Zhao, Chuan Ma, Ao-Bo Zhang, Hao Feng, Dong Zhang, Chao Liu
Article
Engineering, Biomedical
Xiang Wei, Baoting Fan, Xuzhuo Chen, Yutian Cheng, Aobo Zhang, Shiqi Yu, Shanyong Zhang, Huaqiang Zhao
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Article
Oncology
Chuan Ma, Tingting Shi, Zhuli Qu, Aobo Zhang, Zuping Wu, Huaqiang Zhao, Haoming Zhao, Hongyu Chen
FRONTIERS IN ONCOLOGY
(2020)
Review
Dentistry, Oral Surgery & Medicine
Yutian Cheng, Lingyu Yuan, Li Ma, Fawei Pang, Xinyu Qu, Aobo (Albert) Zhang
Summary: The study aimed to explore the treatment efficacy of botulinum-A (BTX-A) in nocturnal bruxism. The results showed that BTX-A significantly relieved pain and events of bruxism.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Aobo Zhang, Yuping Liu, Xiaoxiao Liu, XinJia Cai, Lisha Sun, Tiejun Li
Summary: This study aimed to evaluate the clinical outcome of socket shield technique (SST) compared to conventional immediate implantation (CII). Ten studies were included in the review, with a total of 388 implants. Results showed that SST group had lower buccal bone resorption, higher soft tissue recession improvement, higher patient satisfaction rate, and slightly higher ISQ compared to the CII group.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Rheumatology
Shixing Ma, Aobo Zhang, Xiaole Li, Shizhou Zhang, Shaopeng Liu, Haoming Zhao, Shichao Wu, Lei Chen, Chuan Ma, Huaqiang Zhao
ARTHRITIS RESEARCH & THERAPY
(2020)