Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 9, Pages 5005
Publisher
MDPI AG
Online
2022-05-01
DOI
10.3390/ijms23095005
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mdm2 and MdmX: Partners in p53 Destruction
- (2021) James J. Manfredi CANCER RESEARCH
- p53 signaling in cancer progression and therapy
- (2021) Hany E. Marei et al. Cancer Cell International
- Is Immune Therapy Plus Chemotherapy More Effective Than Immune Therapy Alone for Unresectable Recurrent Nasopharyngeal Carcinoma?
- (2021) Xin Zhou et al. Frontiers in Immunology
- TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist
- (2021) Cheng Xu et al. Acta Neuropathologica Communications
- Recent Small-Molecule Inhibitors of the p53–MDM2 Protein–Protein Interaction
- (2020) Anastasia Beloglazkina et al. MOLECULES
- AMG-232 sensitizes high MDM2-expressing tumor cells to T-cell-mediated killing
- (2020) Ilyas Sahin et al. Cell Death Discovery
- MDM2 antagonists as a novel treatment option for acute myeloid leukemia: perspectives on the therapeutic potential of idasanutlin (RG7388)
- (2019) Arushi Khurana et al. OncoTargets and Therapy
- DNA damage kinase signaling: checkpoint and repair at 30 years
- (2019) Michael Charles Lanz et al. EMBO JOURNAL
- Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway
- (2018) Ying Lu et al. Cell Death & Disease
- Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells
- (2018) Lukasz Skalniak et al. Cancers
- ATM, radiation, and the risk of second primary breast cancer
- (2017) Jonine L. Bernstein et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer
- (2017) Veronica Tisato et al. Journal of Hematology & Oncology
- Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
- (2017) Minsoo Choi et al. Nature Communications
- Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges
- (2017) Shaomeng Wang et al. Cold Spring Harbor Perspectives in Medicine
- Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”
- (2016) Michael B. Kastan CANCER RESEARCH
- Autophagy and p53
- (2016) Eileen White Cold Spring Harbor Perspectives in Medicine
- The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
- (2016) Jiandong Chen Cold Spring Harbor Perspectives in Medicine
- Recommendations on reporting requirements for flavonoids in research
- (2015) Douglas A Balentine et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2
- (2015) Karim M ElSawy et al. CELL CYCLE
- Transcription factors that interact with p53 and Mdm2
- (2015) Kazushi Inoue et al. INTERNATIONAL JOURNAL OF CANCER
- The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents
- (2015) J. Canon et al. MOLECULAR CANCER THERAPEUTICS
- The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain
- (2015) Oleg Laptenko et al. MOLECULAR CELL
- Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity
- (2015) YEE-LIN VOON et al. ONCOLOGY REPORTS
- Nasopharyngeal carcinoma: A review
- (2015) Fredrik Petersson SEMINARS IN DIAGNOSTIC PATHOLOGY
- Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib
- (2015) Darrell C. Bessette et al. PLoS One
- Recent progress in sodium channel modulators for pain
- (2014) Sharan K. Bagal et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- SAR405838: An Optimized Inhibitor of MDM2-p53 Interaction That Induces Complete and Durable Tumor Regression
- (2014) S. Wang et al. CANCER RESEARCH
- Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones
- (2014) Danielle Jandial et al. CURRENT CANCER DRUG TARGETS
- Identification of antipsychotic drug fluspirilene as a potential p53-MDM2 inhibitor: a combined computational and experimental study
- (2014) Sachin P. Patil et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
- (2014) Daqing Sun et al. JOURNAL OF MEDICINAL CHEMISTRY
- Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
- (2014) Liwei Zhang et al. NATURE GENETICS
- Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
- (2014) Anil M Narasimha et al. eLife
- Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development
- (2013) Qingjie Ding et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
- (2013) Hongmei Luo et al. LUNG CANCER
- Shellfish Toxins Targeting Voltage-Gated Sodium Channels
- (2013) Fan Zhang et al. Marine Drugs
- Chemistry and Biological Activities of Flavonoids: An Overview
- (2013) Shashank Kumar et al. TheScientificWorldJOURNAL
- DNA Damage Sensing by the ATM and ATR Kinases
- (2013) A. Marechal et al. Cold Spring Harbor Perspectives in Biology
- Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
- (2013) Binh Vu et al. ACS Medicinal Chemistry Letters
- MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells
- (2012) B. Wang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- New Insights into the Link Between DNA Damage and Apoptosis
- (2012) Daniela De Zio et al. ANTIOXIDANTS & REDOX SIGNALING
- Various modes of cell death induced by DNA damage
- (2012) O Surova et al. ONCOGENE
- Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2
- (2012) S. M. Vogel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction
- (2011) Karla L. Malloy et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacologic Activation of p53 by Small-Molecule MDM2 Antagonists
- (2011) Hong Shen et al. CURRENT PHARMACEUTICAL DESIGN
- Recent Advances in the Therapeutic Perspectives of Nutlin-3
- (2011) Paola Secchiero et al. CURRENT PHARMACEUTICAL DESIGN
- Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer
- (2011) Eviatar Natan et al. JOURNAL OF MOLECULAR BIOLOGY
- Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells
- (2011) Marc J. Rigatti et al. MOLECULAR CARCINOGENESIS
- The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention
- (2010) Susan K. Peirce et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- p53 binding to the p21 promoter is dependent on the nature of DNA damage
- (2010) Ewelina Bodzak et al. CELL CYCLE
- p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53
- (2010) Stephanie A. Carter et al. CELL CYCLE
- 5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage
- (2010) J. Chen et al. GENES & DEVELOPMENT
- γH2AX: a sensitive molecular marker of DNA damage and repair
- (2010) L-J Mah et al. LEUKEMIA
- The missing Zinc: p53 misfolding and cancer
- (2010) Stewart N. Loh Metallomics
- Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
- (2010) Ornella Cazzalini et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- The relevance of protein-protein interactions for p53 function: the CPE contribution
- (2010) M. R. Fernandez-Fernandez et al. PROTEIN ENGINEERING DESIGN & SELECTION
- The Tumor Suppressor p53: From Structures to Drug Discovery
- (2010) A. C. Joerger et al. Cold Spring Harbor Perspectives in Biology
- Stereochemical studies of hexylitaconic acid, an inhibitor of p53–HDM2 interaction
- (2009) Atsufumi Nakahashi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Tricetin, a Dietary Flavonoid, Inhibits Proliferation of Human Breast Adenocarcinoma MCF-7 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis
- (2009) Ya-Ling Hsu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction
- (2009) Ryan C. Clark et al. NATURAL PRODUCT REPORTS
- Crystal structure of human CDK4 in complex with a D-type cyclin
- (2009) P. J. Day et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
- (2008) Sanjeev Shangary et al. Annual Review of Pharmacology and Toxicology
- Acetylation Is Indispensable for p53 Activation
- (2008) Yi Tang et al. CELL
- Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series
- (2008) Gwénaël Rabut et al. EMBO REPORTS
- p53 Oligomerization Is Essential for Its C-terminal Lysine Acetylation
- (2008) Yoko Itahana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arginine methylation regulates the p53 response
- (2008) Martin Jansson et al. NATURE CELL BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now