ATM, radiation, and the risk of second primary breast cancer

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors

(2016) Kenta Yamamoto et al.   eLife

Loss-of-function variants in ATM confer risk of gastric cancer

(2015) Hannes Helgason et al.   NATURE GENETICS

Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation

(2015) L. Enns et al.   RADIATION PROTECTION DOSIMETRY

Breast-Cancer Risk in Families with Mutations in PALB2

(2014) Antonis C. Antoniou et al.   NEW ENGLAND JOURNAL OF MEDICINE

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Rare germline mutations inPALB2and breast cancer risk: A population-based study

(2012) Marc Tischkowitz et al.   HUMAN MUTATION

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

(2012) Kenta Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Loss of ATM kinase activity leads to embryonic lethality in mice

(2012) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY

Body mass index and risk of second primary breast cancer: The WECARE Study

(2011) Jennifer D. Brooks et al.   BREAST CANCER RESEARCH AND TREATMENT

ATM Mutations in Patients with Hereditary Pancreatic Cancer

(2011) Nicholas J. Roberts et al.   Cancer Discovery

Characterization ofBRCA1andBRCA2deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study

(2010) Åke Borg et al.   HUMAN MUTATION

Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation inBRCA1orBRCA2

(2010) Kathleen E. Malone et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiation Exposure, the ATM Gene, and Contralateral Breast Cancer in the Women's Environmental Cancer and Radiation Epidemiology Study

(2010) Jonine L. Bernstein et al.   JNCI-Journal of the National Cancer Institute

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Alcohol Intake and Cigarette Smoking and Risk of a Contralateral Breast Cancer: The Women's Environmental Cancer and Radiation Epidemiology Study

(2009) J. A. Knight et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor–Positive Invasive Breast Cancer

(2009) Christopher I. Li et al.   JOURNAL OF CLINICAL ONCOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study

(2008) L Mellemkjær et al.   BRITISH JOURNAL OF CANCER

Variants in the ATM Gene Associated with a Reduced Risk of Contralateral Breast Cancer

(2008) P. Concannon et al.   CANCER RESEARCH

Hereditary breast cancer: new genetic developments, new therapeutic avenues

(2008) Philippe M. Campeau et al.   HUMAN GENETICS

Dose to the Contralateral Breast From Radiotherapy and Risk of Second Primary Breast Cancer in the WECARE Study

(2008) Marilyn Stovall et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Variation of Breast Cancer Risk Among BRCA1/2 Carriers

(2008) Colin B. Begg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Roles of Radiotherapy and Chemotherapy in the Development of Contralateral Breast Cancer

(2008) Maartje J. Hooning et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases

(2008) Hirohiko Yajima et al.   JOURNAL OF MOLECULAR BIOLOGY

A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response

(2008) J. J. Seidel et al.   MOLECULAR AND CELLULAR BIOLOGY

Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

(2008) Elijahu Berkovich et al.   Nature Protocols

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Double-Strand Breaks Induced by Very Low X-Ray Doses are Largely due to Bystander Effects

(2008) Mitsuaki Ojima et al.   RADIATION RESEARCH

Effect of Systemic Adjuvant Treatment on Risk for Contralateral Breast Cancer in the Women's Environment, Cancer and Radiation Epidemiology Study

(2007) Lisbeth Bertelsen et al.   JNCI-Journal of the National Cancer Institute