Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

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Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

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Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity

(2011) Michael S. Samuel et al.   PLoS One

Discovery of 3,4-Diaminocyclobut-3-ene-1,2-dione-Based CXCR2 Receptor Antagonists for the Treatment of Inflammatory Disorders

(2010) Michael P. Dwyer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

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Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model

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Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

A Role for CXCR2 in Senescence, but What about in Cancer?

(2009) J. C. Acosta et al.   CANCER RESEARCH

Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model

(2009) A. R. Raimondi et al.   CANCER RESEARCH

ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis

(2009) Kevin M. O'Hayer et al.   CARCINOGENESIS

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

(2009) S. Vetrano et al.   GUT

NSAIDs and colorectal cancer prevention

(2009) Takeo Iwama   JOURNAL OF GASTROENTEROLOGY

The Atypical Chemokine Receptor D6 Contributes to the Development of Experimental Colitis

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Therapeutic Effect of Blocking CXCR2 on Neutrophil Recruitment and Dextran Sodium Sulfate-Induced Colitis

(2009) S. M. Farooq et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

(2008) Y. Sawanobori et al.   BLOOD

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis

(2008) C. Cataisson et al.   CANCER RESEARCH

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

The Carboxyl-terminal PDZ Ligand Motif of Chemokine Receptor CXCR2 Modulates Post-endocytic Sorting and Cellular Chemotaxis

(2008) Paige J. Baugher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of epithelial and neutrophil CXCR2 on innate immunity and resistance to kidney infection

(2008) M. Svensson et al.   KIDNEY INTERNATIONAL

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

(2008) Victoria Marsh et al.   NATURE GENETICS

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

(2008) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer in inflammatory bowel disease

(2008) Jianlin Xie et al.   WORLD JOURNAL OF GASTROENTEROLOGY